Virulence factors of the Zoonotic Pathogen Vibrio alginolyticus: a review and bibliometric analysis

Sheikh Mohamed, Hassan Ibrahim and Alhamadin, Nawal Ismail Issa and Liew, Hon Jung and Fadhlina, Anis and Abd Wahid, Mohd Effendy and Musa, Najiah and Khan Chowdhury, Ahmed Jalal (2024) Virulence factors of the Zoonotic Pathogen Vibrio alginolyticus: a review and bibliometric analysis. Applied Biochemistry and Microbiology, 60. pp. 514-531. E-ISSN 1608-3024

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Abstract

Vibrio alginolyticus is an opportunistic Gram-negative marine bacterium that infects animals and humans. Its virulence is associated with numerous factors such as cytotoxicity, adhesion and biofilm formation. This review aimed to quantitatively assess the V. alginolyticus’s virulence factors to identify the main mechanisms of infection. A systematic literature search was conducted using SCOPUS databases up to 31 December 2022. The bibliometric analysis was performed using VOSviewer software. The results showed that toxins are the most common virulence factor making up more than 50% of virulence-related keywords. This was followed by adhesion/biofilm (12%), antibiotic resistance (9%) and quorum sensing (9%). In terms of cytotoxicity, hemolysins were the most common toxins, while in terms of secretion system, type III secretion system (T3SS) was the most common. Extracellular polysaccharide production was the main parameter related to adhesion and biofilm. In terms of antibiotic resistance, extended-spectrum β-lactamases (ESBLs) genes were the most common, and for quorum sensing, N-acyl homoserine lactone (AHL) was the most common. Vibrio pathogenicity island was also identified as a mechanism for accumulating virulence factors. Toxin-coregulated pilus (Tcp) was identified as the main motility-related virulence factor. This review reports that quorum sensing and kinase inhibitors are promising drug targets. Identifying these mechanisms can help in establishing ideal drug targets and management approaches for V. alginolyticus-related infections.

Item Type:	Article (Review)
Uncontrolled Keywords:	Vibrio alginolyticus, zoonotic bacteria, pathogenicity, cytotoxicity, VOSviewer
Subjects:	Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	Dr. Anis Fadhlina
Date Deposited:	17 May 2024 15:25
Last Modified:	09 Sep 2024 08:24
URI:	http://irep.iium.edu.my/id/eprint/111735

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