Cholesterol lowering in intermediate-risk persons without cardiovascular disease

Yusuf, Salim and Bosch, Jackie and Dagenais, Gilles and Jun, Zhu and Xavier, Denis and Lisheng, Liu and Md Aris, Mohd Aznan and Mohd Shah, Azarisman Shah and ., et. al (2016) Cholesterol lowering in intermediate-risk persons without cardiovascular disease. New England Journal of Medicine, 374 (21). pp. 2021-2031. ISSN 0028-4793 E-ISSN 1533-4406

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Abstract

Previous trials have shown that the use of statins to lower cholesterol reduces the risk of cardiovascular events among persons without cardiovascular disease. Those trials have involved persons with elevated lipid levels or inflammatory markers and involved mainly white persons. It is unclear whether the benefits of statins can be extended to an intermediate-risk, ethnically diverse population without cardiovascular disease. In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants in 21 countries who did not have cardiovascular disease and were at intermediate risk to receive rosuvastatin at a dose of 10 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included revascularization, heart failure, and resuscitated cardiac arrest. The median follow-up was 5.6 years.

Item Type:	Article (Journal)
Additional Information:	4632/50353
Uncontrolled Keywords:	cholesterol lowering
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RJ Pediatrics R Medicine > RZ Other systems of medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	SR NUR FARHANA LATFI
Date Deposited:	30 May 2016 09:28
Last Modified:	19 Oct 2017 20:26
URI:	http://irep.iium.edu.my/id/eprint/50353

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