IIUM Repository

Dr Deny Susanti Darnis

Academician and Researcher

Chemistry Department

KULLIYYAH OF SCIENCE

Natural Product Chemistry, Spectroscopic techniques, Extraction and Isolation, Bioactivity studies

I am interested in Natural Product Chemistry research that will lead for drug discovery research. My particular focuses are isolation of active compounds from natural resources, optimization of extraction and separation techniques, and cosmetic formulation. A central aim of my work is on isolation (using several extraction methods) and characterization (using (UV, FTIR, 1D and 2D NMR, MS techniques) of phytochemicals from natural resources (including plants, animal, marine sources and actinomycetes) using bioassay guided isolation and several separations (including liquid-liquid and solid-liquid) techniques. Another primary of my work is optimization extraction process to enhance the yield of active compounds (including essential oil and other secondary metabolites) using Response Surface more...

1. Degree in Pharmacy (Universitas Andalas, Indonesia) 2. Master in Science-Chemistry (University Teknologi Malaysia) 3. PhD in Chemistry (University Teknologi Malaysia)

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  1. Badrillah, Nadhirah and Darnis, Deny Susanti and Tengku Mohd. Kamil, Tengku Karmila and Swandiny, Greesty Finotory and Widyastuti, Yuli and Zaini, Erizal and Bakhtiar, M. Taher (2024) Silver nanoparticles biogenically synthesised using Maclurodendron porteri extract and their bioactivities. Heliyon, 10 (4). pp. 1-11. E-ISSN 2405-8440
  2. Shukor, Muhammad Idham and Darnis, Deny Susanti and Aminudin, Nurul Iman and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2023) Optimizing the extraction of secondary metabolites from Ulva lactuca using response surface methodology. In: International Conference on Natural Products 2023 (ICNP 2023), Kuala Lumpur. (Unpublished)
  3. Darnis, Deny Susanti and Shukor, Muhammad Idham and Mohammad Nor, Normawaty and Aminudin, Nurul Iman and Taher, Muhammad (2023) Optimization of extraction procedures for nutritional composition from the marine macroalgae Ulva lactuca as a potential cosmetic activity. In: Global Algae Summit 2023, 17 August 2023, Azman Hashim Hall - UTM Kuala Lumpur. (Unpublished)
  4. Rosdi, Rasmaizatul Akma and Sul'ain, Mohd Dasuki and Darnis, Deny Susanti and Baharun, Bibi Nur Bazlini and Ahmad, Nur Fatihah and Wan Ishak, Wan Rosli (2023) Toxicological evaluations of Smilax myosotiflora methanol extract and its effect on testosterone level of male rats in subacute study. FABAD Journal of Pharmaceutical Sciences, 48 (2). pp. 265-278. ISSN 1300-4182 E-ISSN 2651-4648
  5. Mohamad Razif, Mohamad Irfan and Nizar, Nabilah and Zainal Abidin, Nur Hannah and Muhammad Ali, Syasya Nasuha and Wan Zarimi, Wan Nurul Najihah and Khotib, Junaidi and Darnis, Deny Susanti and Mohd Jailani, Muhammad Taufiq and Taher, Muhammad (2023) Emergence of mRNA vaccines in the management of cancer. Expert Review of Vaccine, 22 (1). pp. 629-642. ISSN 1476-0584 E-ISSN 1744-8395
  6. Swandiny, Greesty Finotory and Primahana, Gian and Prastya, Muhammad Eka and Ariani, Novita and Darnis, Deny Susanti and Hanafi, Muhammad and Abdillah, Syamsudin (2023) An ethnopharmacology study of Indonesian medicinal plants in Gunung Sari village as dipeptidyl peptidase-IV inhibitor. Pharmacia, 70 (2). pp. 365-373. ISSN 0428-0296 E-ISSN 2603-557X
  7. Bakhtiar, M. Taher and Darnis, Deny Susanti and Hamzah, Nurasyikin and Aminudin, Nurul Iman and Ismail, Mohamad Wafiuddin and Danial, Wan Hazman and Shafiee, Saiful 'Arifin and MD Ali, Mohd Adli and Ramli, Muhammad Zahir (2023) Relevance of AI in microbased drug delivery system. In: A Handbook of Artificial Intelligence in Drug Delivery. Academic Press, an imprint of Elsevier, Oxford, United Kingdom, pp. 123-143. ISBN 978-0-323-89925-3
  8. Al-Has, Asilah and Mohammad Noor, Normawaty and Muhammad Shaleh, Siti Raehanah and Ayub, Mohd Nor Azman and Darnis, Deny Susanti and Mustakim, Ghaffur Rahim (2023) Paralytic shellfish profiles produced by the toxic dinoflagellate pyrodinium bahamense from Sepanggar Bay, Malaysia. Pertanika Journal of Tropical Agricultural Science, 46 (1). pp. 359-372. ISSN 1511-3701 E-ISSN 2231-8542
  9. Bakhtiar, M. Taher and Darnis, Deny Susanti and Haris @ Harith, Muhammad Salahuddin and Rushdan, Aina Atiqah and Widodo, Riyanto Teguh and Syukri, Yandi and Khotib, Junaidi (2023) PEGylated liposomes enhance the effect of cytotoxic drug: A review. Heliyon, 9 (3). pp. 1-13. ISSN 2405-8440
  10. Onikanni, Sunday Amos and Lawal, Bashir and Fadaka, Adewale Oluwaseun and Bakare, Oluwafemi and Ezekiel, Adewole and Bakhtiar, Muhammad Taher and Khotib, Junaidi and Darnis, Deny Susanti and Oyinloye, Babatunji Emmanuel and Ajiboye, Basiru Olaitan and Ojo, Oluwafemi Adeleke and Sibuyi, Nicole Remaliah Samantha (2023) Computational and preclinical prediction of the antimicrobial properties of an agent isolated from Monodora myristica: a novel DNA gyrase inhibitor. Molecules, 28 (1953). pp. 1-16. ISSN 1420-3049
  11. Rosdi, Rasmaizatul Akma and Sul’ain, Mohd Dasuki and Darnis, Deny Susanti and Wan Ishak, Wan Rosli (2022) Traditional uses, pharmacology, toxicology and chemical constituents of an aphrodisiac plant, Smilax myosotiflora: a systematic review. Hacettepe University Journal of the Faculty of Pharmacy (HUJPHARM), 42 (4). pp. 276-290. ISSN 1300-0608 E-ISSN 2458-8806
  12. Ruslan, Fatin Shazwani and Farhani, Afiqah and Mohamed Mustafa, Qamellia and Darnis, Deny Susanti and Bakhtiar, M. Taher (2022) Screening on the influenced parameters in asiaticoside extraction from Centella asiatica by two-level factorial design. AIP Conference Proceedings, 2645 (1). 030026-1-030026-6. ISSN 0094-243X E-ISSN 1551-7616 (In Press)
  13. Shukor, Muhammad Idham and Darnis, Deny Susanti and Sabarudin, Nur Syazwani and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2022) Effects of solvent extraction and drying methods of Malaysian seaweed, Sargassum polycystum on fucoxanthin content. AIP Proceeding Conference, 2645 (1). 030025-1. ISSN 0094-243X E-ISSN 1551-7616 (In Press)
  14. Mohd Hayati, Mohamad Fayyadh and Ab Rahman, Mohd Hafizuddin and Zulkifli, Nur Saadah and Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Mohd Omar, Suhaila (2022) Chitin and Chitosan preparation from Malaysian Black Soldier Fly biomass: a preliminary study. Materials Science Forum, 1069. pp. 201-209. ISSN 1662-9752
  15. Roshidi, Muhammad Ameerul Haqim and Darnis, Deny Susanti and Lestari, Widya and Haris @ Harith, Muhammad Salahuddin (2022) Optimization of calcium extraction from Stichopus Horrens using sulphuric acid. In: 4th International Conference on Chemistry, Chemical Process and Engineering (IC3PE) 2022, 27 September 2022, Jogjakarta, Indoneesia. (Unpublished)
  16. Darnis, Deny Susanti and Mohammad Nor, Normawaty and Bakhtiar, M. Taher and Aminudin, Nurul Iman and Shukor, Muhammad Idham (2022) A comparative study of protein-rich extract using food grade extraction procedure from marine algae, Ulva Lactuca (Chlorophyta): screening through a two-level factorial experimental design strategy. In: 4th International Conference on Chemistry, Chemical Process and Engineering (IC3PE) 2022, 27th September 2022, Jogjakarta, Indonesia. (Unpublished)
  17. Arbain, Dayar and Sriwahyuni, Klaudia and Darnis, Deny Susanti and Bakhtiar, M. Taher (2022) Genus eleutherine: a review of its distribution, traditional uses, phytochemistry, biological activities and their interchange names. South African Journal of Botany, 150. pp. 731-743. ISSN 0254-6299
  18. Darnis, Deny Susanti and Ruslan, Fatin Shazwani and Shukor, Muhammad Idham and Mohammad Noor, Normawaty and Aminudin, Nurul Iman and Bakhtiar, M. Taher and Khotib, Junaidi (2022) Optimisation of Vitamin B12 extraction from green edible seaweed (Ulva lactuca) by applying the central composite design. Molecules, 27 (4495). pp. 1-15. ISSN 1420-3049
  19. Darnis, Deny Susanti and Aminudin, Nurul Iman and Ismail, Mohamad Wafiuddin and Bakhtiar, M. Taher and Shafiee, Saiful 'Arifin and Danial, Wan Hazman and Hamzah, Nurasyikin and UNSPECIFIED (2022) Nanotechnology-based approaches for antitubercular drug delivery. In: Emerging Nanomaterial and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistancece. Elsevier, pp. 365-380.
  20. Darnis, Deny Susanti and Bakhtiar, M. Taher and Haris @ Harith, Muhammad Salahuddin and Khotib, Junaidi (2022) Natural products-based metallic nanoparticles as antimicrobial age. Frontier in Pharmacology, 13 (895616). pp. 1-14. ISSN 1663-9812

Most Viewed Items

Item titleViews
1Formulation and evaluation of PVA/PEG peel-off mask containing rich fraction of Centella asiatica and Cucumis sativus extract for anti-ageing971
2Documentation of three sponge species belong to the family of Petrosiidae904
3Optimisation of Vitamin B12 extraction from green edible seaweed (Ulva lactuca) by applying the central composite design834
4Identification and phylogenetic inference in different mollucs nudibranch species via mitochondrial 16S rDNA702
5Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes651
6Antimicrobial activities of marine sponge using bioassay-direct fractionation and contact bioauthography technique651
7Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.644
8Malaysian agrofood and waste products: the value643
9Antimicrobial activity and chemical composition of essential oil of Malaysian Etlingera elatior (Jack) R.M. Smith flowers642
10Characteristics of pelargonium radula as a mercury bioindicator for safety assessment of drinking water632
11Evaluation of bioactive compounds in different extracts of Linum usitatissimum and their antibacterial properties630
12Chemical composition and antibacterial activities of essential oil of Thymus capitatus from Jordan628
13Comparison of the essential oil components in fresh peels of lime (citrus aurantifolia) extracted with supercritical fluid extraction and other three traditional extraction methods619
14Effect of Malaysian anti-diabetic plant extracts on adipocyte cells619
15Protein profiles and antimicrobial activity of common Sunda Toad, Duttaphrynus melanostictus paratoid secretions617
16Effect of thymol and carvacrol, the major components of thymus capitatus on the growth of pseudomonas aeruginosa614
17Antioxidant and cytotoxic activities of Calophyllum rubiginosum611
18Antibacterial activity of extracts from Calophyllum canum605
19Study of cytotoxic activities of Rubraxanthone604
20In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC.601
21Synergism between antibiotics and the extract of selected prophetic medicine toward different types of bacteria597
22Antibacterial activities of sponge and coral species collected from Malaysia sea water594
23Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin589
24Fatty acids as biological markers for symbiotic bacteria in Phyllidia varicosa and Phyllidiella pustulosa587
25Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains582
26Optimization of supercritical fluid extraction of asiaticoside from Centella Asiatica using Central Composite Design (CCD)578
27Polyphenol content and antioxidant capacity in ethanolic exytacts of organic and conventional fruits (Red apple, lady finger banana and papaya)578
28Anti-inflammatory action of components from Melastoma malabathricum564
29Ethical dimension of consuming frog components for medical and research purposes556
30In vivo toxicity study of aqueous extracts of cymbopogon citratus (Lemongrass)552