Prevalence and risk factors for menstrual irregularities among systemic lupus erythematosus in rural Malaysia

Nik Ahmad, Nik Nur Fatnoon and Mohamad Shah, Azarisman Shah and Darus, Zainal (2007) Prevalence and risk factors for menstrual irregularities among systemic lupus erythematosus in rural Malaysia. Lupus, 16 (5 Supplement). pp. 122-123. ISSN 0961-2033 E-ISSN 1477-0962

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Abstract

Objectives: The aim of this study was to determine the prevalence and the types of menstrual irregularities among patients with SLE, and to identify factors that influence their development. Methodology: Sixty-one patients with SLE were enrolled into a cross-sectional, observational study. at medical clinics, University Science Malaysia Hospital (Hospital Universiti Sains Malaysia). A total of 120 healthy women were selected randomly to act as the control group. A menstrual questionnaires were administered, vital signs were recorded, and blood was evaluated. A review of past medical records were also undertaken. Results: The mean age (SD) for the study group 33.23 +/- 10.96 years, the majority being ethnic Malay, 75% had severe SLEDAI score on initial presentation and 59 percent were on cyclophosphamide. 49% of study population had menstrual irregularities in which 60% had sustained amenorrhea. 9 patients with sustained amenorrhea had hormonal assay which confirmed diagnosis of premature menopause. Conclusions: This study showed that SLE patients had a higher risk of developing menstrual irregularities to normal /healthy population. The risk was higher in older age group (>30 years old), and those on cyclophosphamide therapy; especially those with a cumulative dose of more than 10 gram. Sustained amenorrhea was the commonest menstrual irregularity and majority of them had confirmed premature menopause. Keywords: Systemic lupus erythematosus, menstrual irregularity, premature menopause

Item Type:	Article (Meeting Abstract)
Additional Information:	3754/88951
Uncontrolled Keywords:	Systemic lupus erythematosus, menstrual irregularity, premature menopause
Subjects:	R Medicine > RC Internal medicine > RC627 Specialties of Internal Medicine-Metabolic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Dr Nik Nur Fatnoon Nik Ahmad
Date Deposited:	22 Mar 2021 08:11
Last Modified:	22 Mar 2021 08:11
URI:	http://irep.iium.edu.my/id/eprint/88951

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