A review on the development of microcarriers for cell culture applications

Swana, Sia Yiik and Hairunnaja, Muhammad Auni and Samsudin, Nurhusna and ., Syed Mahmood and Abd Aziz, Mohd Aizudin and Arifin, Mohd Azmir (2024) A review on the development of microcarriers for cell culture applications. Pertanika Journal Science and Technology, 32 (5). pp. 1939-1962. ISSN 0128-7680 E-ISSN 2231-8526

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Abstract

Microcarrier-based cell culture systems have gained significant attention and popularity in tissue engineering and regenerative medicine. In this culture system, tissue cells are grown as a monolayer on the surface of small solid particles called microcarriers (100 to 300 μm), kept suspended in the culture medium by stirring. This technology has paved the way for creating engineered tissues, one of the cutting-edge topics in tissue engineering and regenerative medicine. Microcarrier-based approaches have been proposed for three-dimensional (3D) cell culture in which cellular morphology and functions are maintained in vivo. This paper provides an overview of the optimal characteristics such as microcarriers’ size, shape, density and porosity. Various methods of preparation of microcarriers and surface modification techniques have been elaborated. Recent advances and applications of microcarriers in biotechnology fields, like the production of viral vaccines and recombinant proteins, culture and expansion of stem cells (SC), are described.

Item Type:	Article (Journal)
Additional Information:	8648/119015
Uncontrolled Keywords:	Biomolecule immobilization, microcarrier, polymer, preparation, surface modification
Subjects:	BPC Science and Technology in Islam > BPC175 Islam and engineering. Sustainable engineering. Sustainable building T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	Dr Nurhusna Samsudin
Date Deposited:	31 Jan 2025 17:08
Last Modified:	31 Jan 2025 17:10
URI:	http://irep.iium.edu.my/id/eprint/119015

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