IIUM Repository

Dr Deny Susanti Darnis

Academician and Researcher

Chemistry Department

KULLIYYAH OF SCIENCE

Natural Product Chemistry, Spectroscopic techniques, Extraction and Isolation, Bioactivity studies

I am interested in Natural Product Chemistry research that will lead for drug discovery research. My particular focuses are isolation of active compounds from natural resources, optimization of extraction and separation techniques, and cosmetic formulation. A central aim of my work is on isolation (using several extraction methods) and characterization (using (UV, FTIR, 1D and 2D NMR, MS techniques) of phytochemicals from natural resources (including plants, animal, marine sources and actinomycetes) using bioassay guided isolation and several separations (including liquid-liquid and solid-liquid) techniques. Another primary of my work is optimization extraction process to enhance the yield of active compounds (including essential oil and other secondary metabolites) using Response Surface more...

1. Degree in Pharmacy (Universitas Andalas, Indonesia) 2. Master in Science-Chemistry (University Teknologi Malaysia) 3. PhD in Chemistry (University Teknologi Malaysia)

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  1. Bakhtiar, Muhammad Taher and Mohd Razali, Najah Fatehah and Darnis, Deny Susanti and Rahman, Md. Atiar and Artasasta, Muh Ade and Zakaria, Zainul Amiruddin (2022) Phytochemical constituents and pharmacological activities of Picrasma javanica: Quassinoids interest. Sains Malaysiana, 5 (31). pp. 757-774. ISSN 01266039 E-ISSN 27350118
  2. Darnis, Deny Susanti (2021) Optimisation of vitamin B12 extraction from green edible seaweed, Ulva lactuca using Central Composite Design. In: 3rd International Seminar on Science and Technology, 30th November 2021, Virtual Conference. (Unpublished)
  3. Darnis, Deny Susanti (2021) Marine algae: chemistry and potential. In: 4th International Seminar on Chemistry Education, 15 September 2021, Virtual Conference. (Unpublished)
  4. Shukor, Muhammad Idham and Darnis, Deny Susanti and Sabarudin, Nur Syazwani and Mohammad Noor, Normawaty and Bakhtiar, Muhammad Taher (2021) Effects of solvent extraction and drying methods of Malaysian seaweed, Sargassum polycystum on Fucoxanthin content. In: 4th International Seminar on Chemical Education, 15 September 2021, Virtual Conference. (Unpublished)
  5. Shukor, Muhammad Idham and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Aminudin, Nurul Iman and Bakhtiar, M. Taher (2021) Effects of drying processes on lysine, leucine and glycine content in wild Ulva lactuca for cosmetic purposes. In: 33rd International Conference of Analytical Sciences (SKAM33), 13-15 September 2021, Virtual Conference. (Unpublished)
  6. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Bakhtiar, M. Taher and Mohammad, Nurul Farahain (2020) Optimization of supercritical fluid extraction of asiaticoside from Centella asiatica using Central Composite Design (CCD). Separation Science and Technology, 56 (16). pp. 2766-2774. ISSN 0149-6395 E-ISSN 1520-5754
  7. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Bakhtiar, M. Taher and Aminudin, Nurul Iman (2021) Effect of different extraction methods on vitamin B12 from edible green seaweed, Ulva lactuca by 2-Level Factorial Design. In: 7th International Conference on Advancement in Science & Technology, 24-26 August 2021, Virtual. (Unpublished)
  8. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Mohammad Nor, Normawaty and Bakhtiar, M. Taher and Aminudin, Nurul Iman (2021) Comparison of boiling and orbital shaking extraction of vitamin B12 from Ulva lactuca using 2-Level Factorial Design. In: Asian Symposium on Medicinal Plants and Spices XVII (2021), Virtual Conference.
  9. Arbain, Dayar and Saputri, Gita Ayu and Syahputra, Ghalib Syukrilah and Widiyastuti, Yuli and Darnis, Deny Susanti and Bakhtiar, M. Taher (2021) Genus Pterocarpus: a review of ethnopharmacology, phytochemistry, biological activities, and clinical evidence. Journal of Ethnopharmacology, 278 (114316). ISSN 0378-8741
  10. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Bakhtiar, M. Taher and Aminudin, Nurul Iman (2021) Screening of factors affecting the vitamin B12 extraction from Ulva Lactuca by 2-level factorial design. In: YSN-ASM International Scientific Virtual Conference (ISVC) 2021, 29th March - 1st April 2021, Virtual. (Unpublished)
  11. Darnis, Deny Susanti and A.L., Mohd Faizol (2020) Antioxidant properties of nerita articulata from Estuarine Mangrove Kuantan, Pahang Malaysia. In: Bioprospects of coastal ecosystem and sustainable resource management. Noor Publishing, Mauritius, pp. 42-51. ISBN 978-620-2-79106-9
  12. Darnis, Deny Susanti and Bakhtiar, M. Taher (2020) Effect ofco-solvent, temperature, pressure on asiaticoside content in Centella Asiatica using supercritical fluid extraction (P-RIGS19-028-0028). Project Report. UNSPECIFIED. (Unpublished)
  13. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Bakhtiar, M. Taher and Mohammad, Nurul Farahain (2020) Effects of co-solvent, temperature and pressure on asiaticoside content in supercritical fluid extraction of Centella Asiatica. In: 3rd International Conference on Chemistry, Chemical Process and Engineering, 30 September 2020, Jogjakarta. (Unpublished)
  14. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Taher, Muhammad and Mohammad, Nurul Farahain (2020) Optimization of supercritical fluid extraction of asiaticoside from Centella Asiatica using Central Composite Design (CCD). Separation Science and Technology. ISSN 0149-6395 E-ISSN 1520-5754 (In Press)
  15. Omar, Nur Izzati and Darnis, Deny Susanti and Bakhtiar, M. Taher (2019) Comparison on the chemical composition and antioxidant properties of essential Oil from fresh, boiled and freeze-dried the rhizomes of Curcuma zedoaria. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19 - 20 Oct 2019, Kuala Lumpur.
  16. Iqbal, Anwar and Shuib, Nur Azfa and Darnis, Deny Susanti and Miskam, Mazidatulakmam Akmam and Abdul Rahman, Nur Ruzaina and Adam, Farook (2018) Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin. Journal of Physical Science, 29 (3). pp. 95-107. ISSN 1675-3402 E-ISSN 2180-4230
  17. Fadzir, Ummu Afifah and Mokhtar@Makhtar, Khairani Idah and Mustafa Al-Ahmad, Basma Ezzat and Darnis, Deny Susanti (2018) Evaluation of bioactive compounds in different extracts of Linum usitatissimum and their antibacterial properties. Makara Journal Health Research, 22 (3). pp. 121-127. ISSN 2356-3664 E-ISSN 2356-3656
  18. Sulaiman, Fatimatul Akmal and Mohamed Iqbal, Mohammad Anwar and Darnis, Deny Susanti and Adam, Farook and Bakhtiar, M. Taher (2018) Functional foods from Quercus infectoria galls and their bioactivities. In: 34th International Conference on Natural Products (ICNP 2018), 19th-21st March 2018, Pulau Pinang. (Unpublished)
  19. Shafawi, Anis Natasha and Bakhtiar, M. Taher and Darnis, Deny Susanti (2018) Formulation and evaluation of PVA/PEG peel-off mask containing rich fraction of Centella asiatica and Cucumis sativus extract for anti-ageing. In: International Conference of Analytical Sciences (SKAM31), 17th-19th August 2018, Kuantan, Pahang. (Unpublished)
  20. Muhd Zin, Nur Huda and Abd Hamid, Shafida and Wan Abdul Khodir, Wan Khartini and Aminudin, Nurul Iman and Danial, Wan Hazman and Bakhtiar, M. Taher and Darnis, Deny Susanti (2018) Comparison of the essential oil components in fresh peels of lime (citrus aurantifolia) extracted with supercritical fluid extraction and other three traditional extraction methods. In: International Conference of Analytical Sciences (SKAM31), 17th-19th August 2018, Kuantan, Pahang.

Most Viewed Items

Item titleViews
1Documentation of three sponge species belong to the family of Petrosiidae2137
2Antioxidant and cytotoxic activities of Calophyllum rubiginosum2066
3Effect of Malaysian anti-diabetic plant extracts on adipocyte cells1968
4Natural antioxidant contents in the seeds of four roselle Malaysian varieties and a kenaf: a comparison1955
5Antibacterial activity of extracts from Calophyllum canum1923
6Antimicrobial activity and chemical composition of essential oil of Malaysian Etlingera elatior (Jack) R.M. Smith flowers1869
7Antimicrobial activities of marine sponge using bioassay-direct fractionation and contact bioauthography technique1858
8Chemical composition and antibacterial activities of essential oil of Thymus capitatus from Jordan1833
9Study of cytotoxic activities of Rubraxanthone1822
10Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.1720
11Antibacterial activities of sponge and coral species collected from Malaysia sea water1714
12Hepatoprotective activity of methanolic extract of bauhinia purpurea leaves against paracetamol-induced hepatic damage in rats1666
13Bioactivities of a-mangostin from Garcinia malaccensis Hk.f1592
14Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes1568
15Isolation of antibacterial compounds from dichloromethane fraction of Malaysian sponges Neopetrosiaexigua1566
16Malaysian agrofood and waste products: the value1516
17Determination of total phenolic content in Melastoma malabathricum’s white flowers: a comparison of different extraction methods1510
18Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua1501
19Antimicrobial compounds from Calophyllum canum1500
20Anti-inflammatory action of components from Melastoma malabathricum1488
21Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains1347
22Synergism between antibiotics and the extract of selected prophetic medicine toward different types of bacteria1288
23Identification and phylogenetic inference in different mollucs nudibranch species via mitochondrial 16S rDNA1280
24Formulation and evaluation of PVA/PEG peel-off mask containing rich fraction of Centella asiatica and Cucumis sativus extract for anti-ageing1258
25Isolation and anti-proliferative activity of natural products from green seaweed1226
26Identification and detection of bioactive compounds in Linum usitatissimum (Flaxseed) and its antibacterial properties against selected oral pathogens1206
27Isolation of secondary metabolites from quercus infectoria galls and their antimicrobial activity1174
28Rice husk ash silica as a potential drug carrier1139
29In vivo toxicity study of aqueous extracts of cymbopogon citratus (Lemongrass)1119
30Polyphenol content and antioxidant capacity in ethanolic exytacts of organic and conventional fruits (Red apple, lady finger banana and papaya)1111