IIUM Repository

Dr Deny Susanti Darnis

Academician and Researcher

Chemistry Department


Natural Product Chemistry, Spectroscopic techniques, Extraction and Isolation, Bioactivity studies

I am interested in Natural Product Chemistry research that will lead for drug discovery research. My particular focuses are isolation of active compounds from natural resources, optimization of extraction and separation techniques, and cosmetic formulation. A central aim of my work is on isolation (using several extraction methods) and characterization (using (UV, FTIR, 1D and 2D NMR, MS techniques) of phytochemicals from natural resources (including plants, animal, marine sources and actinomycetes) using bioassay guided isolation and several separations (including liquid-liquid and solid-liquid) techniques. Another primary of my work is optimization extraction process to enhance the yield of active compounds (including essential oil and other secondary metabolites) using Response Surface more...

1. Degree in Pharmacy (Universitas Andalas, Indonesia) 2. Master in Science-Chemistry (University Teknologi Malaysia) 3. PhD in Chemistry (University Teknologi Malaysia)

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Latest Additions

  1. Darnis, Deny Susanti and A.L., Mohd Faizol (2020) Antioxidant properties of nerita articulata from Estuarine Mangrove Kuantan, Pahang Malaysia. In: Bioprospects of coastal ecosystem and sustainable resource management. Noor Publishing, Mauritius, pp. 42-51. ISBN 978-620-2-79106-9
  2. Darnis, Deny Susanti and Bakhtiar, M. Taher (2020) Effect ofco-solvent, temperature, pressure on asiaticoside content in Centella Asiatica using supercritical fluid extraction (P-RIGS19-028-0028). Project Report. UNSPECIFIED. (Unpublished)
  3. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Bakhtiar, M. Taher and Mohammad, Nurul Farahain (2020) Effects of co-solvent, temperature and pressure on asiaticoside content in supercritical fluid extraction of Centella Asiatica. In: 3rd International Conference on Chemistry, Chemical Process and Engineering, 30 September 2020, Jogjakarta. (Unpublished)
  4. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Taher, Muhammad and Mohammad, Nurul Farahain (2020) Optimization of supercritical fluid extraction of asiaticoside from Centella Asiatica using Central Composite Design (CCD). Separation Science and Technology. ISSN 0149-6395 E-ISSN 1520-5754 (In Press)
  5. Omar, Nur Izzati and Darnis, Deny Susanti and Bakhtiar, M. Taher (2019) Comparison on the chemical composition and antioxidant properties of essential Oil from fresh, boiled and freeze-dried the rhizomes of Curcuma zedoaria. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19 - 20 Oct 2019, Kuala Lumpur.
  6. Iqbal, Anwar and Shuib, Nur Azfa and Darnis, Deny Susanti and Miskam, Mazidatulakmam Akmam and Abdul Rahman, Nur Ruzaina and Adam, Farook (2018) Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin. Journal of Physical Science, 29 (3). pp. 95-107. ISSN 1675-3402 E-ISSN 2180-4230
  7. Fadzir, Ummu Afifah and Mokhtar@Makhtar, Khairani Idah and Mustafa Al-Ahmad, Basma Ezzat and Darnis, Deny Susanti (2018) Evaluation of bioactive compounds in different extracts of Linum usitatissimum and their antibacterial properties. Makara Journal Health Research, 22 (3). pp. 121-127. ISSN 2356-3664 E-ISSN 2356-3656
  8. Sulaiman, Fatimatul Akmal and Mohamed Iqbal, Mohammad Anwar and Darnis, Deny Susanti and Adam, Farook and Bakhtiar, M. Taher (2018) Functional foods from Quercus infectoria galls and their bioactivities. In: 34th International Conference on Natural Products (ICNP 2018), 19th-21st March 2018, Pulau Pinang. (Unpublished)
  9. Shafawi, Anis Natasha and Bakhtiar, M. Taher and Darnis, Deny Susanti (2018) Formulation and evaluation of PVA/PEG peel-off mask containing rich fraction of Centella asiatica and Cucumis sativus extract for anti-ageing. In: International Conference of Analytical Sciences (SKAM31), 17th-19th August 2018, Kuantan, Pahang. (Unpublished)
  10. Muhd Zin, Nur Huda and Abd Hamid, Shafida and Wan Abdul Khodir, Wan Kartini and Aminudin, Nurul Iman and Danial, Wan Hazman and Bakhtiar, M. Taher and Darnis, Deny Susanti (2018) Comparison of the essential oil components in fresh peels of lime (citrus aurantifolia) extracted with supercritical fluid extraction and other three traditional extraction methods. In: International Conference of Analytical Sciences (SKAM31), 17th-19th August 2018, Kuantan, Pahang.
  11. Althunibat, Osama Yousef and Qaralleh, Haitham and Abboud, Muayad and Khleifat, Khaled and Majali, Ibrahim S. and Darnis, Deny Susanti and Aldal'In, Hammad Khalifeh H. and Yassin Ahmed Al-dalin, Sati (2016) Effect of thymol and carvacrol, the major components of thymus capitatus on the growth of pseudomonas aeruginosa. Journal of Pure and gyApplied Microbiology, 10 (1). pp. 367-374. ISSN 0973-7510 (In Press)
  12. Qaraleh, Haitham and Idid, Syed Zahir and Saad, Shahbudin and Darnis, Deny Susanti and Althunibat, Osama Y. and Majali, Ibrahim (2016) Antimicrobial alkaloids isolated from marine sponges-Minireview. Journal of Basic and Applied Research, 2 (1). pp. 1-7. ISSN 2413-7014
  13. Fadzir, Ummu Afifah and Mokhtar@Makhtar, Khairani Idah and Mustafa Al-Ahmad, Basma Ezzat and Darnis, Deny Susanti (2017) Identification and detection of bioactive compounds in Linum usitatissimum (Flaxseed) and its antibacterial properties against selected oral pathogens. In: 6th International Conference on Advancement in Science and Technology (iCAST 2017), 8th-9th August 2017, Kuantan, Pahang. (Unpublished)
  14. Majid, Noraishah A. and Phang, Ing Chia and Darnis, Deny Susanti (2017) Characteristics of pelargonium radula as a mercury bioindicator for safety assessment of drinking water. Environmental Science and Pollution Research, 24 (29). pp. 22827-22838. ISSN 0944-1344 E-ISSN 1614-7499
  15. Hashim, Nur Athirah and Ahmad, Farediah and Jani, Nor Akmalazura and Darnis, Deny Susanti (2017) In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. Journal of Essential Oil Bearing Plants, 20 (1). pp. 223-232. ISSN 0972-060X E-ISSN 0976-5026
  16. Ahmad Zahari, Muhamad Syafiq and Darnis, Deny Susanti and Hashi, Abdurezak Abdulahi (2017) Ethical dimension of consuming frog components for medical and research purposes. Revelation and Science, 7 (1). pp. 15-20. ISSN 2229-9645 E-ISSN 2229-9947
  17. Alqudah, Ali and Saad, Shahbudin and Darnis, Deny Susanti and Nordin, Noor Faizul Hadry (2016) Fatty acids as biological markers for symbiotic bacteria in Phyllidia varicosa and Phyllidiella pustulosa. Malaysian Applied Biology, 45 (2). pp. 23-28. ISSN 0012-8643
  18. Sulaiman, Fatimatul Akmal and Fuad, Nurfarahin and Rahman, Farawahida and Iqbal, Anwar and Darnis, Deny Susanti (2016) Antioxidant and antimicrobial properties of Tinospora Crispa (Putarwali) stems methanolic extract. Jurnal Teknologi, 78 (11). pp. 35-40. E-ISSN 21803722
  19. Hashim, Nur Athirah and Ahmad, Farediah and Darnis, Deny Susanti (2016) Antioxidant and antityrosinase activities of piper maingayi HK. essential oil. Jurnal Teknologi, 78 (1). pp. 169-174. ISSN 0127-9696 E-ISSN 2180-3722
  20. Shuib , Nur Azfa and Iqbal , Anwar and Sulaiman, Fatimatul Akmal and Razak, Izzatie and Darnis, Deny Susanti (2015) Antioxidant and antibacterial activity of Ruta Anguvstifolia extracts. Jurnal Teknologi, 77 (25). pp. 101-105. ISSN 0127–9696 E-ISSN 2180–3722

Most Viewed Items

Item titleViews
1Antioxidant and cytotoxic activities of Calophyllum rubiginosum1778
2Documentation of three sponge species belong to the family of Petrosiidae1722
3Antibacterial activity of extracts from Calophyllum canum1718
4Effect of Malaysian anti-diabetic plant extracts on adipocyte cells1714
5Natural antioxidant contents in the seeds of four roselle Malaysian varieties and a kenaf: a comparison1713
6Antimicrobial activity and chemical composition of essential oil of Malaysian Etlingera elatior (Jack) R.M. Smith flowers1613
7Chemical composition and antibacterial activities of essential oil of Thymus capitatus from Jordan1604
8Study of cytotoxic activities of Rubraxanthone1570
9Antimicrobial activities of marine sponge using bioassay-direct fractionation and contact bioauthography technique1558
10Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.1467
11Hepatoprotective activity of methanolic extract of bauhinia purpurea leaves against paracetamol-induced hepatic damage in rats1455
12Antibacterial activities of sponge and coral species collected from Malaysia sea water1453
13Bioactivities of a-mangostin from Garcinia malaccensis Hk.f1369
14Isolation of antibacterial compounds from dichloromethane fraction of Malaysian sponges Neopetrosiaexigua1363
15Determination of total phenolic content in Melastoma malabathricum’s white flowers: a comparison of different extraction methods1319
16Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes1313
17Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua1289
18Antimicrobial compounds from Calophyllum canum1269
19Anti-inflammatory action of components from Melastoma malabathricum1251
20Malaysian agrofood and waste products: the value1211
21Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains1097
22Synergism between antibiotics and the extract of selected prophetic medicine toward different types of bacteria1076
23Identification and phylogenetic inference in different mollucs nudibranch species via mitochondrial 16S rDNA1022
24Isolation and anti-proliferative activity of natural products from green seaweed1012
25Identification and detection of bioactive compounds in Linum usitatissimum (Flaxseed) and its antibacterial properties against selected oral pathogens995
26Isolation of secondary metabolites from quercus infectoria galls and their antimicrobial activity951
27Rice husk ash silica as a potential drug carrier909
28In vivo toxicity study of aqueous extracts of cymbopogon citratus (Lemongrass)904
29Polyphenol content and antioxidant capacity in ethanolic exytacts of organic and conventional fruits (Red apple, lady finger banana and papaya)893
30Antioxidant and antibacterial activities of Ruta angustifolia extract 884