Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility

Samsudin, Nurhusna and Hashim, Yumi Zuhanis Has-Yun and Arifin, Mohd Azmir and Mel, Maizirwan and Mohd. Salleh, Hamzah (2018) Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility. In: International Conference on Halal Innovations in Products and Services 2018 (i-CHIPS 2018), 13th -14th July 2018, Songkla, Thailand.

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Abstract

Oil/water emulsion solvent evaporation method was employed to fabricate PCL microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system and gelatin. The porous network channels were generated inside the microcarrier by introducing camphene. The average pore size of 11.74±8.32 μm was obtained with the concentration of 20% (w/v) of camphene. The porous PCL microcarrier was further tailored with gelatin through surface treatment with UV/O3 system and gelatin immobilization. Vero cells attach and proliferate well on the gelatin coated porous PCL microcarrier with maximum cell number of 3.90 x 105 cells/ml as compared to cell proliferation on UV/O3 treated porous PCL microcarrier (1.83 x 105 cells/ml). The developed halal microcarrier may be potentially applicable as a cell delivery scaffold for cell tissue culture and tissue engineering application

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	3774/66282
Uncontrolled Keywords:	Halal, porous microcarrier, UV/O3, treatment, microcarrier cell culture
Subjects:	Q Science > Q Science (General) T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART) Kulliyyah of Engineering Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	DR YUMI ZUHANIS HAS-YUN HASHIM
Date Deposited:	02 Oct 2018 16:49
Last Modified:	08 Feb 2023 11:22
URI:	http://irep.iium.edu.my/id/eprint/66282

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