Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats

Al-Qaraghuli , Ahmed M.S. and Nafie, Emad M. and Al-Ani, Imad Matloub Dally and Faisal, Ghasak Ghazi (2012) Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats. In: 10th International Conference of Bioactive Compound and Functional Foods in Health and Disease , 13-15 March, 2012, University of California , Santa Barbara, (UCSB USA..

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Abstract

Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group) was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion.However, there was a faster and more complete healing process in the ranitidine treated group when compared to the XSYWW treated subjects. KEYWORDS: Ethanol, gastric ulcer, ranitidine, Xiang Sha Yang Wei Wan(XSYWW),traditional medicine.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5849/33866
Subjects:	Q Science > QM Human anatomy R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited:	06 Jan 2014 12:54
Last Modified:	18 Dec 2015 10:43
URI:	http://irep.iium.edu.my/id/eprint/33866

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