Anticancer activity of acetogenins from Annona muricata fruit

Daddiouaissa, Djabir and Amid, Azura (2018) Anticancer activity of acetogenins from Annona muricata fruit. International Medical Journal Malaysia, 17 (3). pp. 103-112. ISSN 1823-4631 E-ISSN 1823-4631

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Abstract

Medicinal plants become very important in our days for their therapeutic benefits to humankind. It sustains human health, and it is commonly known as herbal medicines since ancient times. Annona muricata is a heart-shaped fruit that is consumed raw or as the fruit juice in the tropical area. A. muricata is used in traditional and alternative medicine to treat different ailments such as diabetes, hypertension, respiratory and skin illness, inflammation and cancer. A. muricata contains essential anticancer agents named acetogenins that play the significant role in various cancer types. Acetogenins are strong nicotinamide adenine dinucleotide oxidase inhibitors of the cancer cell's mitochondrial membrane but showed neurotoxic effects in rats. Therefore, acetogenins need to be further investigated to determine the exact mechanisms of action, long-term safety, optimal dosage, and potential side effects. Given the extensive studies on A. muricata, this review focuses on the phytochemistry, medicinal uses, biological activities and the mechanisms of action for the fruit extracts and acetogenins, to stimulate further studies on the fruit pulp used for human consumption.

Item Type:	Article (Journal)
Additional Information:	3688
Uncontrolled Keywords:	Acetogenins, Anticancer, Annona muricata, complex I mitochondrial
Subjects:	T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	Prof Ts Dr Azura Amid
Date Deposited:	16 Dec 2018 22:56
Last Modified:	27 Jan 2019 15:13
URI:	http://irep.iium.edu.my/id/eprint/68372

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