Optimization of supercritical fluid extraction of asiaticoside from Centella asiatica using Central Composite Design (CCD)

Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Bakhtiar, M. Taher and Mohammad, Nurul Farahain (2020) Optimization of supercritical fluid extraction of asiaticoside from Centella asiatica using Central Composite Design (CCD). Separation Science and Technology, 56 (16). pp. 2766-2774. ISSN 0149-6395 E-ISSN 1520-5754

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Abstract

The extraction of asiaticoside was performed using supercritical fluid extraction to produce highly concentrated extracts. The effects of three factors (co-solvent percentage, pressure, and tempera- ture) on the asiaticoside content were screened using the Two-Level Factorial design and optimized using the Central Composite Design. Asiaticoside was extracted following the treatment combina- tions of three parameters, namely co-solvent (5–15%), temperature (70–90°C), and pressure (1–20 MPa). The optimized extraction parameters were identified at 10%, 10.5 MPa, and 80°C for co- solvent percentage, pressure, and temperature, respectively.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Centella asiatica; extraction; asiaticoside; optimization; supercritical fluid extraction
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	26 Aug 2021 15:56
Last Modified:	26 Aug 2021 15:56
URI:	http://irep.iium.edu.my/id/eprint/91754

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