Phytochemicals with antifungal properties: Cure from nature

Elgharbawy, Amal A.M. and Samsudin, Nurhusna and Benbelgacem, Farah Fadwa and Hashim, Yumi Zuhanis Has-Yun and Salleh, Hamzah Mohd. and Santhanam, Jacinta (2020) Phytochemicals with antifungal properties: Cure from nature. Malaysian Journal of Microbiology, 16 (4). pp. 323-345. ISSN 1823-8262 E-ISSN 2231-7538

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Abstract

Aims: The exploration of natural products with innovative uses is dynamic and expanding rapidly. Medicinal plants have fascinated many researchers that subsequently lead to research publications highlighting plant extracts with wide range of secondary metabolites such as flavonoids, alkaloids, glycosides, quinones, terpenoids, tannins and saponins that exhibit antimicrobial activities and disease control. The concentration of these bioactive compounds in each plant species varies based on the pathosystem and environmental conditions. This study aims to uncover the various types of phytochemicals with antifungal properties. Methodology and results: Seven categories of plant-based antifungal compounds were reviewed, which are terpenoids, saponins, phenolic compounds, coumarins, alkaloids, essential oils and peptides, with examples and structures of some available compounds. The mechanism of action of each category of phytochemical was discussed. Also, the impact of some compounds was explained and elaborated. Conclusion, significance and impact of study: It is of a great importance to explore natural plant fighters against fungal infection. Those active plant components do not only have antifungal properties, but they also help in the healing process and some even exhibit anticancer activities. The development and knowledge of antifungal activities from plant extracts have the potential for applications in antifungal therapy. Since the exact description of how antifungal compounds function in the human body is still unclear more studies are required to unveil phytochemicals’ properties and to elucidate their effects on living cells.

Item Type:	Article (Journal)
Additional Information:	8637/81995
Uncontrolled Keywords:	Antifungal, phytochemical, secondary metabolite, natural products, minimum inhibitory concentration (MIC)
Subjects:	T Technology > TP Chemical technology > TP248.13 Biotechnology T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	Dr AMAL ELGHARBAWY
Date Deposited:	07 Aug 2020 15:02
Last Modified:	29 Dec 2020 16:23
URI:	http://irep.iium.edu.my/id/eprint/81995

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