The effect of khat on sperm count and motility in parental mice and their offspring

AlBadri, Cinaria T. and Al-Ani, Imad Matloub Dally and Hiba , Hassan M. (2011) The effect of khat on sperm count and motility in parental mice and their offspring. In: Young Life Scientists Symposium Ireland 2011, 12th November 2011, University College Dublin.

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Abstract

Khat is considered a psychoactive drug and has many side effects on different parts of the body organs. In this study the effects of khat on sperm count and motility in parent mice and their offspring were investigated. Animals were divided into two groups, Group 1 (khat group)contained twelve male and twelve female mice, and they were given a daily dose of (50mg/kg) body weight khat extract by gastric gavage for four and eight weeks.Group 2 (control group)also contained twelve male and twelve female mice and received normal access of food and water. After four weeks of treatment, the males and females were allowed to mate and khat treatment continued for up to another four weeks. Twenty four male offspring from group 1 and group 2 were selected randomly and allowed to become mature. Male parent mice were killed at the 4th and 8th weeks of treatment, and their male offspring were killed when they reached maturity age (6-8weeks). Physiologicalexamination of the sperm solution showed that there was a significant increase in sperm count and motility after 4 and 8 weeks of khat treatment, and in their adult offspring.Furthermore, histological changes were found in testicular sections of the adult male mice. Keywords: Khat, offspring, sperm, testes

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5849/33864
Subjects:	Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited:	06 Jan 2014 13:19
Last Modified:	18 Dec 2015 10:47
URI:	http://irep.iium.edu.my/id/eprint/33864

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