Use of prebiotics in oral delivery of bioactive compounds: a nanotechnology perspective

F., Heidarpour and M.R, Mohammadabadi and Sarker, Md. Zaidul Islam and B., Maherani and N., Saari and A.A, Hamid and F., Abas and M.Y.A, Manap and M.R, Mozafari (2011) Use of prebiotics in oral delivery of bioactive compounds: a nanotechnology perspective. Die Pharmazie -International Journal of Pharmaceutical Sciences, 66 (5). pp. 319-324. ISSN 0031-7144

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Abstract

The oral route is considered the most patient-convenient means of drug administration. In recent years there has been a tendency to employ smart carrier systems that enable controlled or timed release of a bioactive material, thereby providing a better dosing pattern and minimizing side effects. Nano-encapsulation systems (nanocarriers) offer important advantages over conventional drug delivery techniques. Nanocarriers can protect the drug from chemical/enzymatic degradation and enhance bioavailability. Prebiotics are ideal ingredients for the nano-encapsulation and oral drug delivery due to their natural ability to protect the encapsulated compound in the upper gasterointestinal (GI) tract. Here the potential of prebiotics for oral delivery of drugs and other bioactives is reviewed.

Item Type:	Article (Journal)
Additional Information:	6605/18655
Uncontrolled Keywords:	Drug Delivery Systems; Fermentation; Humans; Nanotechnology; Pharmaceutical Preparations; Polysaccharides; Prebiotics; Prodrugs; Tablets, Enteric-Coated
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action T Technology > TP Chemical technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Professor Md. Zaidul Islam Sarker
Date Deposited:	05 Dec 2013 16:28
Last Modified:	05 Dec 2013 16:29
URI:	http://irep.iium.edu.my/id/eprint/18655

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