IIUM Repository

Dr Deny Susanti Darnis

Academician and Researcher

Chemistry Department

KULLIYYAH OF SCIENCE

Natural Product Chemistry, Spectroscopic techniques, Extraction and Isolation, Bioactivity studies

I am interested in Natural Product Chemistry research that will lead for drug discovery research. My particular focuses are isolation of active compounds from natural resources, optimization of extraction and separation techniques, and cosmetic formulation. A central aim of my work is on isolation (using several extraction methods) and characterization (using (UV, FTIR, 1D and 2D NMR, MS techniques) of phytochemicals from natural resources (including plants, animal, marine sources and actinomycetes) using bioassay guided isolation and several separations (including liquid-liquid and solid-liquid) techniques. Another primary of my work is optimization extraction process to enhance the yield of active compounds (including essential oil and other secondary metabolites) using Response Surface more...

1. Degree in Pharmacy (Universitas Andalas, Indonesia) 2. Master in Science-Chemistry (University Teknologi Malaysia) 3. PhD in Chemistry (University Teknologi Malaysia)

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Latest Additions

  1. Omar, Nur Izzati and Darnis, Deny Susanti and Bakhtiar, M. Taher (2019) Comparison on the chemical composition and antioxidant properties of essential Oil from fresh, boiled and freeze-dried the rhizomes of Curcuma zedoaria. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019), 19th-20th October 2019, Kuala Lumpur.
  2. Iqbal, Anwar and Shuib, Nur Azfa and Darnis, Deny Susanti and Miskam, Mazidatulakmam Akmam and Abdul Rahman, Nur Ruzaina and Adam, Farook (2018) Synthesis and characterisation of rice husk ash silica drug carrier for α-mangostin. Journal of Physical Science, 29 (3). pp. 95-107. ISSN 1675-3402 E-ISSN 2180-4230
  3. Fadzir, Ummu Afifah and Mokhtar@Makhtar, Khairani Idah and Mustafa Al-Ahmad, Basma Ezzat and Darnis, Deny Susanti (2018) Evaluation of bioactive compounds in different extracts of Linum usitatissimum and their antibacterial properties. Makara Journal Health Research, 22 (3). pp. 121-127. ISSN 2356-3664 E-ISSN 2356-3656
  4. Sulaiman, Fatimatul Akmal and Mohamed Iqbal, Mohammad Anwar and Darnis, Deny Susanti and Adam, Farook and Bakhtiar, M. Taher (2018) Functional foods from Quercus infectoria galls and their bioactivities. In: 34th International Conference on Natural Products (ICNP 2018), 19th-21st March 2018, Pulau Pinang. (Unpublished)
  5. Shafawi, Anis Natasha and Bakhtiar, M. Taher and Darnis, Deny Susanti (2018) Formulation and evaluation of PVA/PEG peel-off mask containing rich fraction of Centella asiatica and Cucumis sativus extract for anti-ageing. In: International Conference of Analytical Sciences (SKAM31), 17th-19th August 2018, Kuantan, Pahang. (Unpublished)
  6. Muhd Zin, Nur Huda and Abd Hamid, Shafida and Wan Abdul Khodir, Wan Kartini and Aminudin, Nurul Iman and Danial, Wan Hazman and Bakhtiar, M. Taher and Darnis, Deny Susanti (2018) Comparison of the essential oil components in fresh peels of lime (citrus aurantifolia) extracted with supercritical fluid extraction and other three traditional extraction methods. In: International Conference of Analytical Sciences (SKAM31), 17th-19th August 2018, Kuantan, Pahang.
  7. Althunibat, Osama Yousef and Qaralleh, Haitham and Abboud, Muayad and Khleifat, Khaled and Majali, Ibrahim S. and Darnis, Deny Susanti and Aldal'In, Hammad Khalifeh H. and Yassin Ahmed Al-dalin, Sati (2016) Effect of thymol and carvacrol, the major components of thymus capitatus on the growth of pseudomonas aeruginosa. Journal of Pure and gyApplied Microbiology, 10 (1). pp. 367-374. ISSN 0973-7510 (In Press)
  8. Qaraleh, Haitham and Idid, Syed Zahir and Saad, Shahbudin and Darnis, Deny Susanti and Althunibat, Osama Y. and Majali, Ibrahim (2016) Antimicrobial alkaloids isolated from marine sponges-Minireview. Journal of Basic and Applied Research, 2 (1). pp. 1-7. ISSN 2413-7014
  9. Fadzir, Ummu Afifah and Mokhtar@Makhtar, Khairani Idah and Mustafa Al-Ahmad, Basma Ezzat and Darnis, Deny Susanti (2017) Identification and detection of bioactive compounds in Linum usitatissimum (Flaxseed) and its antibacterial properties against selected oral pathogens. In: 6th International Conference on Advancement in Science and Technology (iCAST 2017), 8th-9th August 2017, Kuantan, Pahang. (Unpublished)
  10. Majid, Noraishah A. and Phang, Ing Chia and Darnis, Deny Susanti (2017) Characteristics of pelargonium radula as a mercury bioindicator for safety assessment of drinking water. Environmental Science and Pollution Research, 24 (29). pp. 22827-22838. ISSN 0944-1344 E-ISSN 1614-7499
  11. Hashim, Nur Athirah and Ahmad, Farediah and Jani, Nor Akmalazura and Darnis, Deny Susanti (2017) In vitro antioxidant, antityrosinase, antibacterial and cytotoxicity activities of the leaf and stem essential oil from piper magnibaccum C. DC. Journal of Essential Oil Bearing Plants, 20 (1). pp. 223-232. ISSN 0972-060X E-ISSN 0976-5026
  12. Ahmad Zahari, Muhamad Syafiq and Darnis, Deny Susanti and Hashi, Abdurezak Abdulahi (2017) Ethical dimension of consuming frog components for medical and research purposes. Revelation and Science, 7 (1). pp. 15-20. ISSN 2229-9645 E-ISSN 2229-9947
  13. Alqudah, Ali and Saad, Shahbudin and Darnis, Deny Susanti and Nordin, Noor Faizul Hadry (2016) Fatty acids as biological markers for symbiotic bacteria in Phyllidia varicosa and Phyllidiella pustulosa. Malaysian Applied Biology, 45 (2). pp. 23-28. ISSN 0012-8643
  14. Sulaiman, Fatimatul Akmal and Fuad, Nurfarahin and Rahman, Farawahida and Iqbal, Anwar and Darnis, Deny Susanti (2016) Antioxidant and antimicrobial properties of Tinospora Crispa (Putarwali) stems methanolic extract. Jurnal Teknologi, 78 (11). pp. 35-40. E-ISSN 21803722
  15. Hashim, Nur Athirah and Ahmad, Farediah and Darnis, Deny Susanti (2016) Antioxidant and antityrosinase activities of piper maingayi HK. essential oil. Jurnal Teknologi, 78 (1). pp. 169-174. ISSN 0127-9696 E-ISSN 2180-3722
  16. Shuib , Nur Azfa and Iqbal , Anwar and Sulaiman, Fatimatul Akmal and Razak, Izzatie and Darnis, Deny Susanti (2015) Antioxidant and antibacterial activity of Ruta Anguvstifolia extracts. Jurnal Teknologi, 77 (25). pp. 101-105. ISSN 0127–9696 E-ISSN 2180–3722
  17. Ahmad Zahari, Muhammad Syafiq and Darnis, Deny Susanti and Tengku Abdul Hamid, Tengku Haziyamin (2015) Protein profiles and antimicrobial activity of common Sunda Toad, Duttaphrynus melanostictus paratoid secretions. In: 3rd International Conference on Biological, Chemical and Environmental Sciences (BCES-2015), 21st-22nd Sept. 2015, Kuala Lumpur.
  18. Alqudah, Ali and Saad, Shahbudin and Nordin, Noor Faizul Hadry and Darnis, Deny Susanti (2015) Identification and phylogenetic inference in different mollucs nudibranch species via mitochondrial 16S rDNA. Brazilian Journal of Biological Sciences, 2 (4). pp. 295-302. ISSN 2358-2731
  19. Shuib, Nur Azra and Sulaiman, Fatimatul Akmal and Razak , Izzatie and Darnis, Deny Susanti (2015) Antioxidant and antibacterial activities of ruta angustifolia extract. Jurnal Teknologi, 77 (25). pp. 101-105. ISSN 0127–9696 E-ISSN 2180–3722
  20. Sulaiman, Fatimatul Akmal and Fuad, Nurfarahain and Rahman, Farawahida and Iqbal, Anwar and Darnis, Deny Susanti (2015) Antioxidant and antimicrobial properties of Tinospora crispa stems methanolic extract. In: International Conference on Advancement in Science and Technology (iCAST 2015) - ‘Frontiers in Biotechnology’, 10th-12th August 2015, Cherating, Pahang. (Unpublished)

Most Viewed Items

Item titleViews
1Antioxidant and cytotoxic activities of Calophyllum rubiginosum1595
2Effect of Malaysian anti-diabetic plant extracts on adipocyte cells1539
3Antibacterial activity of extracts from Calophyllum canum1528
4Documentation of three sponge species belong to the family of Petrosiidae1505
5Natural antioxidant contents in the seeds of four roselle Malaysian varieties and a kenaf: a comparison1505
6Antimicrobial activity and chemical composition of essential oil of Malaysian Etlingera elatior (Jack) R.M. Smith flowers1440
7Chemical composition and antibacterial activities of essential oil of Thymus capitatus from Jordan1401
8Antimicrobial activities of marine sponge using bioassay-direct fractionation and contact bioauthography technique1387
9Study of cytotoxic activities of Rubraxanthone1376
10Hepatoprotective activity of methanolic extract of bauhinia purpurea leaves against paracetamol-induced hepatic damage in rats1273
11Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.1258
12Antibacterial activities of sponge and coral species collected from Malaysia sea water1254
13Isolation of antibacterial compounds from dichloromethane fraction of Malaysian sponges Neopetrosiaexigua1200
14Bioactivities of a-mangostin from Garcinia malaccensis Hk.f1188
15Determination of total phenolic content in Melastoma malabathricum’s white flowers: a comparison of different extraction methods1146
16Friedelin and lanosterol from Garcinia prainiana stimulated glucose uptake and adipocytes differentiation in 3T3-L1 adipocytes1120
17Antimicrobial compounds from Calophyllum canum1116
18Potential antibacterial compounds from Malaysian Sponges Neopetrosiaexigua1113
19Anti-inflammatory action of components from Melastoma malabathricum1051
20Malaysian agrofood and waste products: the value1034
21Synergism between antibiotics and the extract of selected prophetic medicine toward different types of bacteria917
22Synergistic effects of antibiotics in combination with essential oils against pathogenic bacterial strains891
23Isolation and anti-proliferative activity of natural products from green seaweed862
24Identification and phylogenetic inference in different mollucs nudibranch species via mitochondrial 16S rDNA818
25Identification and detection of bioactive compounds in Linum usitatissimum (Flaxseed) and its antibacterial properties against selected oral pathogens808
26In vivo toxicity study of aqueous extracts of cymbopogon citratus (Lemongrass)755
27Isolation of secondary metabolites from quercus infectoria galls and their antimicrobial activity746
28Polyphenol content and antioxidant capacity in ethanolic exytacts of organic and conventional fruits (Red apple, lady finger banana and papaya)742
29Rice husk ash silica as a potential drug carrier741
30In-vivo toxicity of Prophet's medicinal plant, lawsonia inermis (henna) leaves730