Isolation and anti-proliferative activity of natural products from green seaweed

Zulhedi Ilyas, Fitriyanti and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2014) Isolation and anti-proliferative activity of natural products from green seaweed. In: 5th International Conference on Science & Technology: Applications in Industry & Education (ICSTIE 2014), 17-18 September 2014, Parkroyal Resort, Penang.

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Abstract

Seaweeds are marine organism that is chemically rich in source of different bioactive compounds of secondary metabolites. Selected green seaweed has been commonly consumed as human food due to their nutrient content. However, huge numbers of bioactive metabolites from green seaweed has been unexplored yet. The aims of this study are to isolate phytochemical from selected Malaysian seaweed and to investigate the antiproliferative activity of isolated compounds. Seaweed is extracted by soxhlet extractor with using organic solvents for 24 hours, and then the crude seaweed is fractionated by vacuum liquid chromatography and column chromatography. The isolated compounds of seaweed are characterized by HRMS, FTIR spectroscopy, 1D and 2D NMR spectroscopy. They also are studied for their ability to inhibit cell proliferation of breast cancer cell MCF-7 using MTT assay. Two isolated compounds that were identified as Coumarin derivative showed activity against MCF-7.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5641/40506
Uncontrolled Keywords:	seaweeds
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	26 Jan 2015 10:48
Last Modified:	26 Jan 2015 10:48
URI:	http://irep.iium.edu.my/id/eprint/40506

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