IIUM Repository

Dr Deny Susanti Darnis

Academician and Researcher

Chemistry Department

KULLIYYAH OF SCIENCE

Natural Product Chemistry, Spectroscopic techniques, Extraction and Isolation, Bioactivity studies

I am interested in Natural Product Chemistry research that will lead for drug discovery research. My particular focuses are isolation of active compounds from natural resources, optimization of extraction and separation techniques, and cosmetic formulation. A central aim of my work is on isolation (using several extraction methods) and characterization (using (UV, FTIR, 1D and 2D NMR, MS techniques) of phytochemicals from natural resources (including plants, animal, marine sources and actinomycetes) using bioassay guided isolation and several separations (including liquid-liquid and solid-liquid) techniques. Another primary of my work is optimization extraction process to enhance the yield of active compounds (including essential oil and other secondary metabolites) using Response Surface more...

1. Degree in Pharmacy (Universitas Andalas, Indonesia) 2. Master in Science-Chemistry (University Teknologi Malaysia) 3. PhD in Chemistry (University Teknologi Malaysia)

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  1. Rosdi, Rasmaizatul Akma and Darnis, Deny Susanti and Nik Ali, Ni Fakurudin and Sul'ain, Mohd Dasuki and Mohamad Roze, Mohamad Noor and Wan Ishak, Wan Rosli (2023) Evaluation of nutritional and chemical compositions and morphology of horny little devil (Smilax myosotiflora) from different regions in Malaysia. Songklanakarin Journal of Science and Technology, 45 (2). pp. 228-235. ISSN 0125-3395 E-ISSN 2408-1779
  2. Asmani, Ahmad Zafran Amin and Zainuddin, Ahmad Faris Fahmi and Ahmad Azmi Murad, Nadhirah and Mohd Darwis, Nur Hidayati and Suhaimi, Nur Suhaida and Zaini, Erizal and Bakhtiar, M. Taher and Darnis, Deny Susanti and Khotib, Junaidi (2024) Immunogenicity of monoclonal antibody: causes, consequences, and control strategies. Pathology-Research and Practice, 263. pp. 1-11. ISSN 0344-0338 E-ISSN 1618-0631
  3. Ezani, Muhammad Haziq and Darnis, Deny Susanti and Bakhtiar, M. Taher and Abdilah, Syamsudin (2024) Preparation, characterization, and bioactivity evaluation of curcumin-loaded poly (lactic-co-glycolic acid) nanoparticles. Journal of Pharmacy, 4 (2). pp. 165-175. E-ISSN 2773-5664
  4. Mohd Abas, Muhammad Dhiyauddin and Mohd Asri, Muhammad Fareez and Yusafawi, Nur Anis Suffiah and Rosman, Nur Anis Zahra and Baharudin, Nur Arifah Zahidah and Bakhtiar, M Taher and Darnis, Deny Susanti and Khotib, Junaidi (2024) Advancements of gene therapy in cancer treatment: a comprehensive review. Pathology Research and Practice, 261. pp. 1-11. ISSN 0344-0338 E-ISSN 1618-0631
  5. Shukor, Muhammad Idham and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Aminudin, Nurul Iman and Bakhtiar, M. Taher (2024) A comparative study of protein-rich extract using food grade extraction procedure from marine algae, Ulva lactuca (Chlorophyta): screening through a two-level factorial experimental design strategy. In: 4th International Conference on Chemical Processing and Engineering, IC3PE 2022, 27 September 2022, Hybrid, Yogyakarta.
  6. Roshidi, Muhammad Ameerul Haqim and Darnis, Deny Susanti and Lestari, Widya and Haris @ Harith, Muhammad Salahuddin (2024) Optimization of calcium extraction from Stichopus horrens using sulphuric acid. In: 4th International Conference on Chemical Processing and Engineering, IC3PE 2022, 27 September 2022, Hybrid, Yogyakarta.
  7. Kosasih, Kosasih and Darnis, Deny Susanti and Asianski, Immanuel Puji Hosanna and Maryanto, Dede Irving (2024) Formulation and characterization of antioxidant capsules containing cantigi extract-loaded nanoparticles synthesized via nanoprecipitation method. Journal of Natural Product for Degenerative Diseases, 1 (2). pp. 79-85. ISSN 3031-6847
  8. Badrillah, Nadhirah and Darnis, Deny Susanti and Tengku Mohd. Kamil, Tengku Karmila and Swandiny, Greesty Finotory and Widyastuti, Yuli and Zaini, Erizal and Bakhtiar, M. Taher (2024) Silver nanoparticles biogenically synthesised using Maclurodendron porteri extract and their bioactivities. Heliyon, 10 (4). pp. 1-11. E-ISSN 2405-8440
  9. Shukor, Muhammad Idham and Darnis, Deny Susanti and Aminudin, Nurul Iman and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2023) Optimizing the extraction of secondary metabolites from Ulva lactuca using response surface methodology. In: International Conference on Natural Products 2023 (ICNP 2023), Kuala Lumpur. (Unpublished)
  10. Darnis, Deny Susanti and Shukor, Muhammad Idham and Mohammad Nor, Normawaty and Aminudin, Nurul Iman and Taher, Muhammad (2023) Optimization of extraction procedures for nutritional composition from the marine macroalgae Ulva lactuca as a potential cosmetic activity. In: Global Algae Summit 2023, 17 August 2023, Azman Hashim Hall - UTM Kuala Lumpur. (Unpublished)
  11. Rosdi, Rasmaizatul Akma and Sul'ain, Mohd Dasuki and Darnis, Deny Susanti and Baharun, Bibi Nur Bazlini and Ahmad, Nur Fatihah and Wan Ishak, Wan Rosli (2023) Toxicological evaluations of Smilax myosotiflora methanol extract and its effect on testosterone level of male rats in subacute study. FABAD Journal of Pharmaceutical Sciences, 48 (2). pp. 265-278. ISSN 1300-4182 E-ISSN 2651-4648
  12. Mohamad Razif, Mohamad Irfan and Nizar, Nabilah and Zainal Abidin, Nur Hannah and Muhammad Ali, Syasya Nasuha and Wan Zarimi, Wan Nurul Najihah and Khotib, Junaidi and Darnis, Deny Susanti and Mohd Jailani, Muhammad Taufiq and Taher, Muhammad (2023) Emergence of mRNA vaccines in the management of cancer. Expert Review of Vaccine, 22 (1). pp. 629-642. ISSN 1476-0584 E-ISSN 1744-8395
  13. Swandiny, Greesty Finotory and Primahana, Gian and Prastya, Muhammad Eka and Ariani, Novita and Darnis, Deny Susanti and Hanafi, Muhammad and Abdillah, Syamsudin (2023) An ethnopharmacology study of Indonesian medicinal plants in Gunung Sari village as dipeptidyl peptidase-IV inhibitor. Pharmacia, 70 (2). pp. 365-373. ISSN 0428-0296 E-ISSN 2603-557X
  14. Bakhtiar, M. Taher and Darnis, Deny Susanti and Hamzah, Nurasyikin and Aminudin, Nurul Iman and Ismail, Mohamad Wafiuddin and Danial, Wan Hazman and Shafiee, Saiful 'Arifin and MD Ali, Mohd Adli and Ramli, Muhammad Zahir (2023) Relevance of AI in microbased drug delivery system. In: A Handbook of Artificial Intelligence in Drug Delivery. Academic Press, an imprint of Elsevier, Oxford, United Kingdom, pp. 123-143. ISBN 978-0-323-89925-3
  15. Al-Has, Asilah and Mohammad Noor, Normawaty and Muhammad Shaleh, Siti Raehanah and Ayub, Mohd Nor Azman and Darnis, Deny Susanti and Mustakim, Ghaffur Rahim (2023) Paralytic shellfish profiles produced by the toxic dinoflagellate pyrodinium bahamense from Sepanggar Bay, Malaysia. Pertanika Journal of Tropical Agricultural Science, 46 (1). pp. 359-372. ISSN 1511-3701 E-ISSN 2231-8542
  16. Bakhtiar, M. Taher and Darnis, Deny Susanti and Haris @ Harith, Muhammad Salahuddin and Rushdan, Aina Atiqah and Widodo, Riyanto Teguh and Syukri, Yandi and Khotib, Junaidi (2023) PEGylated liposomes enhance the effect of cytotoxic drug: A review. Heliyon, 9 (3). pp. 1-13. ISSN 2405-8440
  17. Onikanni, Sunday Amos and Lawal, Bashir and Fadaka, Adewale Oluwaseun and Bakare, Oluwafemi and Ezekiel, Adewole and Bakhtiar, Muhammad Taher and Khotib, Junaidi and Darnis, Deny Susanti and Oyinloye, Babatunji Emmanuel and Ajiboye, Basiru Olaitan and Ojo, Oluwafemi Adeleke and Sibuyi, Nicole Remaliah Samantha (2023) Computational and preclinical prediction of the antimicrobial properties of an agent isolated from Monodora myristica: a novel DNA gyrase inhibitor. Molecules, 28 (1953). pp. 1-16. ISSN 1420-3049
  18. Rosdi, Rasmaizatul Akma and Sul’ain, Mohd Dasuki and Darnis, Deny Susanti and Wan Ishak, Wan Rosli (2022) Traditional uses, pharmacology, toxicology and chemical constituents of an aphrodisiac plant, Smilax myosotiflora: a systematic review. Hacettepe University Journal of the Faculty of Pharmacy (HUJPHARM), 42 (4). pp. 276-290. ISSN 1300-0608 E-ISSN 2458-8806
  19. Ruslan, Fatin Shazwani and Farhani, Afiqah and Mohamed Mustafa, Qamellia and Darnis, Deny Susanti and Bakhtiar, M. Taher (2022) Screening on the influenced parameters in asiaticoside extraction from Centella asiatica by two-level factorial design. AIP Conference Proceedings, 2645 (1). 030026-1-030026-6. ISSN 0094-243X E-ISSN 1551-7616 (In Press)
  20. Shukor, Muhammad Idham and Darnis, Deny Susanti and Sabarudin, Nur Syazwani and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2022) Effects of solvent extraction and drying methods of Malaysian seaweed, Sargassum polycystum on fucoxanthin content. AIP Proceeding Conference, 2645 (1). 030025-1. ISSN 0094-243X E-ISSN 1551-7616 (In Press)

Most Viewed Items

Item titleViews
1Formulation and evaluation of PVA/PEG peel-off mask containing rich fraction of Centella asiatica and Cucumis sativus extract for anti-ageing1349
2Documentation of three sponge species belong to the family of Petrosiidae1241
3Optimisation of vitamin B12 extraction from green edible seaweed (Ulva lactuca) by applying the central composite design1150
4Identification and phylogenetic inference in different mollucs nudibranch species via mitochondrial 16S rDNA1072
5Antimicrobial activities of marine sponge using bioassay-direct fractionation and contact bioauthography technique1015
6Evaluation of bioactive compounds in different extracts of Linum usitatissimum and their antibacterial properties1002
7Comparison of the essential oil components in fresh peels of lime (citrus aurantifolia) extracted with supercritical fluid extraction and other three traditional extraction methods997
8Antimicrobial activity and chemical composition of essential oil of Malaysian Etlingera elatior (Jack) R.M. Smith flowers977
9Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains977
10Characteristics of pelargonium radula as a mercury bioindicator for safety assessment of drinking water967
11Protein profiles and antimicrobial activity of common Sunda Toad, Duttaphrynus melanostictus paratoid secretions958
12Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes946
13Effect of thymol and carvacrol, the major components of thymus capitatus on the growth of pseudomonas aeruginosa941
14Malaysian agrofood and waste products: the value939
15In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.939
16Synergism between antibiotics and the extract of selected prophetic medicine toward different types of bacteria938
17Chemical composition and antibacterial activities of essential oil of Thymus capitatus from Jordan937
18Study of cytotoxic activities of Rubraxanthone932
19Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.931
20Antibacterial activity of extracts from Calophyllum canum926
21Antioxidant and cytotoxic activities of Calophyllum rubiginosum921
22Effect of Malaysian anti-diabetic plant extracts on adipocyte cells911
23Antibacterial activities of sponge and coral species collected from Malaysia sea water897
24Optimization of supercritical fluid extraction of asiaticoside from Centella Asiatica using Central Composite Design (CCD)896
25Functional foods from Quercus infectoria galls and their bioactivities886
26Fatty acids as biological markers for symbiotic bacteria in Phyllidia varicosa and Phyllidiella pustulosa882
27Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin877
28In vivo toxicity study of aqueous extracts of cymbopogon citratus (Lemongrass)876
29Polyphenol content and antioxidant capacity in ethanolic exytacts of organic and conventional fruits (Red apple, lady finger banana and papaya)873
30Identification and detection of bioactive compounds in Linum usitatissimum (Flaxseed) and its antibacterial properties against selected oral pathogens866