Chondrocyte apoptosis: a cause or consequence of osteoarthritis?

Zamli, Zaitunnatakhin and Sharif, Mohammed (2011) Chondrocyte apoptosis: a cause or consequence of osteoarthritis? International Journal of Rheumatic Diseases, 14 (2). pp. 155-166. ISSN 1756-185X

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Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation and changes in the subchondral bone. Over the last two decades, there has been increasing evidence showing association between cartilage degradation and chondrocyte death, and different types of cell death in cartilage have been reported, including apoptosis and chondroptosis as well as necrosis, but which of these types of cell death predominate in OA is debatable. There are also some methodological difficulties in detecting the specific form of cell death in articular cartilage. Current ‘gold standard’ for detecting chondrocyte death is electron microscopy which suggests that the morphological changes of chondrocytes in OA cartilage are attributed to apoptosis and/or chondroptosis. However, the current literature appears to suggest that classic apoptosis plays an important role in OA; but whether chondrocyte apoptosis is a cause or a result of cartilage degeneration in OA is hotly contested. Studies of suitable animal models, especially longitudinal studies, are needed to address the cause-and-effect relationship.

Item Type:	Article (Journal)
Additional Information:	5401/2055
Uncontrolled Keywords:	articular cartilage degradation, chondrocyte apoptosis, osteoarthritis
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Zaitunnatakhin Zamli
Date Deposited:	03 Feb 2012 17:21
Last Modified:	20 Jun 2013 12:54
URI:	http://irep.iium.edu.my/id/eprint/2055

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