Phytochemical screening and purification of Xoi from selected medicinal plant

Jamal, Parveen and Amid, Azura and Abdullah, Suhana (2011) Phytochemical screening and purification of Xoi from selected medicinal plant. In: Current Research and Development in Biotechnology Engineering at IIUM (volume II). IIUM Press, Kuala Lumpur, pp. 242-250. ISBN 978-967-418-151-2

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Abstract

Xanthine oxidase is an enzyme lhal catalyzes lhe oxidalion ofxanlhine 10 unc acid. which will be lhe cause of gout. Allopurinol is a medicine to cure gout nowadays. bUI il has many drawbacks. This slUdy a1H:mpls to cvaluale three local medicinal planls for their polentiallO be an alternative to allopurinol. The plan! species were Labisia pumila. !!fell/lla spica/a and LycopersiCOll esculenlu1ll. The results have re\'caled lhat methanolic cxtracl of Lrco['('rsicOll eSClIlemllm leaves has lhe highest XO inhibilory activity with 89.61 %. Therefore. it was selecled for the isolalion and purification of the bioaclive componenl lhal may be responsible for lhe said aClivity via two chromalographic procedures. namely, column chromatography aJld thin layer chromalography. One Spol was reco,·ered from Ihe separation via column chromalography ulilizing 8% MeOH - CHell as the elution system. Thc Rr value oblained via TlC for lhe Spol is 0.813.

Item Type:	Book Chapter
Additional Information:	2937/20803
Uncontrolled Keywords:	Lycopersicon esculentum. Labisia pumila, Mentha spicata, xanlhille oxidase inhibilor,purification
Subjects:	T Technology > TP Chemical technology T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Prof.Dr. Parveen Jamal
Date Deposited:	26 Nov 2012 15:58
Last Modified:	26 Nov 2012 15:59
URI:	http://irep.iium.edu.my/id/eprint/20803

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