Sukmasari, Susi and Abdul Rahman, Mohammad Nasrin and Doolaanea, Abd Almonem and Arzmi, Mohd Hafiz and Mezan, Nur Zakirah and Mohammad Muzafar Shah, Azyyati and Maghzan, Putri Izz Khayrin (2024) Elucidation profile analysis Syzygium cumini extract to be developed as oral anti-mucositis gel. Journal of Medicinal and Pharmaceutical Chemistry Research, 6 (12). pp. 1888-1904. ISSN 2981-0221 E-ISSN 2981-0213
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Abstract
Syzygium cumini is a traditional medicinal plant that has been used to treat various ailments. This study is conducted to characterise the extract contents, rheological, release, and texture profile of Syzygium cumini gel to be developed as anti- mucositis gel for dental applications. To determine the phytochemical content, Supercritical Fluid Extraction, and Soxhlet extractions were conducted. Whereas rheological characterisation, release, and texture profiles of five different gels were formulated using SC leaves extracted using sequential cold percolation (toluene, petroleum ether, acetyl acetate, acetone, and water extract). The rheological, release and texture profiles of the gels were then measured using rheometer, incubator shaker, and texture analyser, respectively. It was found that SC leaves extracted using Soxhlet contains the highest total phenolic and catechin content, while epicatechin content was highest in the extract of Supercritical Fluid Extraction with carbon dioxide as solvent at 150 bar. Regarding the gels, water extract gel had the best rheological profile. Although water extract had low permeability coefficient based on the release profile test, there was statistically significance difference in term of permeation rate flux from other gels (P<0.05). Phytochemical content and other related data were successfully documented to help in elucidating the best dental gel to be developed as antimucositis gel.
| Item Type: | Article (Journal) |
|---|---|
| Uncontrolled Keywords: | Supercritical fluid extraction; antimucositis; dental; gel; Rheology; Soxhlet; catechin; epicatechin |
| Subjects: | Q Science > QR Microbiology R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Dentistry > Department of Paediatric Dentistry and Dental Public Health Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology |
| Depositing User: | Dr. Susi Sukmasari |
| Date Deposited: | 13 Aug 2024 11:38 |
| Last Modified: | 13 Aug 2024 11:39 |
| URI: | http://irep.iium.edu.my/id/eprint/113856 |
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