In vitro anti-cancer activities of luvunga scandens (‘Mengkurat Jakun’) on oral squamous cell carcinoma cells

Ichwan, Solachuddin Jauhari Arief and Yacob, Muhammad ‘Azmi and Mohd Ramlee, Mohamad Arif and Lestari, Widya and Taher, Muhammad (2021) In vitro anti-cancer activities of luvunga scandens (‘Mengkurat Jakun’) on oral squamous cell carcinoma cells. Materials Science Forum, 1025. pp. 191-196. ISSN 0255-5476 E-ISSN 1662-9752

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Abstract

Luvunga scandens (“Mengkurat Jakun”) is one of the medicinal plant that produce triterpenoid compounds. A number of studies have reported that the compounds possess antiproliferative activities against various type of cancer cells. The present study aims for anticancer potential of two triterpenoids derived from L. scandens namely flindissol (compound-1) and 3- oxotirucalla-7,24-dien-21-oic-acid (compound-2) on human oral cancer HSC-3 cells. Cytotoxic activities of the triterpenoids were assessed by MTT assay. Apoptosis activities were determined by flow cytometry and caspase 3/7 assay. The MTT assay showed that compounds-1 and -2 markedly induced cytotoxicity on HSC-3 cells with IC50 10.7 μM and 8.3 μM, respectively. Flow-cytometry analysis demonstrated that both compounds increase the percentage of apoptotic cells by 18.2 % and 16.6 % respectively. Moreover, the caspase 3/7 assay confirmed that compounds-1 and -2 markedly induced caspase 3/7 activities in HSC-3 cells. These results suggest that triterpenoids extracted from L. scandens could be a potential candidate for oral cancer treatment.

Item Type:	Article (Journal)
Additional Information:	5731/90041
Uncontrolled Keywords:	Luvunga scandens, cytotoxicity, apoptosis, oral squamous cell carcinoma
Subjects:	R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Dr. Solachuddin J.A. Ichwan
Date Deposited:	02 Jun 2021 11:01
Last Modified:	02 Jun 2021 11:01
URI:	http://irep.iium.edu.my/id/eprint/90041

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