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Recent advances in oral potentially malignant disorders: a therapeutic perspective from an oral and maxillofacial clinician and pathologist – a systematic review

Shunmugavelu, Karthik and Suganya, S. and Jeevanandam, L. and Dowlath Saheb, Samiullah (2025) Recent advances in oral potentially malignant disorders: a therapeutic perspective from an oral and maxillofacial clinician and pathologist – a systematic review. Journal of Neonatal Surgery, 14 (8). pp. 560-566. E-ISSN 2226-0439

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Abstract

Oral potentially malignant disorders (OPMDs) are recognized precursors to oral squamous cell carcinoma (OSCC) and pose a major diagnostic and therapeutic challenge. This systematic review critically synthesizes recent advances in the classification, diagnosis, molecular pathology, viral associations, and therapeutic management of OPMDs. Systematic literature review according to PRISMA guidelines selected 8 major studies between 2021 and 2025. Developing evidence from literature points toward the role of advanced classification systems, artificial intelligence-guided diagnostics, metabolomic profiling, microenvironmental modulation, and viral oncogenesis in enhancing early diagnosis and risk stratification. Challenges persist with standardization of diagnostic modalities, cross-population validation of biomarkers, and making new technologies universally accessible globally. An integrated multidisciplinary strategy that includes technological advancements and molecular understanding is needed to maximize preventive measures and minimize the global burden of oral cancer.

Item Type: Article (Review)
Additional Information: This is a collaborative between IIUM and Pondicherry University, Affiliated to Pondicherry University, Puducherry, India.
Uncontrolled Keywords: : Oral potentially malignant disorders, oral squamous cell carcinoma, viral infections, artificial intelligence, microenvironment, metabolomics, early detection.
Subjects: R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User: DR SAMIULLAH DOWLATH SAHEB
Date Deposited: 08 Jul 2025 16:09
Last Modified: 08 Jul 2025 16:09
URI: http://irep.iium.edu.my/id/eprint/121979

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