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Emergence of mRNA vaccines in the management of cancer

Mohamad Razif, Mohamad Irfan and Nizar, Nabilah and Zainal Abidin, Nur Hannah and Muhammad Ali, Syasya Nasuha and Wan Zarimi, Wan Nurul Najihah and Khotib, Junaidi and Darnis, Deny Susanti and Mohd Jailani, Muhammad Taufiq and Taher, Muhammad (2023) Emergence of mRNA vaccines in the management of cancer. Expert Review of Vaccine, 22 (1). pp. 629-642. ISSN 1476-0584 E-ISSN 1744-8395

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Abstract

Introduction: mRNA vaccines have been developed as a promising cancer management. It is noted that specification of the antigen sequence of the target antigen is necessary for the design and manufacture of an mRNA vaccine. Areas covered: The steps involved in preparing the mRNA-based cancer vaccines are isolation of the mRNA cancer from the target protein using the nucleic acid RNA-based vaccine, sequence construction to prepare the DNA template, in vitro transcription for protein translation from DNA into mRNA strand, 5’ cap addition and poly(A) tailing to stabilize and protect the mRNA from degradation and purification process to remove contaminants produced during preparation. Expert opinion: Lipid nanoparticles, lipid/protamine/mRNA nanoparticles, and cell-penetrating pep- tides have been used to formulate mRNA vaccine and to ensure vaccine stability and delivery to the target site. Delivery of the vaccine to the target site will trigger adaptive and innate immune responses. Two predominant factors of the development of mRNA-based cancer vaccines are intrinsic influence and external influence. In addition, research relating to the dosage, route of administration, and cancer antigen types have been observed to positively impact the development of mRNA vaccine.

Item Type: Article (Journal)
Uncontrolled Keywords: Cancer; preventive; vaccination; vaccine delivery; vaccine preparation
Subjects: R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science
Kulliyyah of Science > Department of Chemistry
Depositing User: Dr Deny Susanti Darnis
Date Deposited: 13 Jul 2023 15:02
Last Modified: 13 Jul 2023 15:04
URI: http://irep.iium.edu.my/id/eprint/105492

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