Chemical composition, antifungal, antibiofilm, and molecular docking studies of syzygium dyerianum essential oil

Mohd Rahim, Faezatul Alwani and Wan Salleh, Wan Mohd Nuzul Hakimi and Arzmi, Mohd Hafiz and Salihu, Abubakar Siddiq (2024) Chemical composition, antifungal, antibiofilm, and molecular docking studies of syzygium dyerianum essential oil. Zeitschrift für Naturforschung C. pp. 1-8. ISSN 0939-5075 E-ISSN 1865-7125

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Abstract

The current study describes the chemical compo- sition, antifungal, antibiofilm, antibacterial and molecular docking studies of Syzygium dyerianum growing in Malaysia. The essential oil was obtained through hydrodistillation and characterized using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The antifungal and antibacterial activities were developed using the broth microdilution assay, whereas the effect on the microbial biofilms was determined using a semi-quantitative static bio- film assay. A total of 31 components were identified, which represent 99.5 % of the essential oil. The results revealed that the essential oil consisted mainly of β-pinene (15.6%), α-terpineol (13.3%), α-pinene (11.1%), caryophyllene oxide (8.8%), limonene (8.1%), borneol (6.0%) and viridiflorol (5.1 %). The results of the microdilution method showed that essential oil exhibited activity against Candida albicans and Streptococcus mutans with minimal inhibitory concentration values of 125 and 250μg/mL, respectively. Furthermore, essential oil decreased the biofilm of C. albicans and S. mutans by 20.11 ± 0.27% and 32.10 ± 4.81% when treated with 250μg/mL. The best docking energy was observed with viridiflorol (−29.7 kJ/mol). This study highlights that essential oil can potentially be a natural antifungal, antibacterial, and antibiofilm agent that could be applied in the pharmaceutical and food industries.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Myrtaceae; essential oil; Syzygium dyerianum; β-pinene; antifungal; antibiofilm
Subjects:	Q Science > QK Botany Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	13 Mar 2024 08:56
Last Modified:	02 Aug 2024 16:29
URI:	http://irep.iium.edu.my/id/eprint/111333

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