The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients

Ramzi, Muhamad Iyad and Kosnin, Muhammad Hazzim and Faisal, Ghasak Ghazi and Mohd Hafiz, Arzmi and Kusumawardani, Anisa and Sabere, Awis Sukarni Mohmad and Makkey, Essam A and Ibrahim, Omar Emad (2021) The effect of eurycoma longifolia jack (Tongkat Ali) root extract on salivary s. mutans, lactobacillus and candida albicans isolated from high-risk caries adult patients. Pharmacognosy journal, 13 (3). pp. 787-791. ISSN 0975-3575

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Abstract

Introduction: The roots of E. longifolia jack (E.L.) or Tongkat Ali have been used in traditional medicine as well as supplements and food additives. Many chemical compounds have been detected in extracts of its roots which are believed to be responsible for its medicinal properties. In this study, our objectives were to study the effects of EL root extracts on the growth of Streptococcus Mutans, Lactobacillus and Candida Albicans isolated from saliva of adult patients with high caries risk. Materials and Methods: The ethanolic extract of the root of this plant was tested against saliva isolated Streptococcus Mutans, Lactobacillus and Candida Albicans via disc diffusion assay at a concentration of 200mg/mL. The minimum inhibitory concentration was carried out by the standard broth microdilution method. Cell viability of test microorganisms against different concentration of the extract and inhibition zones were calculated. Results: Disk diffusion assay showed positive zones of inhibition for all test microorganisms with S. mutans, Lactobacillus and C. albicans exhibiting zones of inhibition of 8.3 ± 0.7mm, 12.4 ± 2.4mm and 21.4 ± 2.7mm respectively. For minimum inhibitory concentration, the test microorganisms were tested at concentration of 250mg/ mL, 125mg/mL, 62.5mg/mL, 31.3mg/mL and 0mg/mL. The minimum inhibitory concentration showed that MIC of S. mutans was at 62.5mg/mL, Lactobacillus at 125mg/mL and C. albicans at 31.3mg/mL. Lastly, the cell viability results supported the MIC determined prior. Conclusion: Ethanol-based E. longifolia Jack root extract has an antimicrobial effect on the following microorganisms isolated from the saliva of high-risk caries adult patients: S. mutans, Lactobacillus and C. albicans.

Item Type:	Article (Journal)
Additional Information:	6388/90534
Uncontrolled Keywords:	Eurycoma longifolia Jack, Inhibition, Salivary isolate, Antimicrobial effect.
Subjects:	R Medicine > R Medicine (General) R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Dentistry > Department of Restorative Dentistry Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Assoc.Prof Ghasak Ghazi Al-Atrakchi
Date Deposited:	05 Jul 2021 16:53
Last Modified:	08 Jul 2021 16:09
URI:	http://irep.iium.edu.my/id/eprint/90534

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