Allhin, Audrey Ashleeynus and Wan Salleh, Wan Mohd Nuzul Hakimi and Salihu, Abubakar Siddiq and Arzmi, Mohd Hafiz and Ab Ghani, Nurunajah (2025) Deciphering the bioactive potential of four Malaysian Litsea species for antioxidant, antifungal, and antibiofilm activities. Agriculturae Conspectus Scientificus, 90 (2). pp. 151-157. ISSN 1331-7768 E-ISSN 1331-7776
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Abstract
This study evaluates the antioxidant, antifungal, and antibiofilm activities of methanolic leaf extracts from four Litsea species (L. glauca, L. fulva, L. rubicunda, and L. tomentosa), highlighting their potential as natural therapeutic agents. The antioxidant activity was assessed using the β-carotene/linoleic acid bleaching assay, DPPH radical scavenging assay, and total phenolic content (TPC) determination. Among the species, L. glauca exhibited the highest antioxidant activity, with an 85.2% inhibition of β-carotene bleaching, a DPPH IC50 value of 126.2 µg/mL, and the highest TPC of 130.1 mg GA·g-1, demonstrating a strong correlation between phenolic content and antioxidant efficacy. Antifungal activity was evaluated against Candida albicans, Candida lusitanae, and Candida auris, with L. tomentosa showing the strongest activity, achieving MIC and MFC values as low as 62.5 µg/mL against C. albicans. Antibiofilm activity was also notable, particularly for L. tomentosa and L. rubicunda, which significantly inhibited biofilm formation in C. lusitanae (70.0% and 65.5%, respectively) and C. auris (67.2% and 65.8%, respectively). These findings underscore the potential of Litsea species as sources of bioactive compounds for medicinal and industrial applications, warranting further research to isolate active constituents, elucidate mechanisms of action, and validate efficacy in vivo.
| Item Type: | Article (Journal) |
|---|---|
| Additional Information: | 7855/122447 |
| Uncontrolled Keywords: | Lauraceae, Litsea, antibiofilm, antifungal, antioxidant |
| Subjects: | Q Science > QK Botany Q Science > QR Microbiology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences |
| Depositing User: | AP Ts Dr Mohd Hafiz Arzmi |
| Date Deposited: | 07 Aug 2025 12:20 |
| Last Modified: | 07 Aug 2025 12:20 |
| URI: | http://irep.iium.edu.my/id/eprint/122447 |
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