Early postpartum alterations in blood pressure, vasoactive mediators, and inflammatory markers in L-NAME-induced hypertensive rats

Ganesan, Prianeesha and Mohd. Zainudin, Maizura and Zainal Abidin, Fadhilah (2024) Early postpartum alterations in blood pressure, vasoactive mediators, and inflammatory markers in L-NAME-induced hypertensive rats. In: 37th MSPP Annual Scientific Meeting 2024 & 9th Medical Research Symposium 2024, 8th October 2024, Kuantan, Pahang , Malaysia.

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Abstract

Introduction: Hypertensive disorders of pregnancy (HDP) affect 5% to 10% of pregnancies globally and increase the risk of cardiovascular disease (CVD) in women, despite postpartum blood pressure normalization. The mechanisms underlying this elevated risk remain unclear. This study investigates blood pressure variations, vasoactive mediator levels, and inflammatory markers in L-NAME-induced hypertensive rats during the early postpartum period. Materials and method: Normal control and L-NAME-induced hypertensive rats were monitored for blood pressure changes before pregnancy, at gestational day 19, and postpartum days 7 and 30. L-NAME, an inhibitor of nitric oxide (NO) synthesis, was utilized to induce hypertension. At postpartum day 30, rats were euthanized, and blood samples were analysed for various vasoactive mediators and inflammatory markers using ELISA. Results: The mean arterial pressure of the L-NAME group significantly increased and peaked at day 13 of pregnancy and reduced post-delivery. The mean concentrations of endothelin-1, interleukin-8, and C-reactive protein were higher in the L-NAME group compared to the control group, although these differences were not statistically significant. The mean concentrations of NO and plasminogen activator inhibitor-1 were lower in the L-NAME group compared to the control group, yet these differences were also not statistically significant. Conclusion: L-NAME- induced hypertensive rats demonstrate elevated blood pressure during pregnancy, with partial normalization postpartum. Despite the absence of statistically significant differences in vasoactive mediators and inflammatory markers between hypertensive and control groups, the observed trends underscore the need for further investigation. Elucidating the molecular pathways and mechanisms by which hypertensive disorders of pregnancy contribute to early- onset cardiovascular disease is crucial for advancing our understanding and improving clinical outcomes.

Item Type:	Proceeding Paper (Invited Papers)
Additional Information:	6122/124340
Uncontrolled Keywords:	Hypertensive disorders of pregnancy; cardiovascular disease; endothelin-1; nitric oxide; plasminogen activator inhibitor-1; C-reactive protein; interleukin-8
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Medicine
Depositing User:	Dr Maizura Mohd Zainudin
Date Deposited:	13 Nov 2025 17:46
Last Modified:	13 Nov 2025 17:47
URI:	http://irep.iium.edu.my/id/eprint/124340

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