STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies

Xudong, Zhang and Nordin, Anis Nurashikin and Li, Fang and Voiculescu, Ioana R. (2016) STRETCHABLE lab-on-chip device with impedance spectroscopy capability for mammalian cell studies. In: ASME 2016 International Mechanical Engineering Congress and Exposition, IMECE 2016, 11th-17th November 2016, Phoenix, United States.

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Abstract

This paper presents the fabrication and testing of electric cellsubstrate impedance spectroscopy (ECIS) electrodes on a stretchable membrane. This is the first time when ECIS electrodes were fabricated on a stretchable substrate and ECIS measurements on mammalian cells exposed to cyclic strain of 10% were successfully demonstrated. A chemical was used to form strong chemical bond between gold electrodes of ECIS sensor and polymer membrane, which enable the electrodes keep good conductive ability during cyclic stretch. The stretchable membrane integrated with the ECIS sensor can simulate and replicate the dynamic environment of organism and enable the analysis of the cells activity involved in cells attachment and proliferation in vitro. Bovine aortic endothelial cells (BAEC) were used to evaluate the endothelial function influenced by mechanical stimuli in this research because they undergo in vivo cyclic physiologic elongation produced by the blood circulation in the arteries. Copyright © 2016 by ASME.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	3239/53868
Uncontrolled Keywords:	Electrochemical impedance spectroscopy
Subjects:	T Technology > TJ Mechanical engineering and machinery > TJ241 Machine construction (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Mechanical Engineering
Depositing User:	Dr. Anis Nurashikin Nordin
Date Deposited:	25 Aug 2019 16:30
Last Modified:	25 Aug 2019 16:30
URI:	http://irep.iium.edu.my/id/eprint/53868

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