Hasim, Husna Syaza and Zaki, Hafizatul Solehah and Mussadik, Umul Khairil Fatimah and Chng, Kay Ly
(2023)
Lung chronicles: decoding granulomatous disease; role of molecular study.
Malaysian Journal of Pathology, 45 (3).
p. 521.
ISSN 0126-8635
E-ISSN 0126-8635
Abstract
Introduction: Granuloma alone is a nonspecific histopathological finding, rather it comprises a group of disorders which have
a wide spectrum of pathologies. The integration of histological analysis and molecular study is crucial in concluding a case in
the field of forensic pathology. Case report: A 43-year-old Malay gentleman was found unconscious at his home. Reportedly,
he has no known medical illness but was an intravenous drug user and had multiple histories of prison detention, though
he was not under custody at that moment. He had a short history of fever and shortness of breath. External examination
revealed a cachexic, medium body-built with no marks of injury. However, upon opening the chest, there was generalized
adhesion of the pleura with cavitations of bilateral lungs and copious amounts of pus-like secretions. Histological analysis
of the lung sections showed presence of few multinucleated giant cells. Discussion: Presence of lung cavitations grossly,
together with giant cells with or without granuloma histologically, were frequently associated with mycobacteria infection.
This has not always been the case, particularly in the case reported above as the sample sent for molecular study did not
detect mycobacteria. What is highlighted under the microscope will somehow need to be further investigated with molecular
study, either to nullify or confirm the preliminary findings.
| Item Type: |
Article
(Abstract)
|
| Uncontrolled Keywords: |
mycobacterium tuberculosis, granuloma, forensic autopsy, molecular |
| Subjects: |
R Medicine > RB Pathology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): |
UNSPECIFIED |
| Depositing User: |
Dr Kay Ly Chng
|
| Date Deposited: |
09 Oct 2024 10:58 |
| Last Modified: |
09 Oct 2024 12:11 |
| URI: |
http://irep.iium.edu.my/id/eprint/114915 |
Actions (login required)
 |
View Item |
Download Statistics
Download Statistics