IIUM Repository

An ethnopharmacology study of Indonesian medicinal plants in Gunung Sari village as dipeptidyl peptidase-IV inhibitor

Swandiny, Greesty Finotory and Primahana, Gian and Prastya, Muhammad Eka and Ariani, Novita and Darnis, Deny Susanti and Hanafi, Muhammad and Abdillah, Syamsudin (2023) An ethnopharmacology study of Indonesian medicinal plants in Gunung Sari village as dipeptidyl peptidase-IV inhibitor. Pharmacia, 70 (2). pp. 365-373. ISSN 0428-0296 E-ISSN 2603-557X

[img] PDF (Journal) - Published Version
Restricted to Repository staff only

Download (1MB) | Request a copy
PDF (Scopus) - Supplemental Material
Download (583kB) | Preview


During an ethnopharmacology study of traditional antidiabetic treatment in Gunung Sari village, Bogor region, Indonesia, fifteen traditional medicinal plants were selected, collected and prepared as crude extracts. Among fifteen plants, only three plants have previously been screened for dipeptidyl peptidase-IV (DPP-IV) inhibitors. Quantitative phytochemical analysis revealed total phe- nolics content (TPC) ranging from 2.27±0.16 to 5.39±0.05 mg GAE/g extract and total alkaloids content (TAC) from 1.07±0.02 to 4.33±0.07 mg QE/g extract. In-vitro DPP-IV inhibitory activity screening showed that Piper ornatum exhibited the highest inhibition (78.11±1.35 %) and the lowest activity by Syzygium polyanthum (34.30±1.57%) at a concentration of 250 μg/mL, respectively. Anal- ysis of chemical constituents using liquid chromatography-high resolution mass spectrometry (LC-HRMS) indicated at least eleven compounds were present in the crude extract. Among them, several peaks were tentatively assigned as pipcrosides and crocatins, which have previously been isolated from Piper crocatum.

Item Type: Article (Journal)
Uncontrolled Keywords: ethnopharmacology study, dipeptidyl peptidase-IV, Pamijahan, Piper ornatum
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Science
Kulliyyah of Science > Department of Chemistry
Depositing User: Dr Deny Susanti Darnis
Date Deposited: 19 Jun 2023 14:42
Last Modified: 14 Jul 2023 16:33
URI: http://irep.iium.edu.my/id/eprint/105159

Actions (login required)

View Item View Item


Downloads per month over past year