IIUM Repository

Dr Kamal Rullah

Assistant Professor

Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy

International Islamic University Malaysia

Medicinal Chemistry, Drug Discovery, Pharmacy

Dr. Kamal Rullah obtained B.Pharm in 2007 from the Sekolah Tinggi Ilmu Farmasi Riau, Apothecary (2008) from the Universitas Andalas and M.Sc (2011) from the Universitas Riau, Indonesia. He earned his Ph.D Medicinal Chemistry in 2017 from Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur and during 2017-2019 he performed postdoctoral research fellow at the Nanotechnology and Catalysis Research Centre (NANOCAT) University of Malaya (UM), working on organic synthesis sulphur-based compound collaboration with leading R&D Europe companies. He joined the academic member at Kulliyah of Pharmacy (KOP), International Islamic University Malaysia (IIUM) in 2019. His research interests are design and synthesis of new-bioactive molecule for application in chemical biology and premore...

Post-Doctoral Research Fellow - University of Malaya (UM) Doctor of Philosophy (Pharmacy) - Medicinal Chemistry, National University of Malaysia (UKM) M.Sc - Masters Degree, Universitas Riau (UNRI) Apothecary/Clinical Pharmacist-Universitas Andalas (UNAND) B.Pharm - Bachelor Degree, Sekolah Tinggi Ilmu Farmasi Riau

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Latest Additions

  1. Sanphetchaloemchok, Pitipat and Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Wai, Lam Kok (2020) Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-1. In: Industrial science and technology : symposium on industrial science and technology (SISTEC 2019). Materials science forum, 981 . Trans Tech Publications Ltd, Switzerland, pp. 247-252. ISBN 978-303571664-1
  2. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Kok Wai, Lam (2019) Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production. In: 1st Malaysian Association for Cancer Research (MACR) Scientific Conference (1st MSC) 2019, 3th-4th December 2019, MAHSA University, Bandar Saujana Putra, Selangor. (Unpublished)
  3. Mohd Faudzi, Siti Munirah and Abdullah, Maryam Aisyah and Abdull Manap, Mohd Rashidi and Ismail, Ahmad Zaidi and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Mazila Ramli, Aizi Nor and Abas, Faridah and Lajis, Nordin H. (2020) Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies. Bioorganic Chemistry, 94. pp. 1-12. ISSN 0045-2068
  4. Rullah, Malaysia and Mohd Aluwi, Mohd Fadhlizil Fasihi and Khor, Poh Yen and Kok Wai, Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234
  5. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Koeberle, Andreas and Werz, Oliver and Abdul Razak, Nur Sakinah and Wei, Leong Sze and Salim, Fatimah and Ismail, Nor Hadiani and Jantan, Ibrahim and Wai, Lam Kok (2019) Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA. Journal of Molecular Structure, 1196. pp. 844-850. ISSN 0022-2860
  6. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Yamin, Bohari M. and Juan, Joon Ching and Wai, Lam Kok (2019) Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones. Asian Journal of Organic Chemistry, 8 (8). pp. 1174-1193. ISSN 2193-5815
  7. Huq, AKM Moyeenul and Wai, Lam Kok and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Stanslas, Johnson and Jamal, Jamia Azdina (2019) Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway. Chemical Biology and Drug Design, 93 (3). pp. 1-10. ISSN 1747-0285 (In Press)
  8. Ng, Chean Hui and Rullah, Kamal and Abas, Faridah and Lam, Kok Wai and Ismail, Intan Safinar and Jamaludin, Fadzureena and Shaari, Khozirah (2018) Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment. Molecules, 23 (10). pp. 1-19. ISSN 1420-3049
  9. Abdullah, Nor Nadirah and Rullah, Kamal and Wai, Lam Kok and Jasamai, Marlina (2018) Kajian dok molekul mengenai interaksi antara RNA-bergantung RNA polimerase virus denggi dan analog nukleosida = Molecular docking study of the interactions between dengue virus RNA-dependent-RNA polymerase and nucleoside analogues. Sains Malaysiana, 47 (3). pp. 517-522. ISSN 0126-6039
  10. Rullah, Kamal and Khye, Saw Phin and Ang, Serene and Mohd Aluwi, Mohd Fadhlizil Fasihi and Lam, Kok Wai (2018) Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme. Jurnal Sains Kesihatan Malaysia (JSKM), 16 (1). pp. 135-143. ISSN 2289-4535
  11. Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Haque, Md. Areeful and Yamin, Bohari M. and Ahmad, Waqas and Amjad, Muhammad Wahab and Leong, Sze Wei and Fahmizar, Nurul Amira and Jalil, Juriyati and Abas, Faridah and Ismail, Nor Hadiani and Jantan, Ibrahim and Lam, Kok Wai (2017) Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives. Medicinal Chemistry Research, 26 (12). pp. 3323-3335. ISSN 1054-2523 E-ISSN 1554-8120
  12. Chia, Ling Li and Jantan, Ibrahim and Chua, Kien Hui and Lam, Kok Wai and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi (2016) Effects of tocotrienols on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture. Frontiers in Pharmacology, 7. pp. 1-17. ISSN 1663-9812
  13. Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Yamin, Bohari M. and Leong, Sze Wei and Abdul Bahari, Mohd Nazri and Lim, Sock Jin and Mohd Faudzi, Siti Munirah and Jalil, Juriyati and Abas, Faridah and Mohd Fauzi, Norsyahida and Ismail, Nor Hadiani and Jantan, Ibrahim and Lam, Kok Wai (2016) Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines. Bioorganic & Medicinal Chemistry Letters, 26 (10). pp. 2531-2538. ISSN 0960-894X
  14. Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Tan, Huan Huan and Chan, Kok Meng and Tan, Si Jie and Leong, Sze Wei and Mansor, Ahmad Hasnan and Yamin, Bohari M. and Lam, Kok Wai (2016) Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells. RSC Advances, 6 (76). pp. 72177-72184. ISSN 2046-2069
  15. Leong, Sze Wei and Mohd Faudzi, Siti Munirah Mohd Faudzi and Abas, Faridah and Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Lam, Kok Wai and Abdul Bahari, Mohd Nazri and Ahmad, Syahida and Tham, Chau Ling and Shaari, Khozirah and Lajis, Nordin H. (2015) Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives. Bioorganic & Medicinal Chemistry Letters, 25 (16). pp. 3330-3337. ISSN 0960-894X
  16. Rehman, Khurram and Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Lam, Kok Wai and Mohd Amin, Mohd Cairul Iqbal and Zulfakar, Mohd Hanif (2015) Probing the effects of fish oil on the delivery and inflammation-inducing potential of imiquimod. International Journal of Pharmaceutics, 490. pp. 131-141. ISSN 0378-5173
  17. Mohd Faudzi, Siti Munirah Mohd Faudzi and Leong, Sze Wei and Abas, Faridah and Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Lam, Kok Wai and Ahmad, Syahida and Ling Tham, Chau Ling Tham and Lajis, Nordin H. (2015) Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors. Medicinal Chemistry Communication, 6. pp. 1069-1080. ISSN 2040-2511
  18. Leong, Sze Wei and Mohd Faudzi, Siti Munirah and Abas, Faridah and Mohd Aluwi, Mohd Fadhlizil Fasihi and Rullah, Kamal and Lam, Kok Wai and Abdul Bahari, Mohd Nazri and Ahmad, Syahida and Chau, Ling Tham and Shaari, Khozirah and Lajis, Nordin H. (2014) Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents. Molecules, 19 (10). pp. 16058-16081. E-ISSN 1420-3049
  19. Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and M.Yamin, Bohari and Baharuddin, Mohd Syukri and Ismail, Nor Hadiani and YudaTeruna, Hilwan and Abbas Bukhari, Syed Nasir and Jantan, Ibrahim and Jalil, Juriyati and Husain, Khairana and Lam, Kok Wai (2015) Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor. Journal of Molecular Structure, 1081. pp. 51-61. ISSN 0022-2860
  20. Chean, Hui Ng and Rullah, Kamal and Mohd Aluwi, Mohd Fadhlizil Fasihi and Abas, Faridah and Kok, Wai Lam and Ismail, Intan Safinar and Narayanaswamy, Radhakrishnan and Jamaludin, Fadzureena and Shaari, Khozirah (2014) Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor. Molecules, 19 (8). pp. 11645-11659. ISSN 1420-3049

Most Viewed Items

Item titleViews
1Insights on the synthesis of asymmetric curcumin derivatives and their biological activities157
2Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives137
3Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation135
4Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor129
5Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives129
6Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor127
7Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents125
8Effects of tocotrienols on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture118
9Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines115
10Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors112
11Probing the effects of fish oil on the delivery and inflammation-inducing potential of imiquimod112
12Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells112
13Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme102
14Kajian dok molekul mengenai interaksi antara RNA-bergantung RNA polimerase virus denggi dan analog nukleosida = Molecular docking study of the interactions between dengue virus RNA-dependent-RNA polymerase and nucleoside analogues99
15Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA94
16Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones90
17Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway89
18Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies87
19Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment77
20Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production73
21Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-116