Chemical composition and biological activities of essential oil of the Malaysian endemic Syzygium variolosum (King) Chantar . & J.Parn

Mohd Rahim, Faezatul Alwani and Wan Salleh, Wan Mohd Nuzul Hakimi and Ab Ghani, Nurunajah and Salihu, Abubakar Siddiq and Arzmi, Mohd Hafiz (2025) Chemical composition and biological activities of essential oil of the Malaysian endemic Syzygium variolosum (King) Chantar . & J.Parn. Natural Product Research, 39 (14). pp. 4179-4181. ISSN 1478-6419 E-ISSN 1478-6427

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Abstract

This study was designed to investigate the chemical composition of the essential oil of Syzygium variolosum (King) Chantar. & J.Parn. and their cytotoxicity, acetylcholinesterase, antityrosinase, and anti-inflammatory activities. In total, 32 chemical components were identified in the essential oil, which made up 98.9%. The essential oil is mainly composed of β-elemene (20.2%), bicyclogermacrene (13.5%), viridiflorol (11.1%), globulol (8.6%), and selin-11-en-4α-ol (5.3%). Acetylcholinesterase, antityrosinase, and anti-inflammatory activities were evaluated with the Ellman method, mushroom tyrosinase, and lipoxygenase enzymes, respectively, while cytotoxicity was assessed using an MTT assay. The results showed that essential oil gave significant percentage inhibition (I%: acetylcholin-esterase 35.2%, antityrosinase 42.5%, lipoxygenase 48.6%). Furthermore, the essential oil exhibited cytotoxicity against three cancer cell lines, HepG2, MCF7, and A549, with IC50 values ranging from 90.2 to 95.2 μg/mL. The current study highlights the potential of the use of essential oils as an alternative to the development of pharmaceutical antichemopreventives or cosmetics.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Syzygium variolosum; essential oil; bicyclogermacrene; cholinesterase; tyrosinase; lipoxygenase
Subjects:	Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Dentistry
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	21 Jul 2025 11:33
Last Modified:	21 Jul 2025 11:33
URI:	http://irep.iium.edu.my/id/eprint/122126

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