Single nucleotide polymorphism of leptin and leptin receptor genes in oral cancer - a systematic review

Hasanbasri, Siti Hana Ilyana and Amir Sabri, Nur Armidha Nadihah and Mokhtar@Makhtar, Khairani Idah and Mustafa Al-Ahmad, Basma Ezzat and Mohd Ibrahim, Mohamad Shafiq and Subramaniam, Pram Kumar (2024) Single nucleotide polymorphism of leptin and leptin receptor genes in oral cancer - a systematic review. IIUM Journal of Orofacial and Health Sciences, 5 (2). pp. 164-172. E-ISSN 2735-0584

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Abstract

Oral cancer is one of the serious health problems diagnosed worldwide including Malaysia. While much research has been done on the gene polymorphism of leptin and leptin receptor genes in other cancers, few researchers have considered oral cancer. Hence, this study aims to provide an insight into the association of a single nucleotide polymorphism of leptin and leptin receptor genes with oral cancer, as well as its contribution in increasing the risk for oral cancer development. Literature searches were conducted in six databases including Scopus, ScienceDirect, Web of Science, PubMed, Google Scholar, and Dimensions; focusing on articles published between 2000 to 2020. All relevant articles were screened accordingly using search terms “leptin”, “leptin receptor”, “single nucleotide polymorphism” and “oral cancer”. A total of 2699 articles were retrieved. After following the inclusion and exclusion criteria, only four articles were included in this systematic review highlighting the three commonly studied polymorphic variant of leptin and leptin receptor which are LEP -2548 G/A, LEPR Gln223Arg, and LEPR K109R. Single nucleotide polymorphism of leptin and leptin receptor genes specifically LEPR Gln223Arg and LEP -2548 G/A may increase the risk of development of oral cancer. There were limited sources available to support the findings. Further research and investigations are needed to explore the mechanism of leptin and leptin receptor genes in the development of oral cancer.

Item Type:	Article (Review)
Uncontrolled Keywords:	leptin, leptin receptor, oral cancer, oral squamous cell carcinoma, single nucleotide polymorphism
Subjects:	R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Dentistry
Depositing User:	Assoc Prof Khairani Idah Mokhtar
Date Deposited:	05 Aug 2024 12:37
Last Modified:	05 Aug 2024 12:37
URI:	http://irep.iium.edu.my/id/eprint/113665

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