Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel

Al-Bayati, Maryam Riyadh Yaseen and Faisal, Ghasak Ghazi and Abd. Fuaat, Azliana and Ahmad Affandi, Khairunisa and Alallam, Batoul (2023) Improved quality of healed wounds with topical application of Eurycoma Longifolia Jack root extract hydrogel. IIUM Medical Journal Malaysia, 22 (4). pp. 115-121. ISSN 1823-4631 E-ISSN 2735-2285

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Abstract

INTRODUCTION:Collagen is the key component of the extracellular matrix that plays a critical role in the strength and quality of the healed wound. Eurycoma longifoliaJack root extract (TA) has been documented as an anti-inflammatory, antioxidant, and antimicrobial agent that may improve the quality of healed wounds. The objective of this study is to investigate the effect of topical application of TA hydrogel on the quality of the healed skin in rats. MATERIALS AND METHODS: Twenty male Sprague Dawley rats were grouped into 4 groups: Negative control, Hydrocyn®aqua gel positive control, vehicle (Xanthan) hydrogel, and Eurycoma longifolia Jack (TA) hydrogel. Treatments were applied twice daily starting on wounding day until day 21. An excisional wound was created on the back of 20 rats. Tissue samples of the healed skin were collected for histological examination by measuring the epidermal and dermal thicknesses and evaluating the collagen fibre quality by VVG stain. RESULTS:The TA hydrogel grouphad the thickest newly formed epidermis compared with the other experimental groups. For the dermal thickness, compared with the vehicle (xanthan) hydrogel group, TA hydrogel, and Hydrocyn aqua® gel positive control groups showed significantly increased thickness withpvalues 0.020 and 0.045, respectively. Histologically TA hydrogel group showed a significant increase in mixed-oriented collagen fibres, and fascicular collagen bundles and showed profound collagen density. CONCLUSION: TA hydrogel improved the quality of healed skin by increasing the epidermal/dermal thicknesses and enhancing the quality of newly produced collagen fibres. It can be considered a promising and effective wound-healing agent

Item Type:	Article (Journal)
Uncontrolled Keywords:	Wound Healing, Eurycoma longifolia jack, collagen, dermal/epidermal thickness
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Assoc.Prof Ghasak Ghazi Al-Atrakchi
Date Deposited:	24 Oct 2023 12:08
Last Modified:	26 Dec 2023 15:25
URI:	http://irep.iium.edu.my/id/eprint/107625

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