The prevalence of non-albicans candida in oral squamous cell carcinoma: a review

Norazmi, Aini Rasidda and Rismayuddin, Nurul Alia Risma and Tapa, Nor Farizatul Amira and Wan Mohd Kamaluddin, Wan Nur Fatihah and Arzmi, Mohd Hafiz (2021) The prevalence of non-albicans candida in oral squamous cell carcinoma: a review. In: The 4th International Conference on Oral Microbiology and Oral Immunology, 6-8 September 2021, International Islamic University Malaysia. (Unpublished)

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Abstract

The survival rate of oral squamous cell carcinoma (OSCC) has not improved over the past 30 years. Candida albicans has been reported to be the aetiological factor amongst OSCC patients. However, there are limited number of studies that had determined the prevalence of non-albicans Candida (NAC) in OSCC patients compared to C. albicans. Hence, this review aimed to compare the prevalence of C. albicans and non-albicans Candida infections between OSCC patients and healthy individuals. This review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2015 Guidelines. Various databases which include Scopus, PubMed, Science Direct, Public Library of Science (PLOS) databases, and Google Scholar search engine were searched from January 2016 until April 2021 using the keywords ‘Candida colonisation’ or ‘Candida isolation’ and ‘oral candidiasis’ or ‘oral candidosis’ and ‘oral cancer’ or ‘oral squamous cell carcinoma’. Only the original and English articles were included. Joanna Brigg Institute (JBI) Appraisal Tools was used to assess the relevance and results of the published paper. The searching resulted in 6,275 articles identified (Scopus-14, PubMed- 4344, Science Direct- 434, PLOS- 1330, Google Scholar- 153) but only five articles were included in this study. The study showed that Candida spp. were more prevalent in OSCC patients as compared to healthy individuals. Furthermore, a higher number of NAC were isolated from OSCC patients as compared to C. albicans. C. tropicalis is the most prevalent NAC being isolated from OSCC patients. In conclusion, NAC is more prevalent in OSCC as compared to C. albicans, thus the focus should also be made on NAC in OSCC patients.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	7855/93971
Uncontrolled Keywords:	Oral squamous cell carcinoma (OSCC), Candida albicans, non-albicans Candida
Subjects:	Q Science > QR Microbiology R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	23 Nov 2021 11:44
Last Modified:	23 Nov 2021 11:59
URI:	http://irep.iium.edu.my/id/eprint/93971

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