Biological roles of selected microRNAs in glucose metabolism as a candidate biomarker for diabetes mellitus

Sassi, Assia and Bakhtiar, M. Taher and Khattak, Muhammad Muzaffar Ali Khan and Haron, Normah and Kaderi, Mohd Arifin and Rostam, Muhamad Ashraf and Mat Jusoh, Hanapi (2025) Biological roles of selected microRNAs in glucose metabolism as a candidate biomarker for diabetes mellitus. Molecular Nutrition & Food Research, 69 (12). pp. 1-9. ISSN 1613-4125 E-ISSN 1613-4133

	PDF (Review) - Published Version Restricted to Repository staff only Download (414kB) | Request a copy
Preview	PDF - Supplemental Material Download (227kB) | Preview
Preview	PDF - Supplemental Material Download (251kB) | Preview

Abstract

Type 2 diabetes mellitus (T2DM) is a medical disorder characterized by high blood sugar levels resulting from a lack of insulin caused by impaired activity of β-cells and/or the inability of insulin to efficiently transport glucose from the bloodstream into cells, a condition referred to as insulin resistance. This occurs not only in insulin-sensitive tissues such as muscles, adipose tissue, and the liver, but also in the gastrointestinal tract, which may be caused by a defect in the insulin signaling pathway. MicroRNAs (miRNAs) are RNA molecules that do not code for proteins and play a role in multiple pathways. Several studies have suggested that specific miRNAs could potentially be used as biomarkers for diagnosing diabetes. These miRNAs regulate the formation of pancreatic islets, the differentiation of β-cells, the secretion of insulin, and the control of glucose metabolism. miRNA-mediated pathways are associated with human genetic illnesses resulting from mutations in the maturation process of miRNAs. The changes in miRNAs impact their ability to bind to mRNA targets, hence modifying gene expression. This review provides a concise overview of the latest studies investigating the correlation between miRNA expression and the regulation of glucose levels in cases of β-cell malfunction and insulin resistance.

Item Type:	Article (Review)
Additional Information:	5145/122362
Uncontrolled Keywords:	diabetes; gene expression; insulin; microRNA; β-cells
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM216 Diet Therapy. Clinical Nutrition T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology
Depositing User:	Prof Dr Muhammad Muzaffar Ali Khan Khattak
Date Deposited:	07 Aug 2025 10:55
Last Modified:	07 Aug 2025 11:09
URI:	http://irep.iium.edu.my/id/eprint/122362

Actions (login required)

View Item