Unveiling the chemical composition and bioactivity potential of the essential oil of alpinia glabra ridl. (Zingiberaceae)

Robert, Anjelica and Wan Salleh, Wan Mohd Nuzul Hakimi and Salihu, Abubakar Siddiq and Ab Ghani, Nurunajah and Arzmi, Mohd Hafiz (2026) Unveiling the chemical composition and bioactivity potential of the essential oil of alpinia glabra ridl. (Zingiberaceae). Natural Product Research, 40 (8). pp. 2274-2281. ISSN 1478-6419 E-ISSN 1478-6427

	PDF - Published Version Restricted to Registered users only Download (1MB) | Request a copy
	PDF (Scopus) - Supplemental Material Restricted to Registered users only Download (206kB) | Request a copy
	PDF (WOS) - Supplemental Material Restricted to Registered users only Download (392kB) | Request a copy

Abstract

This study investigated the chemical composition, antifungal, antibiofilm and anticholinesterase inhibitory activities of the essential oil from Alpinia glabra Ridl. (Zingiberaceae) from Malaysia. The essential oil was extracted by hydrodistillation and analysed using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS), revealing 35 chemical components comprising 98.3% of the total oil. The major components identified were β-cadinene (28.5%), benzaldehyde (8.0%), δ-cadinene (6.0%), (E)-nerolidol (5.4%), α-cadinol (4.8%), and viridiflorol (4.0%). Antifungal tests against Candida albicans (ATCC MYA-4901) and Streptococcus mutans (Ingbritt) showed MIC values of 250µg/mL. The essential oil increased the biofilm of Candida albicans by 42.14%, however, decreased the biofilm of Streptococcus mutans by 64.41% when treated with 500µg/mL. The essential oil exhibited moderate anticholinesterase activity with 48.5% and 57.2% inhibition of acetylcholinesterase and butyrylcholinesterase, respectively, at 500µg/mL. These findings highlight the potential applications of A. glabra essential oil in antifungal, antibiofilm and anticholinesterase therapies..

Item Type:	Article (Journal)
Uncontrolled Keywords:	Essential oil; Alpinia glabra Ridl.; β-cadinene; antifungal; antibiofilm; anticholinesterase
Subjects:	Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	Prof Ts Dr Mohd Hafiz Arzmi
Date Deposited:	13 Jul 2026 15:55
Last Update:	13 Jul 2026 15:55
Queue Number:	2026-07-Q4112
URI:	http://irep.iium.edu.my/id/eprint/120935

Actions (login required)

View Item