Lukman Hekiem, Nurul Liyana and Md Ralib, Aliza Aini and Mat Hattar, Maziati Akmal and Ahmad, Farah and Nordin, Anis Nurashikin and Ab Rahim, Rosminazuin and Za’bah, Nor Farahidah (2021) Advanced vapour sensing materials: existing and latent to acoustic wave sensors for VOCs detection as the potential exhaled breath biomarkers for lung cancer. Sensors and Actuators A: Physical, 329 (112792). ISSN 0924-4247 E-ISSN 1873-3069
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Abstract
Lung cancer is the leading cause of death worldwide and has a significant impact on public health across society. Among all types of cancer, lung cancer is typically silent and it is commonly diagnosed at a later stage where treatment is rarely achievable. There is an urgent need for the development of the early diagnosis of lung cancer for an improved survival rate. Preliminary research shows that lung cancer is accompanied by increased oxidative stress which generates volatile organic compounds (VOCs). Hence, breath analysis offers the most promising solution for the early diagnosis of lung cancer as it is non-invasive and radiation free. Potential VOCs biomarkers in exhaled breath associated with oxidative stress and lipid peroxidation have been discussed to provide a quick approach to the diagnosis of lung cancer. Although gas chromatography–mass spectroscopy (GC–MS) able to analyze the VOCs biomarker, it is bulky, high cost, required expertise to handle and consumes a lot of time. Hence, the sensor-based technique provides the solution to overcome the limitation. Recently, acoustic wave sensors such as quartz crystal microbalance (QCM) and surface acoustic wave sensors (SAW) have been used to identify the presence of VOCs in various applications. This is due to its high selectivity, good reproducibility, and fast response sensing materials. The selection of vapour sensing materials plays a crucial role in developing a highly sensitive and selective and fast response acoustic wave sensors. For this purpose, various types of sensing layers from metal oxides, polymers, biopolymers and composites have been studied. We present a critical review of advanced vapour sensing materials that are primarily used in acoustic wave sensors in identifying the presence of various VOCs. Criteria to evaluate the performance of the acoustic wave sensors such as resonance frequency and sensitivity are also discussed.
| Item Type: | Article (Journal) |
|---|---|
| Additional Information: | 7658/89874 |
| Uncontrolled Keywords: | Lung cancer, Breath analysis, Volatile organic compound, Acoustic wave sensor, BiopolymerComposites |
| Subjects: | T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Engineering > Department of Electrical and Computer Engineering Kulliyyah of Engineering > Department of Science |
| Depositing User: | Aliza Aini Md Ralib |
| Date Deposited: | 10 Jun 2021 08:14 |
| Last Modified: | 14 Jul 2021 16:48 |
| URI: | http://irep.iium.edu.my/id/eprint/89874 |
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