Enhanced antioxidant gel formulation with papaya Leaf extract and virgin Coconut oil: optimization approach

Sukamdi, Dyani Primasari and ,, Sophia Farra Ileina and ,, Rima Erviana and ,, Vella Lailli Damarwati and ,, Sabtanti Harimurti and Amid, Azura (2026) Enhanced antioxidant gel formulation with papaya Leaf extract and virgin Coconut oil: optimization approach. Borneo Journal of Pharmacy, 9 (2). pp. 179-187. E-ISSN 2621-4814

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Abstract

Redness, pigmentation, premature aging, xerosis, and even the risk of cancer can result from excessive exposure to free radicals in the form of ultraviolet (UV) radiation, which can cause skin damage. Antioxidants, including β-carotene, α-tocopherol, ascorbic acid, and flavonoids, are present in papaya (Carica papaya) leaves and Virgin Coconut Oil (VCO). Therefore, these two components may mitigate skin imperfections caused by premature aging. This study aims to formulate and determine the antioxidant activity contained in C. papayaleaf extract gel and VCO. A laboratory-based experimental approach was implemented in this study. Using the infusion method, C. papayaleaves were extracted for 15 minutes to initiate the gel formation. The C. papayaleaf extract gel with VCO was divided into five formulations, with varyingamounts of each ingredient. Organoleptic, homogeneity, viscosity, pH, spreadability, and antioxidant activity tests, conducted using the DPPH method, are included in the preparation testing process. The antioxidant activity test of C. papayaleaf extract gel with VCO in each formula yielded values of 91.32 ppm, 121.21 ppm, 80.19 ppm, 67.04 ppm, and 55.31 ppm, respectively. The results indicated that the quality of the gel preparation and the IC50value of the C. papayaleaf extract gel were influenced by variations in VCO concentration.

Item Type:	Article (Journal)
Additional Information:	3688/130926
Uncontrolled Keywords:	Antioxidant; Gel; Papaya leaf extract; Virgin Coconut Oil
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Science
Depositing User:	Prof Ts Dr Azura Amid
Date Deposited:	20 Sep 2026 22:44
Last Update:	20 Sep 2026 22:44
Queue Number:	2026-09-Q5270
URI:	http://irep.iium.edu.my/id/eprint/130926
Indexed In:	SCOPUS

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