MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance

Kun-Lin, Lee and Ng, Simon and Li, Fang and Nordin, Anis Nurashikin and Voiculescu, Ioana (2020) MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance. Biointerphases, 15 (2). pp. 1-3. ISSN 1934-8630 E-ISSN 1559-4106

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Abstract

This paper presents the use of a commercial quartz crystal microbalance (QCM) to investigate live-cell activity in water-based toxic solutions. The QCM used in this research has a resonant frequency of 10 MHz and consists of an AT-cut quartz crystal with gold electrodes on both sides. This QCM was transformed into a functional biosensor by integrating with polydimethylsiloxane culturing chambers. Rainbow trout gill epithelial cells were cultured on the resonators as a sensorial layer. The fluctuation of the resonant frequency, due to the change of cell morphology and adhesion, is an indicator of water toxicity. The shift in the resonant frequency provides information about the viability of the cells after exposure to toxicants. The toxicity result shows distinct responses after exposing cells to 0.526 μM of pentachlorophenol (PCP) solution, which is the Military Exposure Guidelines concentration. This research demonstrated that the QCM is sensitive to a low concentration of PCP and no further modification of the QCM surface was required.

Item Type:	Article (Journal)
Additional Information:	3239/82225
Uncontrolled Keywords:	Quartz Crystal, Microbalance in Biological Surface Science and Soft Matter
Subjects:	T Technology > TK Electrical engineering. Electronics Nuclear engineering T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK4001 Applications of electric power
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering Kulliyyah of Engineering > Department of Electrical and Computer Engineering
Depositing User:	Dr. Anis Nurashikin Nordin
Date Deposited:	24 Aug 2020 17:07
Last Modified:	24 Aug 2020 17:07
URI:	http://irep.iium.edu.my/id/eprint/82225

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