IIUM Repository

Dr Deny Susanti Darnis

Academician and Researcher

Chemistry Department

KULLIYYAH OF SCIENCE

Natural Product Chemistry, Spectroscopic techniques, Extraction and Isolation, Bioactivity studies, Formulation

I am actively engaged in research in Natural Product Chemistry with a strong focus on drug discovery and development from natural resources. My research interests include the isolation of bioactive compounds, optimisation of extraction and separation techniques, and the development of natural-based cosmetic formulations. A major component of my work involves the extraction, isolation, and characterisation of phytochemicals from various natural sources, including plants, marine organisms, animals, and actinomycetes. I employ bioassay-guided isolation approaches together with a range of separation techniques, such as liquid-liquid and solid-liquid extraction methods, to identify compounds with potential biological activities. Structural characterisation of isolated compounds is carried out more...

1. Degree in Pharmacy (Universitas Andalas, Indonesia) 2. Master in Science-Chemistry (University Teknologi Malaysia) 3. PhD in Chemistry (University Teknologi Malaysia)

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  1. Ajiboye, Basiru Olaitan and Onikani, Sunday Amos and Ekundayo, Bidemi Emmanuel and Oladele, Itunu Temitope and Lawal, Olaolu Ebenezer and Bello, Taoheed Olawale and Ogedengbe, Oluwatosin Olalekan and Adedeji, Odunayo Selimot and Bakhtiar, M. Taher and Khotib, Junaidi and Darnis, Deny Susanti and Okesola, Marry Abiola and Babatunji Emmanuel, Oyinloye and Vitalini, Sara and Iriti, Marcello (2026) Rebalancing hepatic carbohydrate metabolism: effects of Dalbergiella welwitschii (Baker) Baker f. (Fabaceae) under diabetic conditions. AIMS Molecular Science, 13 (2). pp. 168-179. ISSN 2372-0301
  2. Raman, Narmada and Nordin, Fazlina and Imran, Siti AM and Md Sabri, Budi Aslini and Darnis, Deny Susanti and Ahmad Amin Noordin, Khairul Bariah and Syed Abdul Kadir, Sharifah Zamiah and Ramasamy, Rajesh (2026) Knowledge and attitude of Malaysian university students towards regenerative medicine therapy and their clinical implications: a cross-sectional study. Frontier in Genetic, 17 (NA). pp. 1-18. E-ISSN 1664-8021
  3. Bakhtiar, M. Taher and Mohd Rosdi, Muhammad Imtiaaz Aziman and Mohd Nizam Nur, Muhammad Syahmil Irsyad and Zainuri, Qurratu Ain and Mohd Nor Shokri, Nur Shafira Izzatie and Mohd Pazli, Nureen Hannani and Darnis, Deny Susanti and Zaini, Erizal and Khotib, Junaidi (2026) Emerging the potential of mRNA technology in Covid-19 vaccine manufacturing. In: Springer Handbook of Medical Biotechnology. Springer, Switzerland, pp. 315-332. ISBN 978-3-032-01635-5
  4. Nurizan, Alya Nur Batrisya and Baharom, Aisyah Mahnum and Mohamed Ibrahim, Nur Hasanah and Alias, Atie Adianie and Darnis, Deny Susanti and Haris, Muhammad Salahuddin and Khotib, Junaidi and Bakhtiar, M. Taher (2026) Emerging niosomal formulations for skin-targeted drug delivery: strategies, applications, and limitations. International Journal of Polymeric Materials and Polymeric Biomaterials, 75 (8). pp. 921-933. ISSN 0091-4037 E-ISSN 1563-535X
  5. Bakhtiar, M. Taher and Muhamad Asri, Muhamad Aqil Ikram and Abdul Rahman, Nur Damia and Zamzuri, Nur Eleisha and Muhammad Faizal, Nur Syazwani and Khotib, Junaidi and Darnis, Deny Susanti and Hasdan, Nurul Athirah and Haris, Muhammad Salahuddin and Rakhmawati, Rita (2026) Serum biomarkers as personalised medicine for diagnostic and therapeutic approaches of hepatocellular carcinoma. Journal of the Egyptian National Cancer Institute, 38 (7). pp. 1-11. ISSN 1110-0362 E-ISSN 2589-0409
  6. Zainal Abidin, Nur Hannah and Bakhtiar, M. Taher and Darnis, Deny Susanti and Mohd Jailani, Muhammad Taufiq and Khotib, Junaidi (2025) Synthesis of silver nanoparticles from dicranopteris linearis extract: physicochemical, cytotoxic, and antimicrobial characterization. Journal of King Saud University - Science, 37 (8). pp. 1-6. ISSN 1018-3647 E-ISSN 2213-686X
  7. Bakhtiar, M. Taher and Aminondin, Sofea 'Aisyah and Nasir, Nur Asyilah and Jasmadi, Noor Afiqah and Nizam, Nur Irdeena Nabella and Shahrul, Ilhan Syahmi and Darnis, Deny Susanti and Khotib, Junaidi and Faiyazuddin, Md and Widodo, Riyanto Teguh and Haris, Muhammad Salahuddin (2025) Sickle cell disease: understanding pathophysiology, clinical features and advances in gene therapy approaches. Frontiers in Pharmacology, 16. pp. 1-15. E-ISSN 1663-9812
  8. Zeheri, Ainul Hayati and Bakhtiar, M. Taher and Mohd Jailani, Muhammad Taufiq and Md Jaffri, Juliana and Darnis, Deny Susanti and Khotib, Junaidi (2025) Green synthesis of silver nanoparticles using Aidia densiflora leaf extract: characterisation and bioactivities. Journal of Pharmacy, 5 (2). pp. 256-270. E-ISSN 2773-5664
  9. Rosdi, Rasmaizatul Akma and Darnis, Deny Susanti and Nik Ali, Ni Fakurudin and Sul'ain, Mohd Dasuki and Mohamad Roze, Mohamad Noor and Wan Ishak, Wan Rosli (2023) Evaluation of nutritional and chemical compositions and morphology of horny little devil (Smilax myosotiflora) from different regions in Malaysia. Songklanakarin Journal of Science and Technology, 45 (2). pp. 228-235. ISSN 0125-3395 E-ISSN 2408-1779
  10. Asmani, Ahmad Zafran Amin and Zainuddin, Ahmad Faris Fahmi and Ahmad Azmi Murad, Nadhirah and Mohd Darwis, Nur Hidayati and Suhaimi, Nur Suhaida and Zaini, Erizal and Bakhtiar, M. Taher and Darnis, Deny Susanti and Khotib, Junaidi (2024) Immunogenicity of monoclonal antibody: causes, consequences, and control strategies. Pathology-Research and Practice, 263. pp. 1-11. ISSN 0344-0338 E-ISSN 1618-0631
  11. Ezani, Muhammad Haziq and Darnis, Deny Susanti and Bakhtiar, M. Taher and Abdilah, Syamsudin (2024) Preparation, characterization, and bioactivity evaluation of curcumin-loaded poly (lactic-co-glycolic acid) nanoparticles. Journal of Pharmacy, 4 (2). pp. 165-175. E-ISSN 2773-5664
  12. Mohd Abas, Muhammad Dhiyauddin and Mohd Asri, Muhammad Fareez and Yusafawi, Nur Anis Suffiah and Rosman, Nur Anis Zahra and Baharudin, Nur Arifah Zahidah and Bakhtiar, M Taher and Darnis, Deny Susanti and Khotib, Junaidi (2024) Advancements of gene therapy in cancer treatment: a comprehensive review. Pathology Research and Practice, 261. pp. 1-11. ISSN 0344-0338 E-ISSN 1618-0631
  13. Shukor, Muhammad Idham and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Aminudin, Nurul Iman and Bakhtiar, M. Taher (2024) A comparative study of protein-rich extract using food grade extraction procedure from marine algae, Ulva lactuca (Chlorophyta): screening through a two-level factorial experimental design strategy. In: 4th International Conference on Chemical Processing and Engineering, IC3PE 2022, 27 September 2022, Hybrid, Yogyakarta.
  14. Roshidi, Muhammad Ameerul Haqim and Darnis, Deny Susanti and Lestari, Widya and Haris @ Harith, Muhammad Salahuddin (2024) Optimization of calcium extraction from Stichopus horrens using sulphuric acid. In: 4th International Conference on Chemical Processing and Engineering, IC3PE 2022, 27 September 2022, Hybrid, Yogyakarta.
  15. Kosasih, Kosasih and Darnis, Deny Susanti and Asianski, Immanuel Puji Hosanna and Maryanto, Dede Irving (2024) Formulation and characterization of antioxidant capsules containing cantigi extract-loaded nanoparticles synthesized via nanoprecipitation method. Journal of Natural Product for Degenerative Diseases, 1 (2). pp. 79-85. ISSN 3031-6847
  16. Badrillah, Nadhirah and Darnis, Deny Susanti and Tengku Mohd. Kamil, Tengku Karmila and Swandiny, Greesty Finotory and Widyastuti, Yuli and Zaini, Erizal and Bakhtiar, M. Taher (2024) Silver nanoparticles biogenically synthesised using Maclurodendron porteri extract and their bioactivities. Heliyon, 10 (4). pp. 1-11. E-ISSN 2405-8440
  17. Shukor, Muhammad Idham and Darnis, Deny Susanti and Aminudin, Nurul Iman and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2023) Optimizing the extraction of secondary metabolites from Ulva lactuca using response surface methodology. In: International Conference on Natural Products 2023 (ICNP 2023), Kuala Lumpur. (Unpublished)
  18. Darnis, Deny Susanti and Shukor, Muhammad Idham and Mohammad Nor, Normawaty and Aminudin, Nurul Iman and Taher, Muhammad (2023) Optimization of extraction procedures for nutritional composition from the marine macroalgae Ulva lactuca as a potential cosmetic activity. In: Global Algae Summit 2023, 17 August 2023, Azman Hashim Hall - UTM Kuala Lumpur. (Unpublished)
  19. Rosdi, Rasmaizatul Akma and Sul'ain, Mohd Dasuki and Darnis, Deny Susanti and Baharun, Bibi Nur Bazlini and Ahmad, Nur Fatihah and Wan Ishak, Wan Rosli (2023) Toxicological evaluations of Smilax myosotiflora methanol extract and its effect on testosterone level of male rats in subacute study. FABAD Journal of Pharmaceutical Sciences, 48 (2). pp. 265-278. ISSN 1300-4182 E-ISSN 2651-4648
  20. Mohamad Razif, Mohamad Irfan and Nizar, Nabilah and Zainal Abidin, Nur Hannah and Muhammad Ali, Syasya Nasuha and Wan Zarimi, Wan Nurul Najihah and Khotib, Junaidi and Darnis, Deny Susanti and Mohd Jailani, Muhammad Taufiq and Taher, Muhammad (2023) Emergence of mRNA vaccines in the management of cancer. Expert Review of Vaccine, 22 (1). pp. 629-642. ISSN 1476-0584 E-ISSN 1744-8395

Most Viewed Items

Item titleViews
1Formulation and evaluation of PVA/PEG peel-off mask containing rich fraction of Centella asiatica and Cucumis sativus extract for anti-ageing2012
2Documentation of three sponge species belong to the family of Petrosiidae1794
3Optimisation of vitamin B12 extraction from green edible seaweed (Ulva lactuca) by applying the central composite design1657
4Evaluation of bioactive compounds in different extracts of Linum usitatissimum and their antibacterial properties1591
5Comparison of the essential oil components in fresh peels of lime (citrus aurantifolia) extracted with supercritical fluid extraction and other three traditional extraction methods1579
6Identification and phylogenetic inference in different mollucs nudibranch species via mitochondrial 16S rDNA1554
7Antioxidant and cytotoxic activities of Calophyllum rubiginosum1491
8Antimicrobial activities of marine sponge using bioassay-direct fractionation and contact bioauthography technique1483
9Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.1482
10Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains1479
11Antimicrobial activity and chemical composition of essential oil of Malaysian Etlingera elatior (Jack) R.M. Smith flowers1460
12Effect of thymol and carvacrol, the major components of thymus capitatus on the growth of pseudomonas aeruginosa1451
13Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes1450
14Study of cytotoxic activities of Rubraxanthone1441
15Protein profiles and antimicrobial activity of common Sunda Toad, Duttaphrynus melanostictus paratoid secretions1433
16Malaysian agrofood and waste products: the value1424
17Characteristics of pelargonium radula as a mercury bioindicator for safety assessment of drinking water1423
18In vitro antiurolithiatic effect of selected Prophetic medicines1418
19Functional foods from Quercus infectoria galls and their bioactivities1413
20Antibacterial activity of extracts from Calophyllum canum1405
21Traditional uses, phytochemistry and biological activities of alocasia species: a systematic review1397
22Chemical composition and antibacterial activities of essential oil of Thymus capitatus from Jordan1393
23Polyphenol content and antioxidant capacity in ethanolic exytacts of organic and conventional fruits (Red apple, lady finger banana and papaya)1384
24Effect of Malaysian anti-diabetic plant extracts on adipocyte cells1381
25Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin1377
26Chitin and Chitosan preparation from Malaysian Black Soldier Fly biomass: a preliminary study1376
27In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.1373
28Genus Pterocarpus: a review of ethnopharmacology, phytochemistry, biological activities, and clinical evidence1366
29In vivo toxicity study of aqueous extracts of cymbopogon citratus (Lemongrass)1360
30Synergism between antibiotics and the extract of selected prophetic medicine toward different types of bacteria1357