Effects of co-solvent, temperature and pressure on asiaticoside content in supercritical fluid extraction of Centella Asiatica

Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Bakhtiar, M. Taher and Mohammad, Nurul Farahain (2020) Effects of co-solvent, temperature and pressure on asiaticoside content in supercritical fluid extraction of Centella Asiatica. In: 3rd International Conference on Chemistry, Chemical Process and Engineering, 30 September 2020, Jogjakarta. (Unpublished)

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Abstract

Centella asiatica had been reported to possess many biological properties due to the presence of asiaticoside. In this study, the extraction of asiaticoside was done using supercritical fluid extraction as it was believed to produce highly concentrated extracts. This research focused on the effect of co-solvent percentage, pressure and temperature on the asiaticoside content. The effects of different parameters on asiaticoside were screened using Two-Level Factorial and optimized using Central Composite Design. Besides, analysis of variance at p-value < 0.05 was used to scrutinize the significance of the factors. Asiaticoside was extracted following the treatment combinations of three parameters which were co-solvent (5 – 15 %), temperature (70 – 90 °C) and pressure (1 – 20 MPa). The optimized extraction parameters were found at 10 %, 10.5 MPa and 80 °C for co-solvent percentage, pressure and temperature. The overall model was significant (p < 0.05) with acceptable R2 0.9975.

Item Type:	Conference or Workshop Item (Invited Papers)
Additional Information:	5641/84852
Uncontrolled Keywords:	Centella asiatica; extraction; asiaticoside; optimization
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science > Department of Computational and Theoretical Sciences
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	24 Nov 2020 12:20
Last Modified:	24 Nov 2020 12:20
URI:	http://irep.iium.edu.my/id/eprint/84852

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