Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein

Afriza, Dhona and Ichwan, Solachuddin J. A. and Suriyah, Wastuti Hidayati and Wahyuni, Fatma Suri and ., Yanwirasti and Tejo, Bimo Ario (2018) Prediction on binding affinity of nordentatin and quercetin against anti-apoptotic BCL-2 protein. Journal of International Dental and Medical Research, 11 (3). pp. 1116-1122. E-ISSN 1309-100X

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Abstract

Targeting apoptotic cell-death pathways has been a subject of growing interest in discovery of novel anti-cancer agents. Bcl-2 is a member of Bcl-2 family protein that is crucial for cell survival by supressing apoptosis and its overexpression is frequently detected in many type of cancers. Inactivation of Bcl-2 has been considered as an ideal strategy in anti-cancer therapies. A large number of bioactive compounds derived from natural source including Nordentatin and Quercetin have been reported to possess anticancer activities. Here we report the binding affinities of Nordentatin and Quercetin in silico against anti-apoptotic Bcl-2 protein using molecular docking programs. We demonstrate for the first time that Nordentatin showed optimum binding affinity with Bcl-2, similar to those shown by Quercetin. As the Quercetin has been previously known to play a role in cancer cell apoptosis through down-regulation of Bcl-2, the result indicated that Nordentatin could also be proposed as a prospective anticancer molecule via inhibition of Bcl-2 protein.

Item Type:	Article (Journal)
Additional Information:	5731/69230
Uncontrolled Keywords:	Bcl-2 Nordentatin, Quercetin, Binding affinity, Docking
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Dentistry
Depositing User:	Dr. Solachuddin J.A. Ichwan
Date Deposited:	16 Jan 2019 16:18
Last Modified:	16 Jan 2019 16:18
URI:	http://irep.iium.edu.my/id/eprint/69230

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