Virulence factors and mechanisms of Aeromonas hydrophila infection in catfish Siluriformes: a review and bibliometric analysis

Sheikh Mohamed, Hassan Ibrahim and Nordin, Baiduri and Paharuddin, Nurhalimah and Liew, Hon Jung and Awang, Anis Fadhlina Izyani and Abdulrazzak, Laith A. and K.C.A., Jalal and Musa, Najiah (2023) Virulence factors and mechanisms of Aeromonas hydrophila infection in catfish Siluriformes: a review and bibliometric analysis. Desalination and Water Treatment, 315. pp. 538-547. ISSN 1944-3994 E-ISSN 1944-3986

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Abstract

Aeromonas hydrophila, a gram-negative bacterium belonging to the Aeromonadaceae family, has significantly impacted global catfish production within the Siluriformes family, resulting in economic losses. Despite being recognized as part of the normal flora found in water systems and fish organs, the pathogenicity of A. hydrophila is often activated by the expression of virulence genes encoding toxins. To systematically gather reliable scientific studies on the virulence of A. hydrophila in catfish Siluriformes, the PRISMA method was employed, utilizing the Scopus database. Following the application of inclusion and exclusion criteria, a total of 66 documents were scrutinized, and a bibliometric analysis was conducted using VOSviewer. Based on the keyword analysis, aerolysin toxin emerged as the most prevalent virulence factor, appearing in 64% (n = 42) of the papers, followed by hemolysin, enterotoxin, and biofilm. The analysis also revealed that the primary organs associated with infection were the kidney and liver, recognized as immune secretion organs, followed by the gills, intestine, skin, and mucus, identified as entry points. The major clinical signs of A. hydrophila infection included hemorrhage, lesion, ulceration, and septicemia. This study elucidates the scientific consensus on the infection mechanisms of A. hydrophila, covering entry points, adherence, and invasion. The ranked entry points and virulence factors identified herein offer valuable insights for designing novel treatments or preventive measures in catfish farming.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Catfish; Siluriformes; Aeromonas hydrophila; Virulence; Aerolysin; VOSviewer
Subjects:	Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	Dr. Anis Fadhlina
Date Deposited:	07 Feb 2024 12:44
Last Modified:	12 Jul 2024 15:24
URI:	http://irep.iium.edu.my/id/eprint/110765

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