IIUM Repository

Dr Kamal Rullah

Assistant Professor

Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy

International Islamic University Malaysia

Medicinal Chemistry, Drug Discovery, Pharmacy

Dr. Kamal Rullah obtained B.Pharm in 2007 from the Sekolah Tinggi Ilmu Farmasi Riau, Apothecary (2008) from the Universitas Andalas and M.Sc (2011) from the Universitas Riau, Indonesia. He earned his Ph.D Medicinal Chemistry in 2017 from Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur and during 2017-2019 he performed postdoctoral research fellow at the Nanotechnology and Catalysis Research Centre (NANOCAT) University of Malaya (UM), working on organic synthesis sulphur-based compound collaboration with leading R&D Europe companies. He joined the academic member at Kulliyah of Pharmacy (KOP), International Islamic University Malaysia (IIUM) in 2019. His research interests are design and synthesis of new-bioactive molecule for application in chemical biology and premore...

Post-Doctoral Research Fellow - University of Malaya (UM) Doctor of Philosophy (Pharmacy) - Medicinal Chemistry, National University of Malaysia (UKM) M.Sc - Masters Degree, Universitas Riau (UNRI) Apothecary/Clinical Pharmacist-Universitas Andalas (UNAND) B.Pharm - Bachelor Degree, Sekolah Tinggi Ilmu Farmasi Riau

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Latest Additions

  1. Roney, Miah and Singh, Gagandeep and Huq, A.K.M. Moyeenul and Forid, Md Shaekh and Wan Ishak, Wan Maznah and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Tajuddin, Saiful Nizam (2023) Identification of pyrazole derivatives of usnic acid as novel inhibitor of SARS-CoV-2 main protease through virtual screening approaches. Molecular Biotechnology. pp. 1-11. ISSN 1073-6085 E-ISSN 1559-0305
  2. Yu, Chai Xin and Tan, Jian Wei and Rullah, Kamal and Imran, Syahrul and Tham, Chau Ling (2023) Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles. Journal of Biomolecular Structure and Dynamics. ISSN 0739-1102 E-ISSN 1538-0254
  3. Rullah, Kamal and Roney, Miah and Ibrahim, Zalikha and Shamsudin, Nur Farisya and Islami, Deri and Ahmed, Qamar Uddin and Wai, Lam Kok and Mohd Aluwi, Mohd Fadhlizil Fasihi (2022) Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses. Journal of Computational Biophysics and Chemistry. pp. 1-21. ISSN 2737-4165 E-ISSN 2737-4173 (In Press)
  4. Rullah, Kamal and Shamsudin, Nur Farisya (2022) A promising chromone-based compounds in drug discovery for new anti-inflammatory and anti-cancer drugs. In: International Conference on Contemporary Science and Clinical Pharmacy (ICCSCP) 2022, 26-27 October 2022, Padang-Indonesia. (Unpublished)
  5. Shamsudin, Nur Farisya and Leong, Sze-Wei and Chia, Suet Lin and Suriya, Utid and Rungrotmongkol, Thanyada and Mohd Aluwi, Mohd Fadhlizil Fasihi and Redzwan, Irna Elina and Bakhtiar, M. Taher and Haris @ Harith, Muhammad Salahuddin and Wai, Lam Kok and Rullah, Kamal (2022) Synthesis of flavone-based compounds as ros-dependent apoptosis inducers in colorectal cancer. In: International Conference on Pharmaceutical Sciences ICOPS@IIUM2022, 08-09 August 2022, IIUM, Kuantan., 08-09 August 2022, Kuantan (online). (Unpublished)
  6. Khai Voon, Kelvin Wong and Gazali, Ahmad Mahfuz and Zamri, Normaiza and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and UNSPECIFIED (2022) A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer. Journal of Computational Biophysics and Chemistry, 21 (6). pp. 611-627. ISSN 2737-4165 E-ISSN 2737-4173
  7. Roney, Miah and Huq, AKM Moyeenul and Rullah, Kamal and Abd Hamid, Hazrulrizawati and Imran, Syahrul and Islam, Md. Alimul and Mohd Aluwi, Mohd Fadhlizil Fasihi (2021) Virtual screening-based identification of potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database. Journal of Computational Biophysics and Chemistry, 20 (8). pp. 797-814. ISSN 2737-4165 E-ISSN 2737-4173
  8. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Salim, Fatimah and Moyeenul Huq, A.K.M. and Kok Wai, Lam (2021) In Silico Functional and Structural Insight of Prenylated Pyrazolocurcumin Derivative Associated with the PGE2 Inhibition through mPGES-1 Blocking. Materials Science Forum, 1025. pp. 219-223. ISSN 1662-9752
  9. Kamsani, Nurul Huda and Haris @ Harith, Muhammad Salahuddin and Pandey, Manisha and Taher, Muhammad and Rullah, Kamal (2021) Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: A minireview. Arabian Journal of Chemistry, 14 (7). ISSN 1878-5352
  10. Rullah, Kamal and Gan, Bee Koon and Yong, Chean Yeah and Ho, Kok Lian and Omar, Abdul Rahman and Alitheen, Noorjahan Banu and Tan, Wen Siang (2020) Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles. Scientific Reports, 10 (1). ISSN 2045-2322
  11. Sanphetchaloemchok, Pitipat and Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Wai, Lam Kok (2020) Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-1. In: Industrial science and technology : symposium on industrial science and technology (SISTEC 2019). Materials science forum, 981 . Trans Tech Publications Ltd, Switzerland, pp. 247-252. ISBN 978-303571664-1
  12. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Kok Wai, Lam (2019) Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production. In: 1st Malaysian Association for Cancer Research (MACR) Scientific Conference (1st MSC) 2019, 3th-4th December 2019, MAHSA University, Bandar Saujana Putra, Selangor. (Unpublished)
  13. Mohd Faudzi, Siti Munirah and Abdullah, Maryam Aisyah and Abdull Manap, Mohd Rashidi and Ismail, Ahmad Zaidi and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Mazila Ramli, Aizi Nor and Abas, Faridah and Lajis, Nordin H. (2020) Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies. Bioorganic Chemistry, 94. pp. 1-12. ISSN 0045-2068
  14. Rullah, Malaysia and Mohd Aluwi, Mohd Fadhlizil Fasihi and Khor, Poh Yen and Kok Wai, Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234
  15. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Koeberle, Andreas and Werz, Oliver and Abdul Razak, Nur Sakinah and Wei, Leong Sze and Salim, Fatimah and Ismail, Nor Hadiani and Jantan, Ibrahim and Wai, Lam Kok (2019) Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA. Journal of Molecular Structure, 1196. pp. 844-850. ISSN 0022-2860
  16. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Yamin, Bohari M. and Juan, Joon Ching and Wai, Lam Kok (2019) Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones. Asian Journal of Organic Chemistry, 8 (8). pp. 1174-1193. ISSN 2193-5815
  17. Huq, AKM Moyeenul and Wai, Lam Kok and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Stanslas, Johnson and Jamal, Jamia Azdina (2019) Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway. Chemical Biology and Drug Design, 93 (3). pp. 1-10. ISSN 1747-0285 (In Press)
  18. Ng, Chean Hui and Rullah, Kamal and Abas, Faridah and Lam, Kok Wai and Ismail, Intan Safinar and Jamaludin, Fadzureena and Shaari, Khozirah (2018) Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment. Molecules, 23 (10). pp. 1-19. ISSN 1420-3049
  19. Abdullah, Nor Nadirah and Rullah, Kamal and Wai, Lam Kok and Jasamai, Marlina (2018) Kajian dok molekul mengenai interaksi antara RNA-bergantung RNA polimerase virus denggi dan analog nukleosida = Molecular docking study of the interactions between dengue virus RNA-dependent-RNA polymerase and nucleoside analogues. Sains Malaysiana, 47 (3). pp. 517-522. ISSN 0126-6039
  20. Rullah, Kamal and Khye, Saw Phin and Ang, Serene and Mohd Aluwi, Mohd Fadhlizil Fasihi and Lam, Kok Wai (2018) Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme. Jurnal Sains Kesihatan Malaysia (JSKM), 16 (1). pp. 135-143. ISSN 2289-4535

Most Viewed Items

Item titleViews
1Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: A minireview444
2Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies429
3Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles416
4Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway409
5Kajian dok molekul mengenai interaksi antara RNA-bergantung RNA polimerase virus denggi dan analog nukleosida = Molecular docking study of the interactions between dengue virus RNA-dependent-RNA polymerase and nucleoside analogues404
6Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor402
7Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones401
8Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme390
9Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment388
10Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents381
11Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-1380
12Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA372
13Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation371
14Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines363
15Effects of tocotrienols on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture360
16Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives359
17Insights on the synthesis of asymmetric curcumin derivatives and their biological activities355
18Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production354
19Probing the effects of fish oil on the delivery and inflammation-inducing potential of imiquimod346
20Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor336
21Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells335
22In Silico Functional and Structural Insight of Prenylated Pyrazolocurcumin Derivative Associated with the PGE2 Inhibition through mPGES-1 Blocking320
23Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives317
24Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors310
25Virtual screening-based identification of potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database224
26A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer108
27Synthesis of flavone-based compounds as ros-dependent apoptosis inducers in colorectal cancer101
28A promising chromone-based compounds in drug discovery for new anti-inflammatory and anti-cancer drugs96
29Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses91
30Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles10