Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications

Shahbuddin, Munira and Ahmad Puat, Nur Najihah and Mirghani, Mohamed Elwathig Saeed and Ahmad Raus, Raha (2016) Natural silk of Pholcus phalangioides, a common home spider species for wound healing applications. In: International Conference for Innovation in Biomedical Engineering and Life Sciences, ICIBEL 2015, 6th-8th Dec. 2015, Putrajaya.

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Abstract

Spider silk contains peptides and biomolecules that able to stimulate and improve conditions of wound healing. In this study, we report the potential use of natural silk from common home spider, Pholcus phalangioides, on human keratinocyte cell line (HaCaT) and teeth pulp stem cell’s proliferation and migration. The aim of this study was to examine the range of silk concentrations and their biological effects on the different type of cells. Our study showed that the silk is biocompatible and stimulated the proliferation of HaCaT and teeth pulp stem cells in a dose dependent manner after 24 and 48 hours. Selective effect of cellular migration was observed when the spider silk did not affect the migration of teeth pulp stem cells but only stimulated the migration of HaCaT after 24 hours. The ability of spider silk to stimulate cellular metabolic activity and migration could benefit research and development of biologically active wound dressings. © International Federation for Medical and Biological Engineering 2016.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	5437/58732
Uncontrolled Keywords:	Hacat, Teeth pulp stem cells, Spider silk, Wound healing and cell migration
Subjects:	T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Dr Munira Shahbuddin
Date Deposited:	25 Aug 2019 16:06
Last Modified:	25 Aug 2019 16:06
URI:	http://irep.iium.edu.my/id/eprint/58732

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