Wound management strategies in a foot ulcer infected with methicillin-resistant staphylococcus aureus: a case report

Huda, Nurul Uswiyah and Jamaludin, Thandar Soe Sumaiyah and Hassan, Masmunaa and Qurrotunnada, Fatma and Nurumal, Mohd. Said (2026) Wound management strategies in a foot ulcer infected with methicillin-resistant staphylococcus aureus: a case report. International Journal of Care Scholars, 9 (2). pp. 136-143. ISSN 2600-898X

PDF - Published Version Restricted to Registered users only Download (2MB) | Request a copy

Abstract

Background: Diabetic foot ulcers (DFU) infected with Methicillin-Resistant Staphylococcus aureus (MRSA) represent a serious clinical challenge due to antimicrobial resistance, biofilm formation, and impaired wound healing in patients with diabetes mellitus. Management is further complicated in patients with multiple comorbidities, requiring an integrated and evidence-based approach to prevent progression to severe infection and amputation. This case report aims to evaluate the effectiveness of a comprehensive evidence-based wound care strategy in managing a MRSA-infected diabetic foot ulcer in a patient with multiple comorbidities. Case Presentation: A case of a 59-year-old female patient with type 2 diabetes mellitus (DM), hypertension, and stage III CKD was reported. The patient presented with a chronic ulcer on the left ankle associated with purulent discharge and fever, following a previously treated bimalleolar fracture. MRSA infection was confirmed through tissue culture. Management was guided by evidence-based wound care principles and included surgical debridement, culture-guided intravenous vancomycin therapy adjusted using therapeutic drug monitoring (TDM), and silver foam antimicrobial dressings. Within 14 days of intervention, the patient demonstrated marked clinical improvement. Systemically, fever resolved and inflammatory markers significantly decreased, with C-reactive protein (CRP) reduced from 19.45 mg/L to 0.89 mg/L. Locally, the wound showed progressive healing with a 70% reduction in wound size, decreased exudate, and formation of healthy granulation tissue covering most of the wound bed. Conclusion: A multimodal evidence-based approach combining surgical debridement, culture-guided antibiotic therapy, and silver-based antimicrobial dressings was effective in controlling MRSA infection and promoting wound healing in a complex diabetic patient

Item Type:	Article (Journal)
Uncontrolled Keywords:	Diabetic foot, Methicillin-resistant staphylococcal infections, Wound healing, Anti-infective agents, Evidence-based practice
Subjects:	R Medicine > RT Nursing
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Nursing > Department of Medical Surgical Nursing
Depositing User:	Dr. Thandar Soe @ Sumaiyah Jamaludin
Date Deposited:	23 Jun 2026 12:25
Last Modified:	23 Jun 2026 12:25
Queue Number:	2026-06-Q3725
URI:	http://irep.iium.edu.my/id/eprint/129417

Actions (login required)

View Item