IIUM Repository

Dr Deny Susanti Darnis

Academician and Researcher

Chemistry Department

KULLIYYAH OF SCIENCE

Natural Product Chemistry, Spectroscopic techniques, Extraction and Isolation, Bioactivity studies

I am interested in Natural Product Chemistry research that will lead for drug discovery research. My particular focuses are isolation of active compounds from natural resources, optimization of extraction and separation techniques, and cosmetic formulation. A central aim of my work is on isolation (using several extraction methods) and characterization (using (UV, FTIR, 1D and 2D NMR, MS techniques) of phytochemicals from natural resources (including plants, animal, marine sources and actinomycetes) using bioassay guided isolation and several separations (including liquid-liquid and solid-liquid) techniques. Another primary of my work is optimization extraction process to enhance the yield of active compounds (including essential oil and other secondary metabolites) using Response Surface more...

1. Degree in Pharmacy (Universitas Andalas, Indonesia) 2. Master in Science-Chemistry (University Teknologi Malaysia) 3. PhD in Chemistry (University Teknologi Malaysia)

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  1. Al-Has, Asilah and Mohammad Noor, Normawaty and Muhammad Shaleh, Siti Raehanah and Ayub, Mohd Nor Azman and Darnis, Deny Susanti and Mustakim, Ghaffur Rahim (2023) Paralytic shellfish profiles produced by the toxic dinoflagellate pyrodinium bahamense from Sepanggar Bay, Malaysia. Pertanika Journal of Tropical Agricultural Science, 46 (1). pp. 359-372. ISSN 1511-3701 E-ISSN 2231-8542
  2. Bakhtiar, M. Taher and Darnis, Deny Susanti and Haris @ Harith, Muhammad Salahuddin and Rushdan, Aina Atiqah and Widodo, Riyanto Teguh and Syukri, Yandi and Khotib, Junaidi (2023) PEGylated liposomes enhance the effect of cytotoxic drug: A review. Heliyon, 9 (3). pp. 1-13. ISSN 2405-8440 (In Press)
  3. Onikanni, Sunday Amos and Lawal, Bashir and Fadaka, Adewale Oluwaseun and Bakare, Oluwafemi and Ezekiel, Adewole and Bakhtiar, Muhammad Taher and Khotib, Junaidi and Darnis, Deny Susanti and Oyinloye, Babatunji Emmanuel and Ajiboye, Basiru Olaitan and Ojo, Oluwafemi Adeleke and Sibuyi, Nicole Remaliah Samantha (2023) Computational and preclinical prediction of the antimicrobial properties of an agent isolated from Monodora myristica: a novel DNA gyrase inhibitor. Molecules, 28 (1953). pp. 1-16. ISSN 1420-3049
  4. Rosdi, Rasmaizatul Akma and Sul’ain, Mohd Dasuki and Darnis, Deny Susanti and Wan Ishak, Wan Rosli (2022) Traditional uses, pharmacology, toxicology and chemical constituents of an aphrodisiac plant, Smilax myosotiflora: a systematic review. Hacettepe University Journal of the Faculty of Pharmacy (HUJPHARM), 42 (4). pp. 276-290. ISSN 1300-0608 E-ISSN 2458-8806
  5. Ruslan, Fatin Shazwani and Farhani, Afiqah and Mohamed Mustafa, Qamellia and Darnis, Deny Susanti and Bakhtiar, M. Taher (2022) Screening on the influenced parameters in asiaticoside extraction from Centella asiatica by two-level factorial design. AIP Conference Proceedings, 2645 (1). 030026-1-030026-6. ISSN 0094-243X E-ISSN 1551-7616 (In Press)
  6. Shukor, Muhammad Idham and Darnis, Deny Susanti and Sabarudin, Nur Syazwani and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2022) Effects of solvent extraction and drying methods of Malaysian seaweed, Sargassum polycystum on fucoxanthin content. AIP Proceeding Conference, 2645 (1). 030025-1. ISSN 0094-243X E-ISSN 1551-7616 (In Press)
  7. Mohd Hayati, Mohamad Fayyadh and Ab Rahman, Mohd Hafizuddin and Zulkifli, Nur Saadah and Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Mohd Omar, Suhaila (2022) Chitin and Chitosan preparation from Malaysian Black Soldier Fly biomass: a preliminary study. Materials Science Forum, 1069. pp. 201-209. ISSN 1662-9752
  8. Roshidi, Muhammad Ameerul Haqim and Darnis, Deny Susanti and Lestari, Widya and Haris @ Harith, Muhammad Salahuddin (2022) Optimization of calcium extraction from Stichopus Horrens using sulphuric acid. In: 4th International Conference on Chemistry, Chemical Process and Engineering (IC3PE) 2022, 27 September 2022, Jogjakarta, Indoneesia. (Unpublished)
  9. Darnis, Deny Susanti and Mohammad Nor, Normawaty and Bakhtiar, M. Taher and Aminudin, Nurul Iman and Shukor, Muhammad Idham (2022) A comparative study of protein-rich extract using food grade extraction procedure from marine algae, Ulva Lactuca (Chlorophyta): screening through a two-level factorial experimental design strategy. In: 4th International Conference on Chemistry, Chemical Process and Engineering (IC3PE) 2022, 27th September 2022, Jogjakarta, Indonesia. (Unpublished)
  10. Arbain, Dayar and Sriwahyuni, Klaudia and Darnis, Deny Susanti and Bakhtiar, M. Taher (2022) Genus eleutherine: a review of its distribution, traditional uses, phytochemistry, biological activities and their interchange names. South African Journal of Botany, 150. pp. 731-743. ISSN 0254-6299
  11. Darnis, Deny Susanti and Ruslan, Fatin Shazwani and Shukor, Muhammad Idham and Mohammad Noor, Normawaty and Aminudin, Nurul Iman and Bakhtiar, M. Taher and Khotib, Junaidi (2022) Optimisation of Vitamin B12 extraction from green edible seaweed (Ulva lactuca) by applying the central composite design. Molecules, 27 (4495). pp. 1-15. ISSN 1420-3049
  12. Darnis, Deny Susanti and Aminudin, Nurul Iman and Ismail, Mohamad Wafiuddin and Bakhtiar, M. Taher and Shafiee, Saiful 'Arifin and Danial, Wan Hazman and Hamzah, Nurasyikin and UNSPECIFIED (2022) Nanotechnology-based approaches for antitubercular drug delivery. In: Emerging Nanomaterial and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistancece. Elsevier, pp. 365-380.
  13. Darnis, Deny Susanti and Bakhtiar, M. Taher and Haris @ Harith, Muhammad Salahuddin and Khotib, Junaidi (2022) Natural products-based metallic nanoparticles as antimicrobial age. Frontier in Pharmacology, 13 (895616). pp. 1-14. ISSN 1663-9812
  14. Arbain, Dayar and Sinaga, Lorenskia Maria Regina and Bakhtiar, M. Taher and Darnis, Deny Susanti and Zakaria, Zainul Amiruddin and Khotib, Junaidi (2022) Traditional uses, phytochemistry and biological activities of alocasia species: a systematic review. Frontiers: Frontiers in Pharmacology, 13. pp. 1-27. ISSN 1663-9812
  15. Bakhtiar, Muhammad Taher and Mohd Razali, Najah Fatehah and Darnis, Deny Susanti and Rahman, Md. Atiar and Artasasta, Muh Ade and Zakaria, Zainul Amiruddin (2022) Phytochemical constituents and pharmacological activities of Picrasma javanica: Quassinoids interest. Sains Malaysiana, 5 (31). pp. 757-774. ISSN 01266039 E-ISSN 27350118
  16. Darnis, Deny Susanti (2021) Optimisation of vitamin B12 extraction from green edible seaweed, Ulva lactuca using Central Composite Design. In: 3rd International Seminar on Science and Technology, 30th November 2021, Virtual Conference. (Unpublished)
  17. Darnis, Deny Susanti (2021) Marine algae: chemistry and potential. In: 4th International Seminar on Chemistry Education, 15 September 2021, Virtual Conference. (Unpublished)
  18. Shukor, Muhammad Idham and Darnis, Deny Susanti and Sabarudin, Nur Syazwani and Mohammad Noor, Normawaty and Bakhtiar, Muhammad Taher (2021) Effects of solvent extraction and drying methods of Malaysian seaweed, Sargassum polycystum on Fucoxanthin content. In: 4th International Seminar on Chemical Education, 15 September 2021, Virtual Conference. (Unpublished)
  19. Shukor, Muhammad Idham and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Aminudin, Nurul Iman and Bakhtiar, M. Taher (2021) Effects of drying processes on lysine, leucine and glycine content in wild Ulva lactuca for cosmetic purposes. In: 33rd International Conference of Analytical Sciences (SKAM33), 13-15 September 2021, Virtual Conference. (Unpublished)
  20. Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Bakhtiar, M. Taher and Mohammad, Nurul Farahain (2020) Optimization of supercritical fluid extraction of asiaticoside from Centella asiatica using Central Composite Design (CCD). Separation Science and Technology, 56 (16). pp. 2766-2774. ISSN 0149-6395 E-ISSN 1520-5754

Most Viewed Items

Item titleViews
1Documentation of three sponge species belong to the family of Petrosiidae717
2Formulation and evaluation of PVA/PEG peel-off mask containing rich fraction of Centella asiatica and Cucumis sativus extract for anti-ageing679
3Optimisation of Vitamin B12 extraction from green edible seaweed (Ulva lactuca) by applying the central composite design666
4Identification and phylogenetic inference in different mollucs nudibranch species via mitochondrial 16S rDNA488
5Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes479
6Antimicrobial activities of marine sponge using bioassay-direct fractionation and contact bioauthography technique477
7Evaluation of bioactive compounds in different extracts of Linum usitatissimum and their antibacterial properties477
8Antioxidant and cytotoxic activities of Calophyllum rubiginosum469
9Malaysian agrofood and waste products: the value469
10Antimicrobial activity and chemical composition of essential oil of Malaysian Etlingera elatior (Jack) R.M. Smith flowers455
11Study of cytotoxic activities of Rubraxanthone455
12Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.452
13Effect of Malaysian anti-diabetic plant extracts on adipocyte cells446
14Antibacterial activities of sponge and coral species collected from Malaysia sea water443
15Fatty acids as biological markers for symbiotic bacteria in Phyllidia varicosa and Phyllidiella pustulosa437
16Protein profiles and antimicrobial activity of common Sunda Toad, Duttaphrynus melanostictus paratoid secretions436
17Characteristics of pelargonium radula as a mercury bioindicator for safety assessment of drinking water429
18Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin424
19Anti-inflammatory action of components from Melastoma malabathricum423
20Natural antioxidant contents in the seeds of four roselle Malaysian varieties and a kenaf: a comparison423
21Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains421
22Effect of thymol and carvacrol, the major components of thymus capitatus on the growth of pseudomonas aeruginosa417
23Chemical composition and antibacterial activities of essential oil of Thymus capitatus from Jordan409
24Comparison of the essential oil components in fresh peels of lime (citrus aurantifolia) extracted with supercritical fluid extraction and other three traditional extraction methods408
25Optimization of supercritical fluid extraction of asiaticoside from Centella Asiatica using Central Composite Design (CCD)404
26In vivo toxicity study of aqueous extracts of cymbopogon citratus (Lemongrass)399
27Ethical dimension of consuming frog components for medical and research purposes399
28Antimicrobial alkaloids isolated from marine sponges-Minireview396
29Antibacterial activity of extracts from Calophyllum canum391
30In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.391