Optimization of supercritical fluid extraction of asiaticoside from Centella Asiatica using Central Composite Design (CCD)

Ruslan, Fatin Shazwani and Darnis, Deny Susanti and Taher, Muhammad and Mohammad, Nurul Farahain (2020) Optimization of supercritical fluid extraction of asiaticoside from Centella Asiatica using Central Composite Design (CCD). Separation Science and Technology. ISSN 0149-6395 E-ISSN 1520-5754 (In Press)

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Abstract

The extraction of asiaticoside was performed using supercritical fluid extraction to produce highly concentrated extracts. The effects of three factors (co-solvent percentage, pressure, and tempera- ture) on the asiaticoside content were screened using the Two-Level Factorial design and optimized using the Central Composite Design. Asiaticoside was extracted following the treatment combina- tions of three parameters, namely co-solvent (5–15%), temperature (70–90°C), and pressure (1–20 MPa). The optimized extraction parameters were identified at 10%, 10.5 MPa, and 80°C for co- solvent percentage, pressure, and temperature, respectively.

Item Type:	Article (Journal)
Additional Information:	5641/84851
Uncontrolled Keywords:	Centella asiatica; extraction; asiaticoside; optimization; supercritical fluid extraction
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Science > Department of Chemistry Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science > Department of Computational and Theoretical Sciences
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	24 Nov 2020 12:16
Last Modified:	24 Nov 2020 12:16
URI:	http://irep.iium.edu.my/id/eprint/84851

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