Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association?

Hasmoni, Mohamed Hadzri and Salleh, Rosemi and Jaafar, Khairul Azhar and Jaafar, Mohd. Hanizam and Abas, Ariff (2011) Steatohepatitis and fibrosis in chronic Hepatitis C patients: is there any association? Hepatology International, 5 (1). pp. 312-313. ISSN 1936-0533

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Abstract

Background: Hepatic steatosis and disturbances in lipid metabolism has been identified as one of the metabolic disorders in hepatitis C (HCV) infection. This study was to examine the possible association of steatohepatitis with the degree of fibrosis in chronic HCV patients. Methods: Retrospective analysis of data from 72 patients with chronic HCV who underwent liver biopsy from January 2008 to March 2010 in two tertiary hospitals in Malaysia was performed. Patients’ demographic data and their body mass index (BMI), liver function tests and lipid profiles, histological findings of steatosis,staging and grading of biopsy specimen were made. Staging and grading of liver disease was done using modified histological activity index staging (score 0–6) and grading (score 0–18) respectively.Univariate analysis was done to assess the association between the degree of fibrosis and steatohepatitis. Results: 79.2% were males and the mean age for the study population was 40.7 ± 12.0 years. There were 13.9 and 9.7% cases of coinfection with HIV and hepatitis B respectively, while 76.4% patientswere infected with HCV alone. The table showed the superimposed steatohepatitis that was present with severe fibrosis and mild or no fibrosis in the two different groups. However, the univariate analysis assessing the association between the degree of fibrosis and the presence of steatohepatitis in both the two groups could not find any significant result. Conclusion: There was no significant association between steatohepatitis and the degree of fibrosis in patients with chronic HCV infection, either co-infection with other viruses or HCV infection alone.

Item Type:	Article (Journal)
Additional Information:	4050/4311
Subjects:	R Medicine > RB Pathology R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Dr Mohamed Hadzri Hasmoni
Date Deposited:	28 Oct 2011 14:57
Last Modified:	29 Dec 2011 07:35
URI:	http://irep.iium.edu.my/id/eprint/4311

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