Chemical composition of essential oil from lindera subumbelliflora kosterm and its effect on the susceptibility and biofilm activities of candida albicans and streptococcus mutans

Mohd Zain, Nur Nabilah and Wan salleh, Wan Mohd Nuzul hakimi and Arzmi, Mohd Hafiz and Salihua, Abubakar Siddiq and Ab Ghani, Nurunajah (2023) Chemical composition of essential oil from lindera subumbelliflora kosterm and its effect on the susceptibility and biofilm activities of candida albicans and streptococcus mutans. Natural Product Research. pp. 1-6. ISSN 1478-6419 E-ISSN 1478-6427 (In Press)

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Abstract

the chemical composition of the essential oil of Lindera subumbel- liflora (Lauraceae) was investigated for the first time. the essential oil was obtained by hydrodistillation and fully characterised by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-mS). the antifungal activity of L. subumbelliflora essential oil was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. a total of 28 components (99.6%) were successfully identified, which were characterised by β-eudesmol (14.6%), cis-α-bergamotene (11.0%), α-copaene (8.5%), dodecen-1-ol (8.5%), and (E)-nerolidol (8.3%). the essential oil exhibited activity against Candida albicans and Streptococcus mutans with miC values of 250 and 500 μg/mL, respectively. the essential oil increased the biofilm of Candida albi- cans by 38.25%, however, decreased the biofilm of Streptococcus mutans by 47.89% when treated with 500μg/mL. thus, the essen- tial oil has a promising application in dentistry via inhibition of the growth of Candida albicans and Streptococcus mutans. However, the antibiofilm activity of the essential oil is only applicable for cario- genic Streptococcus mutans.

Item Type:	Article (Review)
Uncontrolled Keywords:	Essential oil; lindera subumbelliflora; β-eudesmol; antifungal; antibiofilm; candida albicans
Subjects:	Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	20 Nov 2023 12:16
Last Modified:	20 Nov 2023 12:16
URI:	http://irep.iium.edu.my/id/eprint/108241

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