IIUM Repository

Dr Kamal Rullah

Assistant Professor

Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy

International Islamic University Malaysia

Medicinal Chemistry, Drug Discovery, Pharmacy

Dr. Kamal Rullah obtained B.Pharm in 2007 from the Sekolah Tinggi Ilmu Farmasi Riau, Apothecary (2008) from the Universitas Andalas and M.Sc (2011) from the Universitas Riau, Indonesia. He earned his Ph.D Medicinal Chemistry in 2017 from Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur and during 2017-2019 he performed postdoctoral research fellow at the Nanotechnology and Catalysis Research Centre (NANOCAT) University of Malaya (UM), working on organic synthesis sulphur-based compound collaboration with leading R&D Europe companies. He joined the academic member at Kulliyah of Pharmacy (KOP), International Islamic University Malaysia (IIUM) in 2019. His research interests are design and synthesis of new-bioactive molecule for application in chemical biology and premore...

Post-Doctoral Research Fellow - University of Malaya (UM) Doctor of Philosophy (Pharmacy) - Medicinal Chemistry, National University of Malaysia (UKM) M.Sc - Masters Degree, Universitas Riau (UNRI) Apothecary/Clinical Pharmacist-Universitas Andalas (UNAND) B.Pharm - Bachelor Degree, Sekolah Tinggi Ilmu Farmasi Riau

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Latest Additions

  1. Salim, Emil and Hori, Aki and Matsubara, Kohei and Takano-Shimizu, Toshiyuki and Pratomo, Andre Rizky and Marianne, Marianne and Syahputra, Armia and Husori, Dadang Irfan and Inoue, Asuka and Abdullah, Maryam Aisyah and Shamsudin, Nur Farisya and Rullah, Kamal and Kuraishi, Takayuki (2025) Detection of human GPCR activity in drosophila S2 cells using the Tango system. International Journal of Molecular Sciences, 26 (1). ISSN 1661-6596 E-ISSN 1422-0067
  2. Putri, Intan Salsabila and Shamsudin, Nur Farisya and Abdullah, Maryam Aisyah and Nurcholis, Mochamad and Imran, Syahrul and Yu, Chai Xin and Tham, Chau Ling and Ibrahim, Zalikha and Taher, Muhammad and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Leong, Sze-Wei and Raharjo, Sentot Joko and Islami, Deri and Huq, AKM Moyeenul (2024) Theoretical investigation of selective inhibitory activity of chromone-based compounds against monoamine oxidase (MAO)-A and -B. Journal of Biomolecular Structure and Dynamics (JBSD). ISSN 0739-1102
  3. Roney, Miah and Huq, A. K. M. Moyeenul and Rullah, Kamal and Zamri, Normaiza and Mohd Aluwi, Mohd Fadhlizil Fasihi (2024) Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors. Cell Biochemistry and Biophysics. ISSN 1085-9195
  4. Yuandani, Yuandani and Jantan, Ibrahim and Septama, Abdi Wira and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Emran, Talhah and Roney, Miah and Khairunnisa, Nur Aini and Shamsudin, Nur Farisya and Abdullah, Maryam Aisyah and Marwa Rani, Haya Luthfiyyah and Al Chaira, Diany Mahabbah and Aulia, Nabila (2024) Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis. Phytotherapy Research, 38 (6). pp. 2931-2961. ISSN 0951418X E-ISSN 1099-1573
  5. Yuda Teruna, Hilwan and Rullah, Kamal and Hendra, Rudi and Utami, Rahayu and Islami, Deri and Mohd Faudzi, Siti Munirah and Mohd Aluwi, Mohd Fadhlizil Fasihi and Lam, Kok Wai (2024) Inhibitory effect of (2S)-Pinocembrin from goniothalamus macrophyllus on the prostaglandin E2 production in macrophage cell lines. Advances in Pharmacological and Pharmaceutical Sciences. ISSN 2633-4690
  6. Rullah, Kamal and Shamsudin, Nur Farisya and Koeberle, Andreas and Tham, Chau Ling and Mohd Aluwi, Mohd Fadhlizil Fasihi and Leong, Sze Wei and Jantan, Ibrahim and Lam, Kok Wai (2024) Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages. Future Medicinal Chemistry, 16 (1). pp. 75-99. ISSN 1756-8927
  7. Shamsudin, Nur Farisya and Leong, Sze-Wei and Koeberle, Andreas and Suriya, Utid and Rungrotmongkol, Thanyada and Chia, Suet Lin and Taher, Muhammad and Haris @ Harith, Muhammad Salahuddin and Alshwyeh, Hussah Abdullah and Alosaimi, Areej A and Mediani, Ahmed and Ilowefah, Muna Abdulsalam and Islami, Deri and Mohd Faudzi, Siti Munirah and Mohd Aluwi, Mohd Fadhlizil Fasihi and Wai, Lam Kok and Rullah, Kamal (2024) A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer. Future Medicinal Chemistry, 16 (15). pp. 1499-1517. ISSN 1756-8919 E-ISSN 1756-8927
  8. Roney, Miah and Khai Voon, Kelvin Wong and Huq, AKM Moyeenul and Rullah, Kamal and Tajuddin, Saiful Nizam and Abd Hamid, Hazrulrizawati and Mohd Aluwi, Mohd Fadhlizil Fasihi (2023) Pharmacophore-based molecular docking of usnic acid derivatives to discover anti-viral drugs against influenza A virus. Journal of Research in Pharmacy, 27 (3). pp. 1021-1038. ISSN 1309-0801 E-ISSN 2630-6344
  9. Fauzi, Ahmad and Saifudin, Azis and Rullah, Kamal (2023) Synthesis of dihydropyrimidinone (DHPM) derivatives through a multicomponent reaction (MCR) and their biological activity. Journal of Medicinal and Chemical Sciences, 6 (8). pp. 1810-1817. E-ISSN 2651-4702
  10. Wong, K.K.V. and Roney, Miah and Uddin, Nazim and Imran, Syahrul and Gazali, Ahmad Mahfuz and Zamri, Normaiza and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi (2023) Usnic acid as potential inhibitors of BCL2 and P13K protein through network pharmacology-based analysis, molecular docking and molecular dynamic simulation. Journal of Biomolecular Structure and Dynamics, 41 (23). pp. 13632-13645. ISSN 0739-1102 E-ISSN 1538-0254
  11. Roney, Miah and Singh, Gagandeep and Huq, A.K.M. Moyeenul and Forid, Md Shaekh and Wan Ishak, Wan Maznah and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Tajuddin, Saiful Nizam (2023) Identification of pyrazole derivatives of usnic acid as novel inhibitor of SARS-CoV-2 main protease through virtual screening approaches. Molecular Biotechnology. pp. 1-11. ISSN 1073-6085 E-ISSN 1559-0305
  12. Yu, Chai Xin and Tan, Jian Wei and Rullah, Kamal and Imran, Syahrul and Tham, Chau Ling (2023) Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles. Journal of Biomolecular Structure and Dynamics. ISSN 0739-1102 E-ISSN 1538-0254
  13. Rullah, Kamal and Roney, Miah and Ibrahim, Zalikha and Shamsudin, Nur Farisya and Islami, Deri and Ahmed, Qamar Uddin and Wai, Lam Kok and Mohd Aluwi, Mohd Fadhlizil Fasihi (2022) Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses. Journal of Computational Biophysics and Chemistry. pp. 1-21. ISSN 2737-4165 E-ISSN 2737-4173 (In Press)
  14. Rullah, Kamal and Shamsudin, Nur Farisya (2022) A promising chromone-based compounds in drug discovery for new anti-inflammatory and anti-cancer drugs. In: International Conference on Contemporary Science and Clinical Pharmacy (ICCSCP) 2022, 26-27 October 2022, Padang-Indonesia. (Unpublished)
  15. Shamsudin, Nur Farisya and Leong, Sze-Wei and Chia, Suet Lin and Suriya, Utid and Rungrotmongkol, Thanyada and Mohd Aluwi, Mohd Fadhlizil Fasihi and Redzwan, Irna Elina and Bakhtiar, M. Taher and Haris @ Harith, Muhammad Salahuddin and Wai, Lam Kok and Rullah, Kamal (2022) Synthesis of flavone-based compounds as ros-dependent apoptosis inducers in colorectal cancer. In: International Conference on Pharmaceutical Sciences ICOPS@IIUM2022, 08-09 August 2022, IIUM, Kuantan., 08-09 August 2022, Kuantan (online). (Unpublished)
  16. Khai Voon, Kelvin Wong and Gazali, Ahmad Mahfuz and Zamri, Normaiza and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and UNSPECIFIED (2022) A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer. Journal of Computational Biophysics and Chemistry, 21 (6). pp. 611-627. ISSN 2737-4165 E-ISSN 2737-4173
  17. Roney, Miah and Huq, AKM Moyeenul and Rullah, Kamal and Abd Hamid, Hazrulrizawati and Imran, Syahrul and Islam, Md. Alimul and Mohd Aluwi, Mohd Fadhlizil Fasihi (2021) Virtual screening-based identification of potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database. Journal of Computational Biophysics and Chemistry, 20 (8). pp. 797-814. ISSN 2737-4165 E-ISSN 2737-4173
  18. Mohd Aluwi, Mohd Fadhlizil Fasihi and Salim, Fatimah and Moyeenul Huq, A.K.M. and Rullah, Kamal and Kok Wai, Lam (2021) In silico functional and structural insight of prenylated pyrazolocurcumin derivative associated with the PGE2 inhibition through mPGES-1 blocking. In: 2nd Postgraduate Symposium on Industrial Science and Technology, SISTEC 2020, 26th August - 27th August 2020, Kuantan, Pahang.
  19. Kamsani, Nurul Huda and Haris @ Harith, Muhammad Salahuddin and Pandey, Manisha and Bakhtiar, M. Taher and Rullah, Kamal (2021) Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: a minireview. Arabian Journal of Chemistry, 14 (7). ISSN 1878-5352
  20. Rullah, Kamal and Gan, Bee Koon and Yong, Chean Yeah and Ho, Kok Lian and Omar, Abdul Rahman and Alitheen, Noorjahan Banu and Tan, Wen Siang (2020) Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles. Scientific Reports, 10 (1). ISSN 2045-2322

Most Viewed Items

Item titleViews
1Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: a minireview937
2Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor827
3Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies823
4Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles817
5Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones781
6Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives775
7Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents769
8Kajian dok molekul mengenai interaksi antara RNA-bergantung RNA polimerase virus denggi dan analog nukleosida = Molecular docking study of the interactions between dengue virus RNA-dependent-RNA polymerase and nucleoside analogues766
9Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-1763
10Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme760
11Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway756
12Insights on the synthesis of asymmetric curcumin derivatives and their biological activities755
13Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production747
14Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment745
15In silico functional and structural insight of prenylated pyrazolocurcumin derivative associated with the PGE2 inhibition through mPGES-1 blocking732
16Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA727
17Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines723
18Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation722
19Effects of tocotrienols on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture710
20Probing the effects of fish oil on the delivery and inflammation-inducing potential of imiquimod699
21Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor694
22Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors666
23Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives664
24Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells652
25Virtual screening-based identification of potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database650
26Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses642
27Synthesis of flavone-based compounds as ros-dependent apoptosis inducers in colorectal cancer598
28A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer556
29A promising chromone-based compounds in drug discovery for new anti-inflammatory and anti-cancer drugs500
30Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles472