Screening anti-cancer compounds from medicinal Malaysian plants

Ahmad Raus, Raha and Johari, Yusuf and Amid, Azura (2011) Screening anti-cancer compounds from medicinal Malaysian plants. In: Current Research and Development in Biotechnology Engineering at IIUM (volume II). IIUM Press, Kuala Lumpur, pp. 332-337. ISBN 978-967-418-151-2

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Abstract

In the fight against cancer. no,·el chemotherapeutic agems arc constanlly being sought to complement cxisting dTlJlls. In this study. 110-10 methanolic cxtracts prepared from seven tropical plants "'ith. eth.nomedical uses were tesled for th.eir c)'loto~ic ability in "itro against cancer cell lines. The plants studied were Carico papaya (papaya). Co/l'Ils bl"ml'i (ali·ati), Cosmos calldalll)· (uJam raja). "-'CIIS deltoidea (rna. OOlek), Pip"I" sm·WIIII/VSIIIll (kaduk), PIIle/'M indica (beluntas), and l'I"emlllu curdifloru (bcbuas). The c)'lolOxicity screening tesl, SRB (sulforhodamine B) was calTied out to detennine plants wilh potential amicancer properties. Results indicated that P. sonuentosllflI and P. cordijloru exlracis dcmonslr4[OO signifiean[ c)'101oxicily against MCn cell line where the IC", were 125 ilgfml and 113 ilgfmL. respectively, and a[ the same lime: showed less aclh-ilies against nonnal cells. Wilh re:spc:ct [0 Ihese results, P. sarmenflUum and P. r:ordif/oro eX!T1lCIS could be studied further fOJ [heir po[enlialto lTeal cance-r.

Item Type:	Book Chapter
Additional Information:	3911/20819
Uncontrolled Keywords:	anti-cancer, compounds, medicinal, plants
Subjects:	T Technology > TP Chemical technology T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Dr Raha Ahmad Raus
Date Deposited:	26 Nov 2012 15:30
Last Modified:	26 Nov 2012 15:30
URI:	http://irep.iium.edu.my/id/eprint/20819

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