Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis

Nawawi, Muhammad Hariadi and Arzmi, Mohd Hafiz and Azmi, Afiza and Azizudin, Maryam Al-Batul (2025) Evaluating the efficacy of probiotics in the prevention and treatment of atopic dermatitis in adult patients - a systematic review and meta-analysis. Malaysian Journal of Medicine and Health Sciences, 21 (2). pp. 216-226. ISSN 1675-8544 E-ISSN 2636-9346

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Abstract

Introduction: The purpose of this systematic review and meta-analysis was to determine the potential benefits of probiotics in the treatment of atopic dermatitis (AD) in adults. Materials and methods: A meta-analysis was per-formed on randomized controlled trials investigating the use of probiotics, either applied to the skin or taken orally, to decrease AD severity in adult patients. A comprehensive search gathered all available trials from January 1st, 2012 until November 1st, 2023. The analysis was carried out using Review Manager 5 software. Results: In a study involving 10 prevention studies with 457 adult participants, probiotics significantly reduced AD severity compared to the control group, as indicated by SCORAD scores (MD: -7.92; 95% CI -11.69 to -4.15; p < 0.0001). Both short-term and long-term treatments showed significant reductions in SCORAD scores. Single-strain and mixed-strain probiotics were both effective. Probiotics improved SCORAD scores for both young and middle-aged adults. Internal (oral) and external (topical) interventions both significantly reduced AD severity. Probiotics had a significant impact on SCORAD scores in both Europe and Asia. The effectiveness of probiotics was consistent regardless of treatment duration, type of probiotics used (single-strain probiotics vs. mixed-strain probiotics), participant age, intervention type, or geographical area. Conclusion: Probiotics significantly alleviate allergic symptoms in adults with AD, demonstrating consistent effectiveness across various factors including treatment duration, type of probiotics, participant age, intervention type, and geographical area.

Item Type:	Article (Review)
Uncontrolled Keywords:	Probiotics, Eczema, Atopic dermatitis, Adult, Treatment, Meta-analysis
Subjects:	Q Science > QR Microbiology R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	25 Apr 2025 11:05
Last Modified:	25 Apr 2025 11:05
URI:	http://irep.iium.edu.my/id/eprint/120704

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