Immunogenicity of monoclonal antibody: causes, consequences, and control strategies

Asmani, Ahmad Zafran Amin and Zainuddin, Ahmad Faris Fahmi and Ahmad Azmi Murad, Nadhirah and Mohd Darwis, Nur Hidayati and Suhaimi, Nur Suhaida and Zaini, Erizal and Bakhtiar, M. Taher and Darnis, Deny Susanti and Khotib, Junaidi (2024) Immunogenicity of monoclonal antibody: causes, consequences, and control strategies. Pathology-Research and Practice, 263. pp. 1-11. ISSN 0344-0338 E-ISSN 1618-0631

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Abstract

Antibody-based treatment was first used in 1891 for the treatment of diphtheria. Since then, monoclonal antibodies (mAbs) have been developed to treat many diseases such as cancer and act as vaccines. However, murine-derived therapeutic mAbs were found to be highly immunogenic, and caused anti-drug antibodies (ADAs) reaction, reducing their efficacy and causing severe infusion reactions. Fully human, humanised, and chimeric antibodies were then introduced for better therapeutic efficacy. With the introduction of immune response associated with mAbs immunogenicity. This review explores the immunogenicity of mAbs, its mechanism, contributing factors, and its impact on therapeutic efficacy. It also discusses immunogenicity assessment for preclinical studies and strategies for minimising immunogenicity for effective therapeutic treatment in various diseases. Finally, predicting immunogenicity in drug development is essential for selecting top drug candidates. A lot of methods can be implemented by the researchers and developers to reduce the development of ADAs while simultaneously minimising the immunogenicity reaction of mAbs.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Immunogenicity Immune response Anti-drug antibody Immunogenicity prediction Hypersensitivity reaction
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science > Department of Chemistry Kulliyyah of Pharmacy Kulliyyah of Science
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	02 Oct 2024 10:59
Last Modified:	02 Oct 2024 10:59
URI:	http://irep.iium.edu.my/id/eprint/114788

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