IIUM Repository

Dr Kamal Rullah

Assistant Professor

Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy

International Islamic University Malaysia

Medicinal Chemistry, Drug Discovery, Pharmacy

Dr. Kamal Rullah obtained B.Pharm in 2007 from the Sekolah Tinggi Ilmu Farmasi Riau, Apothecary (2008) from the Universitas Andalas and M.Sc (2011) from the Universitas Riau, Indonesia. He earned his Ph.D Medicinal Chemistry in 2017 from Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur and during 2017-2019 he performed postdoctoral research fellow at the Nanotechnology and Catalysis Research Centre (NANOCAT) University of Malaya (UM), working on organic synthesis sulphur-based compound collaboration with leading R&D Europe companies. He joined the academic member at Kulliyah of Pharmacy (KOP), International Islamic University Malaysia (IIUM) in 2019. His research interests are design and synthesis of new-bioactive molecule for application in chemical biology and premore...

Post-Doctoral Research Fellow - University of Malaya (UM) Doctor of Philosophy (Pharmacy) - Medicinal Chemistry, National University of Malaysia (UKM) M.Sc - Masters Degree, Universitas Riau (UNRI) Apothecary/Clinical Pharmacist-Universitas Andalas (UNAND) B.Pharm - Bachelor Degree, Sekolah Tinggi Ilmu Farmasi Riau

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Latest Additions

  1. Rullah, Kamal and Shamsudin, Nur Farisya and Koeberle, Andreas and Tham, Chau Ling and Mohd Aluwi, Mohd Fadhlizil Fasihi and Leong, Sze Wei and Jantan, Ibrahim and Lam, Kok Wai (2024) Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages. Future Medicinal Chemistry, 16 (1). pp. 75-99. ISSN 1756-8927
  2. Shamsudin, Nur Farisya and Leong, Sze-Wei and Koeberle, Andreas and Suriya, Utid and Rungrotmongkol, Thanyada and Chia, Suet Lin and Taher, Muhammad and Haris @ Harith, Muhammad Salahuddin and Alshwyeh, Hussah Abdullah and Alosaimi, Areej A and Mediani, Ahmed and Ilowefah, Muna Abdulsalam and Islami, Deri and Mohd Faudzi, Siti Munirah and Mohd Aluwi, Mohd Fadhlizil Fasihi and Wai, Lam Kok and Rullah, Kamal (2024) A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer. Future Medicinal Chemistry, 16 (15). pp. 1499-1517. ISSN 1756-8919 E-ISSN 1756-8927
  3. Roney, Miah and Khai Voon, Kelvin Wong and Huq, AKM Moyeenul and Rullah, Kamal and Tajuddin, Saiful Nizam and Abd Hamid, Hazrulrizawati and Mohd Aluwi, Mohd Fadhlizil Fasihi (2023) Pharmacophore-based molecular docking of usnic acid derivatives to discover anti-viral drugs against influenza A virus. Journal of Research in Pharmacy, 27 (3). pp. 1021-1038. ISSN 1309-0801 E-ISSN 2630-6344
  4. Fauzi, Ahmad and Saifudin, Azis and Rullah, Kamal (2023) Synthesis of dihydropyrimidinone (DHPM) derivatives through a multicomponent reaction (MCR) and their biological activity. Journal of Medicinal and Chemical Sciences, 6 (8). pp. 1810-1817. E-ISSN 2651-4702
  5. Wong, K.K.V. and Roney, Miah and Uddin, Nazim and Imran, Syahrul and Gazali, Ahmad Mahfuz and Zamri, Normaiza and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi (2023) Usnic acid as potential inhibitors of BCL2 and P13K protein through network pharmacology-based analysis, molecular docking and molecular dynamic simulation. Journal of Biomolecular Structure and Dynamics, 41 (23). pp. 13632-13645. ISSN 0739-1102 E-ISSN 1538-0254
  6. Roney, Miah and Singh, Gagandeep and Huq, A.K.M. Moyeenul and Forid, Md Shaekh and Wan Ishak, Wan Maznah and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Tajuddin, Saiful Nizam (2023) Identification of pyrazole derivatives of usnic acid as novel inhibitor of SARS-CoV-2 main protease through virtual screening approaches. Molecular Biotechnology. pp. 1-11. ISSN 1073-6085 E-ISSN 1559-0305
  7. Yu, Chai Xin and Tan, Jian Wei and Rullah, Kamal and Imran, Syahrul and Tham, Chau Ling (2023) Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles. Journal of Biomolecular Structure and Dynamics. ISSN 0739-1102 E-ISSN 1538-0254
  8. Rullah, Kamal and Roney, Miah and Ibrahim, Zalikha and Shamsudin, Nur Farisya and Islami, Deri and Ahmed, Qamar Uddin and Wai, Lam Kok and Mohd Aluwi, Mohd Fadhlizil Fasihi (2022) Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses. Journal of Computational Biophysics and Chemistry. pp. 1-21. ISSN 2737-4165 E-ISSN 2737-4173 (In Press)
  9. Rullah, Kamal and Shamsudin, Nur Farisya (2022) A promising chromone-based compounds in drug discovery for new anti-inflammatory and anti-cancer drugs. In: International Conference on Contemporary Science and Clinical Pharmacy (ICCSCP) 2022, 26-27 October 2022, Padang-Indonesia. (Unpublished)
  10. Shamsudin, Nur Farisya and Leong, Sze-Wei and Chia, Suet Lin and Suriya, Utid and Rungrotmongkol, Thanyada and Mohd Aluwi, Mohd Fadhlizil Fasihi and Redzwan, Irna Elina and Bakhtiar, M. Taher and Haris @ Harith, Muhammad Salahuddin and Wai, Lam Kok and Rullah, Kamal (2022) Synthesis of flavone-based compounds as ros-dependent apoptosis inducers in colorectal cancer. In: International Conference on Pharmaceutical Sciences ICOPS@IIUM2022, 08-09 August 2022, IIUM, Kuantan., 08-09 August 2022, Kuantan (online). (Unpublished)
  11. Khai Voon, Kelvin Wong and Gazali, Ahmad Mahfuz and Zamri, Normaiza and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and UNSPECIFIED (2022) A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer. Journal of Computational Biophysics and Chemistry, 21 (6). pp. 611-627. ISSN 2737-4165 E-ISSN 2737-4173
  12. Roney, Miah and Huq, AKM Moyeenul and Rullah, Kamal and Abd Hamid, Hazrulrizawati and Imran, Syahrul and Islam, Md. Alimul and Mohd Aluwi, Mohd Fadhlizil Fasihi (2021) Virtual screening-based identification of potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database. Journal of Computational Biophysics and Chemistry, 20 (8). pp. 797-814. ISSN 2737-4165 E-ISSN 2737-4173
  13. Mohd Aluwi, Mohd Fadhlizil Fasihi and Salim, Fatimah and Moyeenul Huq, A.K.M. and Rullah, Kamal and Kok Wai, Lam (2021) In silico functional and structural insight of prenylated pyrazolocurcumin derivative associated with the PGE2 inhibition through mPGES-1 blocking. In: 2nd Postgraduate Symposium on Industrial Science and Technology, SISTEC 2020, 26th August - 27th August 2020, Kuantan, Pahang.
  14. Kamsani, Nurul Huda and Haris @ Harith, Muhammad Salahuddin and Pandey, Manisha and Bakhtiar, M. Taher and Rullah, Kamal (2021) Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: a minireview. Arabian Journal of Chemistry, 14 (7). ISSN 1878-5352
  15. Rullah, Kamal and Gan, Bee Koon and Yong, Chean Yeah and Ho, Kok Lian and Omar, Abdul Rahman and Alitheen, Noorjahan Banu and Tan, Wen Siang (2020) Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles. Scientific Reports, 10 (1). ISSN 2045-2322
  16. Sanphetchaloemchok, Pitipat and Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Wai, Lam Kok (2020) Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-1. In: Industrial science and technology : symposium on industrial science and technology (SISTEC 2019). Materials science forum, 981 . Trans Tech Publications Ltd, Switzerland, pp. 247-252. ISBN 978-303571664-1
  17. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Kok Wai, Lam (2019) Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production. In: 1st Malaysian Association for Cancer Research (MACR) Scientific Conference (1st MSC) 2019, 3th-4th December 2019, MAHSA University, Bandar Saujana Putra, Selangor. (Unpublished)
  18. Mohd Faudzi, Siti Munirah and Abdullah, Maryam Aisyah and Abdull Manap, Mohd Rashidi and Ismail, Ahmad Zaidi and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Mazila Ramli, Aizi Nor and Abas, Faridah and Lajis, Nordin H. (2020) Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies. Bioorganic Chemistry, 94. pp. 1-12. ISSN 0045-2068
  19. Rullah, Malaysia and Mohd Aluwi, Mohd Fadhlizil Fasihi and Khor, Poh Yen and Kok Wai, Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234
  20. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Koeberle, Andreas and Werz, Oliver and Abdul Razak, Nur Sakinah and Wei, Leong Sze and Salim, Fatimah and Ismail, Nor Hadiani and Jantan, Ibrahim and Wai, Lam Kok (2019) Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA. Journal of Molecular Structure, 1196. pp. 844-850. ISSN 0022-2860

Most Viewed Items

Item titleViews
1Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: a minireview833
2Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor763
3Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies742
4Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles731
5Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents708
6Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives694
7Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones694
8Kajian dok molekul mengenai interaksi antara RNA-bergantung RNA polimerase virus denggi dan analog nukleosida = Molecular docking study of the interactions between dengue virus RNA-dependent-RNA polymerase and nucleoside analogues687
9Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-1682
10Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme680
11Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway672
12Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production669
13Insights on the synthesis of asymmetric curcumin derivatives and their biological activities667
14Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA661
15Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment658
16Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation655
17Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines651
18In silico functional and structural insight of prenylated pyrazolocurcumin derivative associated with the PGE2 inhibition through mPGES-1 blocking641
19Effects of tocotrienols on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture640
20Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor624
21Probing the effects of fish oil on the delivery and inflammation-inducing potential of imiquimod621
22Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells594
23Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors591
24Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives590
25Virtual screening-based identification of potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database562
26Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses554
27Synthesis of flavone-based compounds as ros-dependent apoptosis inducers in colorectal cancer511
28A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer465
29A promising chromone-based compounds in drug discovery for new anti-inflammatory and anti-cancer drugs417
30Identification of pyrazole derivatives of usnic acid as novel inhibitor of SARS-CoV-2 main protease through virtual screening approaches390