Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.

M. Sirat, Hasnah and Darnis, Deny Susanti and Ahmad, Farediah and Takayama, Hiromitsu and Kitajima, Mariko (2010) Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L. Journal of Natural Medicines, 64 (4). pp. 492-495. ISSN 1340-3443

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Abstract

Successive extraction of the dried leaves of Melastoma malabathricum, followed by purification using repeated chromatographic techniques, yielded six compounds, including two amides, auranamide and patriscabratine, a triterpene, a-amyrin, and three flavonoids, quercitrin, quercetin and kaempferol-3-O-(200,600-di-O-p-trans-coumaroyl)-b-glucoside. Their structures were elucidated by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. These three phenolic constituents were found to be active as free radical scavengers, with quercetin being the strongest radical scavenger, having an IC50 value of 0.69 lM in the UV method. Quercitrin and kaempferol-3-O-(200,600-di-O-ptrans- coumaroyl)-b-glucoside showed moderate radical scavenging, with IC50 values of 74.1 and 108.8 lM,respectively.

Item Type:	Article (Journal)
Additional Information:	5641/1570
Uncontrolled Keywords:	Melastoma malabathricum,Melastomataceae, Amides,triterpene, flavonoids
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biomedical Science
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	05 Sep 2011 12:33
Last Modified:	28 Dec 2011 14:51
URI:	http://irep.iium.edu.my/id/eprint/1570

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