Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production

Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Kok Wai, Lam (2019) Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production. In: 1st Malaysian Association for Cancer Research (MACR) Scientific Conference (1st MSC) 2019, 3th-4th December 2019, MAHSA University, Bandar Saujana Putra, Selangor. (Unpublished)

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Abstract

Prostaglandin E2 (PGE2) is an essential metabolite of the cyclooxygenase pathway in the human body. However, excessive production of PGE2 has been implicated with a variety of inflammatory and cancer diseases. Studies have revealed that blockade of PGE2 production could enhance the innate immune function both in vitro and ex vivo experiments. Hence, this could serve as a useful strategy for preventing and treating inflammation and cancer in related individuals. Natural products have been of great interest for many years, and have provided modern medicine with numerous useful drug leads. One of the families of natural products that has been widely explored for their biological activities is the chromones.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	9020/77275
Uncontrolled Keywords:	Chromone, prostaglandin E2, structure-activity relationship and inflammation
Subjects:	R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Kamal Rullah
Date Deposited:	19 Dec 2019 15:01
Last Modified:	19 Dec 2019 15:01
URI:	http://irep.iium.edu.my/id/eprint/77275

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