Beyond anticoagulant: heparin as a potential anti-cancer agent

Lokwani, Ravi and Azmi, Nina Suhaity and Mohd Yusoff, Mashitah and Arief Ichwan, Solachuddin Jauhari (2014) Beyond anticoagulant: heparin as a potential anti-cancer agent. Journal of Biochemistry, Microbiology and Biotechnology, 2 (2). pp. 37-43. ISSN 2289-5779

PDF (Review Paper) - Published Version Restricted to Repository staff only Download (299kB) | Request a copy

Abstract

Heparin has been in the market since the last six decades due to its potential anticoagulant property. The mechanism of its anti-coagulation effect is well established. Along with its anticoagulant activity the other activity that is gathering a lot of importance now-a-days is its ability to arrest the progression of tumors specially some solid forms of tumors such as small cell lung carcinoma and pancreatic tumors. The chemically modified and light molecular weight fractions of heparin have been found to be more active in countering tumor progression. In this review we discuss a brief history of this versatile biomolecule with its clinical data and postulated mechanism of action as per recent studies. This review also highlighted the approach of heparin-conjugated nanoparticles to achieve targeted drug delivery with synergistic response in tumor cells.

Item Type:	Article (Journal)
Additional Information:	5731/40862
Uncontrolled Keywords:	heparin light molecular weight heparin metastasis angiogenesis
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry
Depositing User:	Dr. Solachuddin J.A. Ichwan
Date Deposited:	23 Jan 2015 16:14
Last Modified:	13 May 2015 17:18
URI:	http://irep.iium.edu.my/id/eprint/40862

Actions (login required)

View Item